Article
Neurosciences
Ping Cai, Wei-Kun Su, Jin-Sheng Zhang, Pei-Chang Liu, Feng Liu, Ren-Fu Liu, Zhang-Shu Li, Zhong-Hua Zhu, Wen-Hao Xiao, Yong-Huai Hu, Hong-Da Cai, Xiao-Dan Wu, Liang-Cheng Zhang, Changxi Yu, Li Chen
Summary: Recent evidence suggests a potential overlap between general anesthesia and sleep-wake behavior. In this study, using fiber photometry, it was observed that the activity of GABAergic neurons in the basal forebrain (BF) was inhibited during isoflurane anesthesia, but gradually restored during emergence. Activation of these neurons reduced sensitivity to isoflurane, delayed induction, and accelerated emergence from anesthesia. Photostimulation of GABAergic terminals in the thalamic reticular nucleus (TRN) also promoted cortical activation and behavioral emergence from anesthesia.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Multidisciplinary Sciences
Momoka Kuroda, Yoshiko Suetsugu, Sachiko Iwata, Masahiro Kinoshita, Fumie Fujita, Yoko Sato, Shinji Saitoh, Osuke Iwata, Seiichi Morokuma
Summary: This study aimed to analyze the influence of mothers' nighttime responses on the sleep-wake rhythm of their 1-month-old infants. Findings showed that immediately picking up 1-month-old infants may result in longer daytime sleep compared to nighttime sleep, possibly due to the stimulating effects of picking up the infant on sleep-wake rhythm formation.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Didier De Saint Jan
Summary: This study investigated the role of basal forebrain (BF) inputs in modulating activity of different subtypes of periglomerular (PG) interneurons in the olfactory bulb (OB). The results showed that GABAergic BF inputs effectively inhibited PG cell firing, while cholinergic inputs excited a previously overlooked PG cell subtype. These findings highlight the importance of external inputs in synaptic inhibition in the OB.
Article
Neurosciences
E. K. Erickson, A. J. DaCosta, S. C. Mason, Y. A. Blednov, R. D. Mayfield, R. A. Harris
Summary: Astrocytes play a crucial role in the behavioral effects of ethanol through GPCR-mediated calcium signaling. Activation of G(q)-DREADD in astrocytes increases ethanol intake, while reducing calcium signaling decreases sensitivity to ethanol. Astrocyte calcium signaling also alters the stimulatory and sedative-hypnotic effects of ethanol.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Miguel A. Labrador-Espinosa, Jesus Silva-Rodriguez, Maria Isabel Reina-Castillo, Pablo Mir, Michel J. Grothe
Summary: This study aimed to investigate whether the association between degeneration of the cortically-projecting cholinergic basal forebrain (cBF) and cognitive decline in Parkinson's disease (PD) is mediated by parallel atrophy of cortical areas, and whether this association depends on the presence of comorbid Alzheimer's disease (AD). The results showed a significant correlation between cBF degeneration, cortical thinning, and cognitive decline, independent of amyloid-β status.
MOVEMENT DISORDERS
(2023)
Article
Multidisciplinary Sciences
Guofen Ma, Yanmei Liu, Lizhao Wang, Zhongyi Xiao, Kun Song, Yanjie Wang, Wanling Peng, Xiaotong Liu, Ziyue Wang, Sen Jin, Zi Tao, Chengyu T. Li, Tianle Xu, Fuqiang Xu, Min Xu, Siyu Zhang
Summary: Through rabies-virus tracing and optogenetics-assisted recording, this study revealed the selectivity of different neurons to long-range connections in various brain regions along the hierarchy of visual processing. The results showed that bottom-up and top-down inputs prefer PV+ and VIP+ neurons respectively, providing important clues for hierarchical information flow in the brain.
Article
Neurosciences
Marcel Daamen, Lukas Scheef, Shumei Li, Michel J. Grothe, Florian C. Gaertner, Ralph Buchert, Katharina Buerger, Laura Dobisch, Alexander Drzezga, Markus Essler, Michael Ewers, Klaus Fliessbach, Ana Lucia Herrera Melendez, Stefan Hetzer, Daniel Janowitz, Ingo Kilimann, Bernd Joachim Krause, Catharina Lange, Christoph Laske, Matthias H. Munk, Oliver Peters, Josef Priller, Alfredo Ramirez, Matthias Reimold, Axel Rominger, Ayda Rostamzadeh, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan J. Teipel, Michael Wagner, Emrah Duezel, Frank Jessen, Henning Boecker
Summary: This study found that amyloid-positive individuals with subjective cognitive decline (SCD) already show early alterations of cholinergic basal forebrain (BF) integrity, which is negatively correlated with cortical amyloid burden. However, further research is needed to determine whether these changes emerge at grey zone levels of amyloid accumulation.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Tiago Bortolini, Bruno Melo, Rodrigo Basilio, Ronald Fischer, Roland Zahn, Ricardo de Oliveira-Souza, Brian Knutson, Jorge Moll
Summary: This study explores the intrinsic motivation of humans to bond with others and the role of reward circuitry in the anticipation and response to affiliative rewards. The findings suggest a general appetitive response in the Nucleus Accumbens to different types of rewards, while a more specific response is seen in the septo-hypothalamic region to affiliative rewards. The new task presented in this work allows for distinguishing between neural responses to affiliative and non-affiliative rewards.
Article
Neurosciences
Srestha Dasgupta, Laura E. Montroull, Mansi A. Pandya, Juan P. Zanin, Wei Wang, Zhuhao Wu, Wilma J. Friedman
Summary: Traumatic brain injury (TBI) leads to the loss of basal forebrain cholinergic neurons (BFCNs) projecting to the injured tissue, and the induction of proneurotrophins in the injured cortex promotes axonal degeneration and retrograde neuron loss through p75NTR.
Article
Clinical Neurology
John J. Alam, Paul Maruff, Susan R. Doctrow, Hui-May Chu, Jennifer Conway, Stephen N. Gomperts, Charlotte Teunissen
Summary: This study evaluates the relationship between plasma tau phosphorylated at residue 181 (ptau181), a biomarker of Alzheimer disease (AD) copathology, and the treatment effects of the p38 alpha kinase inhibitor neflamapimod in patients with dementia with Lewy bodies (DLB). The results suggest that DLB patients with lower pretreatment ptau181 levels may show better treatment response to neflamapimod, with improvement in attention, cognitive assessment, and daily functioning. Plasma biomarkers of AD copathology should be considered as stratification variables in DLB clinical trials.
Article
Biology
Blaise Robert, Eyal Y. Kimchi, Yurika Watanabe, Tatenda Chakoma, Miao Jing, Yulong Li, Daniel B. Polley
Summary: Research shows that basal forebrain cholinergic neurons have different functional characteristics in different regions, broadcasting diverse modulatory signals to downstream brain regions.
Article
Neurosciences
Adam Gordon-Fennell, Garret D. Stuber
Summary: Studies have revealed generalizable findings across molecularly defined cell types in areas of the basal forebrain and anterior hypothalamus. Optogenetic stimulation of GABAergic neurons in these brain regions drives reward, while optogenetic stimulation of glutamatergic neurons in these regions drives aversion.
Article
Geriatrics & Gerontology
Shu-hong Jia, Zhi Zhou, Wen Shao, Xiao Zhou, Shuang Lv, Wen Hong, Dan-tao Peng
Summary: This study investigated the effects of volume and function of basal forebrain cholinergic neurons on the cognition of superagers. Through morphometric and resting-state functional MRI analysis, it was found that superagers had stronger connectivity between the basal forebrain and specific brain regions, which was correlated with their superior performance in global cognition and domains of memory and executive function.
Article
Neurosciences
Aaron Kucinski, Cassandra Avila, Martin Sarter
Summary: The study indicates that there are differences in cognitive-behavioral styles between sign tracking and goal tracking, with different projection systems influencing attentional performance. Goal tracking relies on basal forebrain activity and is associated with model-based performance.
Article
Neurosciences
Ken T. Wakabayashi, Malte Feja, Ajay N. Baindur, Michael J. Bruno, Rohan V. Bhimani, Jinwoo Park, Kathryn Hausknecht, Roh-Yu Shen, Samir Haj-Dahmane, Caroline E. Bass
NEUROPSYCHOPHARMACOLOGY
(2019)
Review
Audiology & Speech-Language Pathology
Daniel L. Drane, Nigel P. Pedersen
BRAIN AND LANGUAGE
(2019)
Article
Medicine, Research & Experimental
Kelly R. Bijanki, Joseph R. Manns, Cory S. Inman, Ki Sueng Choi, Sahar Harati, Nigel P. Pedersen, Daniel L. Drane, Allison C. Waters, Rebecca E. Fasano, Helen S. Mayberg, Jon T. Willie
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Review
Clinical Neurology
Anne Venner, William D. Todd, Jimmy Fraigne, Hannah Bowrey, Ada Eban-Rothschild, Satvinder Kaur, Christelle Anaclet
Editorial Material
Clinical Neurology
Daniel L. Drane, Nigel P. Pedersen
Article
Biochemistry & Molecular Biology
Anne M. J. Verstegen, Nataliya Klymko, Lin Zhu, John C. Mathai, Reina Kobayashi, Anne Venner, Rachel A. Ross, Veronique G. VanderHorst, Elda Arrigoni, Joel C. Geerling, Mark L. Zeidel
Article
Neurosciences
Anne Venner, Takatoshi Mochizuki, Roberto De Luca, Christelle Anaclet, Thomas E. Scammell, Clifford B. Saper, Elda Arrigoni, Patrick M. Fuller
JOURNAL OF NEUROSCIENCE
(2019)
Article
Clinical Neurology
Anne Venner, Rebecca Y. Broadhurst, Lauren T. Sohn, William D. Todd, Patrick M. Fuller
Article
Biochemical Research Methods
Jilin W. J. L. Wang, Fabrizio Lombardi, Xiyun Zhang, Christelle Anaclet, Plamen Ch. Ivanov
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Anne Venner, Roberto De Luca, Lauren T. Sohn, Sathyajit S. Bandaru, Anne M. J. Verstegen, Elda Arrigoni, Patrick M. Fuller
Article
Neurosciences
Malte Feja, Martin P. K. Leigh, Ajay N. Baindur, Justin J. McGraw, Ken T. Wakabayashi, Benjamin F. Cravat, Caroline E. Bass
Article
Multidisciplinary Sciences
Satvinder Kaur, Roberto De Luca, Mudasir A. Khanday, Sathyajit S. Bandaru, Renner C. Thomas, Rebecca Y. Broadhurst, Anne Venner, William D. Todd, Patrick M. Fuller, Elda Arrigoni, Clifford B. Saper
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
William D. Todd, Anne Venner, Christelle Anaclet, Rebecca Y. Broadhurst, Roberto De Luca, Sathyajit S. Bandaru, Lindsay Issokson, Lauren M. Hablitz, Olga Cravetchi, Elda Arrigoni, John N. Campbell, Charles N. Allen, David P. Olson, Patrick M. Fuller
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Roberto De Luca, Stefano Nardone, Kevin P. Grace, Anne Venner, Michela Cristofolini, Sathyajit S. Bandaru, Lauren T. Sohn, Dong Kong, Takatoshi Mochizuki, Bianca Viberti, Lin Zhu, Antonino Zito, Thomas E. Scammell, Clifford B. Saper, Bradford B. Lowell, Patrick M. Fuller, Elda Arrigoni
Summary: This study investigates the mechanisms by which orexin neurons contribute to arousal maintenance and state stability through silencing sleep-promoting neurons. The findings provide alternate insights into the role of orexin neurons in maintaining wakefulness.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mauricio Suarez, Elizabeth J. Cantrell, Ken T. Wakabayashi, Caroline E. Bass
Summary: Rat intravenous self-administration is an important animal model in the study of substance use disorders. We have developed an inexpensive and easily manufactured button that reduces the risk of infection.