MicroRNA-21-5p as a novel therapeutic target for osteoarthritis

MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

(2018) Andrea Lampis et al.   GASTROENTEROLOGY

MicroRNA-21 and Dicer are dispensable for hepatic stellate cell activation and the development of liver fibrosis

(2018) Jorge Matias Caviglia et al.   HEPATOLOGY

Cyclin-Dependent Kinase Inhibitor-1-Deficient Mice are Susceptible to Osteoarthritis Associated with Enhanced Inflammation

(2017) Shinsuke Kihara et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis

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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

The role of metabolism in the pathogenesis of osteoarthritis

(2017) Ali Mobasheri et al.   Nature Reviews Rheumatology

Myostatin Promotes Interleukin-1β Expression in Rheumatoid Arthritis Synovial Fibroblasts through Inhibition of miR-21-5p

(2017) Sung-Lin Hu et al.   Frontiers in Immunology

WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

(2016) Giovanna Nalesso et al.   ANNALS OF THE RHEUMATIC DISEASES

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

(2016) Yasuhito Yahara et al.   Nature Communications

Amelioration of Experimental Autoimmune Arthritis Through Targeting of Synovial Fibroblasts by Intraarticular Delivery of MicroRNAs 140-3p and 140-5p

(2016) Jia-Shiou Peng et al.   Arthritis & Rheumatology

Proteinase-activated receptor 2 modulates OA-related pain, cartilage and bone pathology

(2015) Carmen Huesa et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis

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Loss of sclerostin promotes osteoarthritis in mice via β-catenin-dependent and -independent Wnt pathways

(2015) Wafa Bouaziz et al.   ARTHRITIS RESEARCH & THERAPY

Decreased expression of microRNA-21 correlates with the imbalance of Th17 and Treg cells in patients with rheumatoid arthritis

(2014) Liyang Dong et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SF Treg cells transcribing high levels of Bcl-2 and microRNA-21 demonstrate limited apoptosis in RA

(2014) Kornelis S. M. van der Geest et al.   RHEUMATOLOGY

Post-traumatic osteoarthritis: from mouse models to clinical trials

(2013) Christopher B. Little et al.   Nature Reviews Rheumatology

Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging

(2012) Fabiola Olivieri et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Macro view of microRNA function in osteoarthritis

(2012) Shigeru Miyaki et al.   Nature Reviews Rheumatology

The expression and function of microRNAs in chondrogenesis and osteoarthritis

(2011) Tracey E. Swingler et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

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