Article
Engineering, Biomedical
Moyuan Qu, Xiaoling Liao, Nan Jiang, Wujin Sun, Wenqian Xiao, Xingwu Zhou, Ali Khademhosseini, Bo Li, Songsong Zhu
Summary: The study presents a method of alkaline treatment to fabricate open-porous poly (lactic-co-glycolic acid) microspheres as carriers for bone marrow stromal cells, which can enhance cell proliferation and cartilage regeneration, showing improved effects in vitro and in vivo.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Chemistry, Multidisciplinary
Zhenyu Zhao, Zhen Wang, Gen Li, Zhengwei Cai, Jiezhou Wu, Lei Wang, Lianfu Deng, Ming Cai, Wenguo Cui
Summary: Microfluidic hydrogel microspheres have been widely studied and used in various industries, with a focus on their applications in the medical field for controlled delivery of cells and drugs. These materials enable efficient encapsulation and control of functionalities, promoting collaboration across disciplines and advancing precision medicine and applied materials.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Yaoshan Liu, Tong Zhang, Min Li, Zhaoguang Ouyang, Feng Gao, Chunyi Liu, Chen Li, Dayong Liu, Zhimin Zhou
Summary: This study focused on the potential of polymer porous microspheres (PMs) as stem cells delivery carriers for periodontal regeneration. The synthesized PLGA PMs, along with SF and/or HA modifications, were used to seed hPDLSCs with specific techniques. In vitro evaluations showed promising results for cell viability, migration, proliferation, and osteogenic differentiation. In vivo experiments demonstrated the superior tissue repairing efficacy of the HA-SF-PLGA group due to SF-dependent adhesion and HA-dependent osteogenesis.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Biomedical
Xiaohuan Yuan, Wei Yang, Yingying Fu, Ziwei Tao, Lan Xiao, Qinzhou Zheng, Dan Wu, Mengya Zhang, Luxin Li, Zhengmao Lu, Yan Wu, Jie Gao, Yulin Li
Summary: Injection of stem cells can effectively treat diabetic wounds, but shear stress during injections can affect their stemness and growth. Curcumin-loaded porous microspheres containing bone mesenchymal stem cells can promote wound healing by enhancing angiogenesis and inflammation reduction. In vivo experiments demonstrate the improved retention and survival of stem cells in the wound site, accelerating diabetic wound healing.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jiang Bian, Feng Cai, Hao Chen, Zhenzhou Tang, Kun Xi, Jincheng Tang, Liang Wu, Yichang Xu, Lianfu Deng, Yong Gu, Wenguo Cui, Liang Chen
Summary: The injectable peptide-cell-hydrogel microsphere showed promising results in regulating ECM metabolism and inhibiting inflammatory responses, providing an effective approach for tissue regeneration under overactive inflammatory conditions.
Article
Engineering, Environmental
Jinwei Zhong, Qingfei Zhang, Gaizhen Kuang, Jinglin Xia, Luoran Shang
Summary: In this study, novel multicomponent microspheres (MCMs) with co-encapsulation and spatiotemporal drug release capabilities were developed for post-surgical liver cancer treatment and liver regeneration. The MCMs, fabricated via a microfluidic platform, consisted of a sodium alginate shell and gelatin methacrylate cores. The unique particle-in-particle structure allowed for the loading of doxorubicin (DOX) into the shell and augmenter of liver regeneration (ALR) into the cores, enabling rapid release of DOX and more sustained release of ALR. The dual-drug-loaded MCMs showed promising effects in postsurgical tumor killing and promoting liver regeneration, indicating their potential as versatile drug delivery systems for post-surgical cancer therapy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Yueying Yang, Zhengyang Yu, Xiaohuan Lu, Jiahao Dai, Cheng Zhou, Jing Yan, Lin Wang, Zheng Wang, Jianfeng Zang
Summary: We have developed a minimally invasive bioprinting system to fabricate electroactive hydrogel scaffolds in partial liver resection of live rats. In situ tissue regeneration is achieved by promoting cell proliferation, migration, and differentiation, as well as maintaining liver function.
BIOACTIVE MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Chunyan Duan, Mingjia Yu, Changji Hu, Hongying Xia, Ranjith Kumar Kankala
Summary: Tissue engineering aims to restore tissue defects using 3D biomimetic pre-formed scaffolds. Micro-sized injectable modularized units have gained interest as ideal delivery vehicles for cells and growth factors due to their minimally-invasive nature and improved cell retention efficacy. This review discusses the progress of these carriers in tissue engineering, highlighting their design and ability to deliver cells and promote tissue growth.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
Alecsandru Ionescu, Aliona Dodi, Lucian Cristian Petcu, Mihnea Ioan Nicolescu
Summary: This study describes a minimally invasive technique for preserving the post-extraction tooth socket, leading to high implant survival and success rates at five-year follow-up.
Article
Chemistry, Physical
Lilith M. Caballero Aguilar, Serena Duchi, Carmine Onofrillo, Cathal D. O'Connell, Claudia Di Bella, Simon E. Moulton
Summary: Microfluidic systems show great potential in delivering bioactive agents for tissue engineering applications. The fine-tuning of parameters in microfluidic systems is crucial for maximizing encapsulation efficiency and generating bioactive microspheres.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Engineering, Biomedical
Xiongfa Ji, Hongwei Shao, Xiaohong Li, Muhammad Wajid Ullah, Guowen Luo, Ziyang Xu, Limin Ma, Xuecheng He, Zehua Lei, Qian Li, Xulin Jiang, Guang Yang, Yu Zhang
Summary: The inappropriate regeneration of fibrous cartilage and subchondral bone can lead to the failure of cartilage repair. A macrophage-modulated and injectable drug delivery system was developed to promote cartilage and subchondral bone regeneration. This system effectively created a microenvironment that facilitated the regeneration process.
Review
Materials Science, Multidisciplinary
Saeed Siavashy, M. Soltani, Mahnaz Ahmadi, Behnaz Landi, Hedayeh Mehmanparast, Fatemeh Ghorbani-Bidkorbeh
Summary: Novel nanocarriers, such as multifunctional nanoparticles (NPs), have gained attention for their applications in medicine and treatment. Microfluidic (MF) technology offers precise control over flow rates and chemical reaction conditions, enabling the fabrication of uniform and stable particles with higher encapsulation efficiency and controlled release compared to conventional methods. This review explores the MF-based methods for NP synthesis and their advantages in developing innovative drug delivery systems. It also provides a comprehensive comparison with conventional methods, emphasizing the critical characteristics of this new category of nanocarriers. The article summarizes recent representative works on NP fabrication using MF procedures and discusses their potential and applications in drug delivery.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Engineering, Biomedical
Zhuyun Cai, Xiaohao Liu, Miao Hu, Yichen Meng, Jianquan Zhao, Yixuan Tan, Xiong Luo, Ce Wang, Jun Ma, Zhongyi Sun, Yingying Jiang, Bingqiang Lu, Rui Gao, Feng Chen, Xuhui Zhou
Summary: A new biomineralization strategy is developed to prepare magnesium-based mineralized microspheres with controllable size and specific functions, showing great potential for bone regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Materials Science, Biomaterials
Jianmin Xue, Chen Qin, Chengtie Wu
Summary: The combination of biomaterials and living cells in tissue engineering has shown unique advantages in tissue regeneration. The advancement of 3D printing technology has further enhanced the design and composition of tissue engineering scaffolds, allowing for easier loading and delivery of living cells.
REGENERATIVE BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ziqi Gao, Tao Sheng, Wentao Zhang, Huiheng Feng, Jicheng Yu, Zhen Gu, Yuqi Zhang
Summary: Microneedles have emerged as a promising platform for transdermal drug delivery. Recent research has shown the potential of using microneedles in combination with cell therapy to address localized conditions and improve treatment efficacy. This study provides an overview of the recent advances, applications, challenges, and future prospects of microneedle-assisted cell delivery.
Review
Biochemistry & Molecular Biology
Samson Afewerki, Thiago Domingues Stocco, Andre Diniz Rosa da Silva, Andre Sales Aguiar Furtado, Gustavo Fernandes de Sousa, Guillermo U. Ruiz-Esparza, Thomas J. Webster, Fernanda R. Marciano, Maria Stromme, Yu Shrike Zhang, Anderson Oliveira Lobo
Summary: Precision medicine allows for tailored treatments, improving the efficiency and accuracy of disease prevention, diagnosis, and treatment. The combination of organ-on-a-chip and bioprinting can address precision medicine challenges and be utilized in the current COVID-19 pandemic for efficient diagnostics and treatments. This convergence enables advances in tools and in vitro models for personalized and faster screening of therapeutics.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Engineering, Biomedical
Liwen Zheng, Yaxian Liu, Lin Jiang, Xiaoping Wang, Yuqin Chen, Lan Li, Mingyu Song, Hongmei Zhang, Yu Shrike Zhang, Ximu Zhang
Summary: This study proposes a new strategy for pulp regeneration by using hydrogel microspheres incorporated with decellularized dental pulp matrix-derived bioactive factors to simulate a pulp-specific three-dimensional microenvironment. The constructed microspheres exhibit favorable plasticity, biocompatibility, and biological performances, and hDPSCs cultured on the microspheres demonstrate enhanced pulp-formation ability. In vivo experiments show that the microspheres facilitate the regeneration of pulp-like tissue and new dentin. The decellularized pulp matrix-derived bioactive factors mediate the multi-directional differentiation of hDPSCs to regenerate the pulp tissue.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Multidisciplinary
Ying Chen, Lin-Fei Chen, Ying Wang, Sheng-Chang Luo, Jian-Tin Zhang, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
Summary: Compared to traditional 3D models, the decellularized extracellular matrix (dECM) derived from cartilage has shown advantages in studying cartilage inflammatory diseases and drug treatment. By replicating the cartilage tissue microenvironment, dECM-based PLGA porous microspheres (dECM-PLGA PMs) were used to create an efficient cartilage inflammation model. Different anti-inflammatory drugs were evaluated for their therapeutic effects, with ICA showing the highest efficacy.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Yuewei Li, Ranjith Kumar Kankala, Lixin Wu, Ai-Zheng Chen, Shi-Bin Wang
Summary: In this study, deep eutectic solvent-based photocurable resins (PCRs) were synthesized and found to be compatible with commercial liquid-crystal display printers. The 3D-printed parts exhibited high optical transparency, stiffness, and thermal resistance, as well as humidity dependent electrical conductivity and mechanical properties. The PCRs also demonstrated self-healing features and solubility for recycling and remolding, enabling the fabrication of precise multifunctional structures with various materials.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Carla Spatola Rossi, Frederic Coulon, Shaohua Ma, Yu Shrike Zhang, Zhugen Yang
Summary: Rapid, sensitive, and selective detection of live pathogens is crucial for quality control and risk assessment. Conventional methods are often complex, expensive, time-consuming, and not suitable for field testing or low-resource settings. Microfluidic devices that integrate laboratory functions in a miniaturized manner have emerged as a promising tool for rapid and sensitive pathogen detection.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Biomedical
Chunyang Zhang, Xiaochang Lu, Cuiting Lian, Xiongya Li, Hao Liu, Longge Hu, Ranjith Kumar Kankala, Aizheng Chen, Shibin Wang, Chaoping Fu
Summary: This study designed galactosylated sodium alginate (G-SA) material with improved galactose grafting rate to enhance the adherence behavior of HepG2 cells on alginate substrate. G-SA showed good biocompatibility and significantly enhanced cell adhesion. Furthermore, G-SA material was suitable for 3D printing and could be effective for engineering liver cancer models.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Review
Engineering, Biomedical
Biao-Qi Chen, Yi Zhao, Yang Zhang, Yu-Jing Pan, Hong-Ying Xia, Ranjith Kumar Kankala, Shi-Bin Wang, Gang Liu, Ai-Zheng Chen
Summary: This article reviews the challenges in nano-immunotherapy related to immune elimination and immunosuppressive microenvironment in cancer treatment. To address these issues, immune-regulating camouflaged nanocomposites have emerged as prevailing strategies. The article discusses the composition, performances, and mechanisms of various immune-regulating nanoplatforms and their applications in cancer immunotherapy and other immunotherapeutic modalities.
BIOACTIVE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Zewen Kang, Junyu Zhang, Xiaohua Guo, Yangfan Mao, Zhimin Yang, Ranjith Kumar Kankala, Peng Zhao, Ai-Zheng Chen
Summary: Metal oxides have attracted significant interest as catalysts in various reactions, and transmission electron microscopy (TEM) has been used to study their morphology, phase, structure, and chemical information. Recent advances in liquid-phase TEM have enabled the real-time imaging of metal oxides in solution, allowing for the characterization of their dynamic structure, morphology, and composition under working conditions. This review introduces the recent progress in liquid cells, specifically closed liquid cell chips, and discusses the advances in particle growth, phase transformation, self-assembly, core-shell nanostructure growth, and chemical etching. The application of liquid-phase TEM in understanding fundamental processes of metal oxides for CO2 reduction and water-splitting reactions is also highlighted, along with the future outlook and challenges in this research field.
Article
Chemistry, Multidisciplinary
Hao Liu, Biao-Qi Chen, Chang-Yong Li, Cun-Jiong Fang, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
Summary: A method for producing fluoride-free Ti3C2Tx using a ternary solution has been reported, and the excellent performance of fluoride-free Ti3C2Tx in supercapacitors and electromagnetic interference shielding has been demonstrated.
Article
Acoustics
Pei-Yao Xu, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen
Summary: The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have become a global concern in the treatment of bacterial infections. Sonodynamic therapy, a noninvasive and effective therapeutic strategy using sonosensitizer and ultrasound, offers a new approach to combat antibiotic-resistant bacteria and biofilms. Researchers are designing sonosensitizer-loaded nanoplatforms with high SDT efficiency.
ULTRASONICS SONOCHEMISTRY
(2023)
Review
Engineering, Biomedical
Gang Ren, Xia Zhou, Ruimin Long, Maobin Xie, Ranjith Kumar Kankala, Shibin Wang, Yu Shrike Zhang, Yuangang Liu
Summary: In this review, the formation mechanism of magnetosomes and various modification methods are discussed. The biomedical advancements of bacterial magnetosomes in biomedical imaging, drug delivery, anticancer therapy, and biosensors are presented. Future applications and challenges are also discussed. This review summarizes the application of magnetosomes in the biomedical field, highlighting the latest advancements and exploring the future development.
BIOACTIVE MATERIALS
(2023)
Article
Multidisciplinary Sciences
Riccardo Levato, Oksana Dudaryeva, Carlos Ezio Garciamendez-Mijares, Bruce E. Kirkpatrick, Riccardo Rizzo, Jacob Schimelman, Kristi S. Anseth, Shaochen Chen, Marcy Zenobi-Wong, Yu Shrike Zhang
Summary: Light-based vat-polymerization bioprinting allows computer-aided patterning of 3D cell-laden structures using photoactivatable bioresin in vats. This technology, divided into stereolithography, digital light processing and volumetric additive manufacturing, has been widely developed and applied in biomedicine. This Primer introduces the methodology and variations of light-based vat-polymerization 3D bioprinting, as well as discusses key assessments and future directions of this method.
NATURE REVIEWS METHODS PRIMERS
(2023)
Article
Materials Science, Biomaterials
Youyu Duan, Peiyao Xu, Panyuan Ge, Linfei Chen, Ying Chen, Ranjith Kumar Kankala, Shibin Wang, Aizheng Chen
Summary: This study successfully achieved synergistic antibacterial treatment and promoted healing of infected wounds through the construction of a carrier-free nanoparticle that responds to near-infrared light.
REGENERATIVE BIOMATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Sajjad Rahmani Dabbagh, Misagh Rezapour Sarabi, Mehmet Tugrul Birtek, Nur Mustafaoglu, Yu Shrike Zhang, Savas Tasoglu
Summary: Organ-on-a-chip (OOC) platforms provide a more realistic environment compared to animal models and conventional cell cultures, offering continuous perfusion of cell cultures, integration of biosensors, and 3D structures fabricated through bioprinting. These platforms have great potential for understanding organ functions, studying disease impacts, and drug screening. This review presents an overview of bioprinting techniques, their advantages and limitations, recent advancements, applications, and future prospects of the 3D-bioprinted OOC platforms, as well as current challenges and future directions.
