Review
Biochemistry & Molecular Biology
Carolyn G. Chen, Renato Iozzo
Summary: The extracellular matrix (ECM) plays a critical role in maintaining tissue homeostasis and has a significant impact on cancer initiation and progression. The emerging field of matrix biology focuses on the role of proteoglycans in regulating autophagy, a cellular process that has complex and context-dependent functions in cancer.
Article
Cell Biology
Thomas Neill, Christopher Xie, Renato V. Iozzo
Summary: This study demonstrates that Decorin triggers mitochondrial depolarization in several types of cells, including breast carcinoma, HeLa, and endothelial cells. The bioactivity of Decorin is mediated by the MET receptor and its tyrosine kinase, as well as two mitochondrial proteins, mitostatin and mitofusin 2.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Orthopedics
Zakary M. Beach, Kelsey A. Bonilla, Mihir S. Dekhne, Mei Sun, Thomas H. Adams, Sheila M. Adams, Stephanie N. Weiss, Ashley B. Rodriguez, Snehal S. Shetye, David E. Birk, Louis J. Soslowsky
Summary: It was found in mature mice that knockdown of biglycan led to extensive changes in tendon structure and mechanics, while knockdown of decorin had minimal effects. Specifically, biglycan knockdown resulted in reductions in several mechanical parameters and increased collagen fiber realignment during loading. Furthermore, both decorin and biglycan knockdown led to similar alterations in tendon microstructure.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Reproductive Biology
Priyadarshini Pantham, Don L. Armstrong, Jonathan Bodnariuc, Owen Haupt, Amy Wagoner Johnson, Lori Underhill, Renato Iozzo, Beatrice E. Lechner, Derek E. Wildman
Summary: The study identified that in DKO mice, cell cycle arrest leads to a lack of cell proliferation in fetal membranes, resulting in the inability to contain the growing fetus and leading to preterm birth.
BIOLOGY OF REPRODUCTION
(2021)
Review
Oncology
Valentina Diehl, Lisa Sophie Huber, Jonel Trebicka, Malgorzata Wygrecka, Renato V. Iozzo, Liliana Schaefer
Summary: Decorin and biglycan play critical roles in tumor biology by influencing key processes that affect tumor growth and progression. Despite their structural homology, these proteoglycans interact with different cell surface receptors, modulating distinct signaling pathways that ultimately impact cancer development.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Liliana Schaefer, Ivan Dikic
Summary: Recent research has shown the crucial regulatory roles of the extracellular matrix (ECM) in autophagy, with various ECM-derived proteoglycans and proteins inducing or suppressing autophagy. Developing ECM-derived therapeutics selectively regulating autophagy holds vast pharmacological potential.
Article
Orthopedics
B. Han, Q. Li, C. Wang, P. Chandrasekaran, Y. Zhou, L. Qin, X. S. Liu, M. Enomoto-Iwamoto, D. Kong, R. V. Iozzo, D. E. Birk, L. Han
Summary: In post-traumatic osteoarthritis (PTOA), decorin plays a more crucial role than biglycan in regulating cartilage degeneration, while biglycan is more important in regulating subchondral bone structure. The two have distinct activities and modest synergy in the pathogenesis of PTOA.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Multidisciplinary Sciences
Ana Paula Thiesen, Bruna Mielczarski, Ricardo Francalacci Savaris
Summary: This study aimed to compare the protein expression of BGN in breast tissue with and without cancer using immunohistochemistry and deep learning algorithms. The results showed that BGN protein expression was significantly reduced in breast cancer tissue compared to normal tissue.
Article
Obstetrics & Gynecology
Jenna M. Mennella, Lori A. Underhill, Sophia Collis, Geralyn M. Lambert-Messerlian, Richard Tucker, Beatrice E. Lechner
Summary: The levels of serum decorin and biglycan remain stable throughout a healthy pregnancy and are not early indicators of preterm labor, while common MMPs, TIMPs, and collagen VI are also not early indicators of PPROM.
REPRODUCTIVE SCIENCES
(2021)
Article
Immunology
Jeremy Kiripolsky, Eileen M. Kasperek, Chengsong Zhu, Quan-Zhen Li, Jia Wang, Guan Yu, Jill M. Kramer
Summary: Primary Sjogren's syndrome, predominantly seen in women, is characterized by exocrine gland dysfunction and serious systemic manifestations. Research suggests that ECM degradation may represent a novel source of chronic B cell activation in the context of pSS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takato Hara, Tomoko Konishi, Shuji Yasuike, Yasuyuki Fujiwara, Chika Yamamoto, Toshiyuki Kaji
Summary: Vascular endothelial cells synthesize and secrete a large heparan sulfate proteoglycan called perlecan, which enhances the anticoagulant activity of the endothelium and promotes repair of damaged endothelium during the progression of atherosclerosis. The exact regulatory mechanisms of perlecan expression are unclear. In this study, researchers found that a compound called PMTAS promotes perlecan core protein gene expression in vascular endothelial cells without cytotoxicity, providing a useful tool to study the synthesis of perlecan in vascular cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Annukka Pietikainen, Mia Astrand, Julia Cuellar, Otto Glader, Heli Elovaara, Meri Rouhiainen, Jemiina Salo, Tomomi Furihata, Tiina A. Salminen, Jukka Hytonen
Summary: This study found that the binding of Lyme borreliae to human brain microvascular endothelial cells is related to the pathogenesis of neuroborreliosis, suggesting that lysine residues in decorin binding proteins play a crucial role in this process.
MOLECULAR MICROBIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Miaomiao Liu, Wei Wang, Songlin Piao, Yuchen Shen, Zhengmiao Li, Wentong Ding, Jichen Li, Wuliji Saiyin
Summary: This study investigated the expression of BGN and DCN in oral squamous cell carcinoma (OSCC) and found that the up-regulation of BGN and down-regulation of DCN were associated with the malignant degree and survival rate of OSCC.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Cell Biology
Delfien Syx, Sarah Delbaere, Catherine Bui, Adelbert De Clercq, Goran Larson, Shuji Mizumoto, Tomoki Kosho, Sylvie Fournel-Gigleux, Fransiska Malfait
Summary: Proteoglycans, consisting of a core protein and glycosaminoglycan chains, play versatile functions in physiological and pathological processes. The biosynthesis of glycosaminoglycan chains is a complex process involving various enzymes. Deficiencies in these biosynthetic enzymes can lead to severe disorders, such as the Ehlers-Danlos syndromes. This review summarizes the consequences of glycosaminoglycan deficiency in specific types of Ehlers-Danlos syndromes and provides insights into the underlying pathophysiological mechanisms.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Martin Schulz, Valentina Diehl, Jonel Trebicka, Malgorzata Wygrecka, Liliana Schaefer
Summary: Soluble biglycan plays a crucial role in inflammation and autophagy, showing diverse functions in inflammatory kidney diseases and chronic liver diseases. Hepatorenal dysfunction is a common complication in patients with cirrhosis, where soluble biglycan may play a key role.
Article
Biochemistry & Molecular Biology
Simone Buraschi, Thomas Neill, Renato V. Iozzo
Article
Biochemistry & Molecular Biology
Theodoros T. Karalis, Paraskevi Heldin, Demitrios H. Vynios, Thomas Neill, Simone Buraschi, Renato V. Iozzo, Nikos K. Karamanos, Spyros S. Skandalis
Review
Biochemistry & Molecular Biology
Alberto Passi, Davide Vigetti, Simone Buraschi, Renato V. Iozzo
Article
Immunology
Chiara Tobia, Paola Chiodelli, Andrea Barbieri, Simone Buraschi, Elena Ferrari, Stefania Mitola, Giuseppe Borsani, Jessica Guerra, Marco Presta
FRONTIERS IN IMMUNOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Maurizio Mongiat, Simone Buraschi, Eva Andreuzzi, Thomas Neill, Renato Iozzo
BIOCHEMICAL SOCIETY TRANSACTIONS
(2019)
Article
Biochemistry & Molecular Biology
Carolyn G. Chen, Maria A. Gubbiotti, Aastha Kapoor, Xiaorui Han, Yanglei Yu, Robert J. Linhardt, Renato Iozzo
Article
Biochemistry & Molecular Biology
Thomas Neill, Carolyn G. Chen, Simone Buraschi, Renato V. Iozzo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Aastha Kapoor, Carolyn G. Chen, Renato V. Iozzo
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Simone Buraschi, Thomas Neill, Shi-Qiong Xu, Chiara Palladino, Antonino Bel, Renato V. Iozzo, Andrea Morrione
Review
Cell Biology
Thomas Neill, Simone Buraschi, Aastha Kapoor, Renato V. Iozzo
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Liping Mao, Jinxue Yang, Jiaxin Yue, Yang Chen, Hongrui Zhou, Dongdong Fan, Qiuhua Zhang, Simone Buraschi, Renato V. Iozzo, Xiuli Bi
Summary: The study reveals the significant role of a decorin-deficient tumor microenvironment in colon carcinoma progression and metastasis, with promising therapeutic efficacy demonstrated in decorin-deficient animals through a combined Celecoxib/decorin treatment.
Article
Oncology
Tu Dan, Anuradha A. Shastri, Ajay Palagani, Simone Buraschi, Thomas Neill, Jason E. Savage, Aastha Kapoor, Tiziana DeAngelis, Sankar Addya, Kevin Camphausen, Renato Iozzo, Nicole L. Simone
Summary: Research has shown that miR-21 plays a crucial role in the development and treatment of breast cancer, with its knockout inhibiting tumor growth and metastasis, and increasing tumor sensitivity to radiotherapy and chemotherapy.