Distinct profiles of functional discrimination among G proteins determine the actions of G protein–coupled receptors

Buprenorphine–Naloxone Therapy in Pain Management

(2014) Kelly Yan Chen et al.   ANESTHESIOLOGY

RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

(2014) Olga Ostrovskaya et al.   eLife

Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system

(2014) Weiwei Wang et al.   eLife

Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease

(2013) Bruce J. Melancon et al.   DRUG DISCOVERY TODAY

EP2 Receptor Activates Dual G Protein Signaling Pathways that Mediate Contrasting Proinflammatory and Relaxatory Responses in Term Pregnant Human Myometrium

(2013) Mandeep K. Kandola et al.   ENDOCRINOLOGY

Macromolecular Composition Dictates Receptor and G Protein Selectivity of Regulator of G Protein Signaling (RGS) 7 and 9-2 Protein Complexes in Living Cells

(2013) Ikuo Masuho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signalling bias in new drug discovery: detection, quantification and therapeutic impact

(2013) Terry Kenakin et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein   subunits

(2013) P. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate

(2012) Mary P. Hall et al.   ACS Chemical Biology

Deciphering biased-agonism complexity reveals a new active AT1 receptor entity

(2012) Aude Saulière et al.   Nature Chemical Biology

Mutations in GNAL cause primary torsion dystonia

(2012) Tania Fuchs et al.   NATURE GENETICS

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

G protein-coupled receptors for energy metabolites as new therapeutic targets

(2012) Clara C. Blad et al.   NATURE REVIEWS DRUG DISCOVERY

Neuronal Functions of Activators of G Protein Signaling

(2012) Man K. Tse et al.   NEUROSIGNALS

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

(2011) K. Tamura et al.   MOLECULAR BIOLOGY AND EVOLUTION

Two-photon polarization microscopy reveals protein structure and function

(2011) Josef Lazar et al.   NATURE METHODS

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

G protein-coupled receptors: mutations and endocrine diseases

(2011) Gilbert Vassart et al.   Nature Reviews Endocrinology

A mTurquoise-Based cAMP Sensor for Both FLIM and Ratiometric Read-Out Has Improved Dynamic Range

(2011) Jeffrey B. Klarenbeek et al.   PLoS One

Ric-8 Proteins Are Molecular Chaperones That Direct Nascent G Protein   Subunit Membrane Association

(2011) M. Gabay et al.   Science Signaling

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

Detection of Novel Functional Selectivity at M3Muscarinic Acetylcholine Receptors Using aSaccharomyces cerevisiaePlatform

(2010) Gregory D. Stewart et al.   ACS Chemical Biology

RGS6/Gβ5 Complex Accelerates I KACh Gating Kinetics in Atrial Myocytes and Modulates Parasympathetic Regulation of Heart Rate

(2010) Ekaterina Posokhova et al.   CIRCULATION RESEARCH

Differentiation of Human T Cells Alters Their Repertoire of G Protein α-Subunits

(2010) John F. Foley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

M1 and M4 Receptors Modulate Hippocampal Pyramidal Neurons

(2010) Sameera Dasari et al.   JOURNAL OF NEUROPHYSIOLOGY

Functional Selectivity and Biased Receptor Signaling

(2010) T. Kenakin   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

(2010) Christian Lüscher et al.   NATURE REVIEWS NEUROSCIENCE

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity

(2010) N. A. Lambert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

The c-terminus of GRK3 indicates rapid dissociation of G protein heterotrimers

(2009) Bettye Hollins et al.   CELLULAR SIGNALLING

Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist

(2009) Thomas R. H. Büch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fine-tuning of GPCR activity by receptor-interacting proteins

(2009) Stefanie L. Ritter et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders

(2009) P. Jeffrey Conn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Ric-8A, a Gα protein guanine nucleotide exchange factor potentiates taste receptor signaling

(2009) Claire Fenech   Frontiers in Cellular Neuroscience

G protein βγ subunits: Central mediators of G protein-coupled receptor signaling

(2008) A. V. Smrcka   CELLULAR AND MOLECULAR LIFE SCIENCES

Novel Selective Allosteric Activator of the M1 Muscarinic Acetylcholine Receptor Regulates Amyloid Processing and Produces Antipsychotic-Like Activity in Rats

(2008) C. K. Jones et al.   JOURNAL OF NEUROSCIENCE

G Protein Coupling and Signaling Pathway Activation by M1 Muscarinic Acetylcholine Receptor Orthosteric and Allosteric Agonists

(2008) R. L. Thomas et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Differential dissociation of G protein heterotrimers

(2008) Gregory J. Digby et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heterotrimeric G protein activation by G-protein-coupled receptors

(2007) William M. Oldham et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY