Review
Oncology
Riya Su, Xinlin Wu, Liang Tao, Changshan Wang
Summary: Distant metastasis is the main cause of the high mortality rate in colorectal cancer (CRC). Research has found that some epigenetic enzymes are often dysregulated or mutated in multiple tumor types, prompting us to study their roles in CRC metastasis. Existing data suggests that targeting epigenetic enzymes is a promising strategy for treating CRC metastasis.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Review
Biochemistry & Molecular Biology
Sara Paczek, Marta Lukaszewicz-Zajac, Barbara Mroczko
Summary: Colorectal cancer is a common malignancy with heterogeneous characteristics. Despite increased awareness and expanded screening programs, there is still a need for new diagnostic tools for early detection. Classical tumor markers have limited effectiveness in CRC diagnosis, thus the search for new proteins involved in CRC is ongoing. Recent studies suggest the potential significance of granzymes, particularly Granzyme A, in CRC pathogenesis through their involvement in inflammation processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev
Summary: Epigenetic changes associated with histone modifications are important in the emergence and maintenance of various cancer types. Inhibitors of enzymes involved in these modifications are promising for anticancer drug development. This review explores the main features of common histone modifications and their role in malignant neoplasms, discussing strategies for inhibitor development and analyzing the use of multitarget drugs as the most promising strategy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Genetics & Heredity
Rameez Ahmad Khan, Nazia Abbas
Summary: Anthocyanins are important flavonoid compounds in plants, with antioxidant and anti-inflammatory properties. Studies have shown that epigenetic and PTMs modifications of the MBW complex and other transcription factors play a crucial role in regulating anthocyanin biosynthesis in plants. Future research can focus on exploring these regulatory mechanisms to enhance the production of secondary metabolites in medicinal plants.
Review
Biochemistry & Molecular Biology
Sumera Zaib, Nehal Rana, Imtiaz Khan
Summary: Epigenetic regulations, specifically histone modifications, play a crucial role in gene expression and can lead to various diseases when altered. These modifications, such as acetylation, methylation, ribosylation, or phosphorylation, affect the interaction between histone proteins and DNA, consequently altering chromatin structure and gene expression. Cancer and DNA repair mechanisms are particularly influenced by histone methylation.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Immunology
Yingying Lin, Ting Qiu, Guifeng Wei, Yueyue Que, Wenxin Wang, Yichao Kong, Tian Xie, Xiabin Chen
Summary: Inflammation is a defensive reaction to external stimuli in the human body and is associated with various diseases. Histone modifications play a significant role in the regulation of inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Rui Ma, Yinsheng Wu, Shanshan Li, Xilan Yu
Summary: Cancer cells reprogram glucose metabolism to support their proliferation and survival, with pathways like aerobic glycolysis, gluconeogenesis, and the TCA cycle playing crucial roles in regulating cell metabolism, gene expression, apoptosis, and autophagy. Understanding the interplay between cancer cell metabolism and chromatin modifications is essential for developing more effective cancer treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Irina Bure, Marina Nemtsova, Ekaterina B. Kuznetsova
Summary: In recent years, scientists have increasingly suggested and confirmed that epigenetic regulators are closely linked and form a comprehensive network of regulatory pathways and feedback loops. This is particularly important for a better understanding of the development and progression of various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Moe Toyobe, Fumika Yakushiji
Summary: This review introduces synthetic strategies for modifying histones/nucleosomes, including cysteine modifications, transformations of dehydroalanine residues, and lysine acylation using a catalyst system. It also describes the functional evaluation of synthetically modified histones/nucleosomes.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Oncology
Jayden Sterling, Sharleen V. Menezes, Ramzi H. Abbassi, Lenka Munoz
Summary: Histone lysine demethylases (KDMs) are enzymes that remove methylation marks on lysines in nucleosomes' histone tails, regulating gene transcription and playing important roles in cancer development. KDMs can have activating or repressing effects on gene transcription, regulating the expression of oncogenes and tumor suppressors.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Hui Liu, Huimin Ma, Yang Li, Hua Zhao
Summary: This article reviews the current research status of epigenetic modifications in cervical cancer, including DNA methylation, histone modification, noncoding RNA regulation, and chromatin regulation. The functions and molecular mechanisms of these modifications in the occurrence and progression of cervical cancer are also discussed. This review provides new ideas for early screening, risk assessment, molecular targeted therapy, and prognostic prediction of cervical cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Biochemistry & Molecular Biology
Nikolaos Garmpis, Christos Damaskos, Anna Garmpi, Afroditi Nonni, Vasiliki E. Georgakopoulou, Efstathios Antoniou, Dimitrios Schizas, Panagiotis Sarantis, Alexandros Patsouras, Athanasios Syllaios, Christos Vallilas, Evangelos Koustas, Konstantinos Kontzoglou, Nikolaos Trakas, Dimitrios Dimitroulis
Summary: Colorectal cancer is a heterogeneous group of gastrointestinal tract tumors, and its pathogenesis involves multiple factors. Histone deacetylases have been found to be over-expressed in CRC and play an important role in its molecular pathophysiology.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Joanna Szczepanek, Monika Skorupa, Joanna Jarkiewicz-Tretyn, Cezary Cybulski, Andrzej Tretyn
Summary: Breast cancer demonstrates diverse epigenetic abnormalities that impact gene expression and tumor characteristics. Epigenetic alterations are crucial in cancer development and progression, and drugs targeting epigenetic modifications show promise for cancer treatment, including DNA methyltransferase inhibitors, histone-modifying enzymes, and mRNA regulators. However, currently, there is no effective standalone epigenetic drug therapy for breast cancer. Combining epigenetic drugs with conventional therapies has shown positive results, and targeting specific epigenetic changes may lead to more effective monotherapy options in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
