期刊
CURRENT MEDICINAL CHEMISTRY
卷 29, 期 17, 页码 2979-2994出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867328666210915105929
关键词
Histone; deacetylase; inhibitors; HDAC; HDACI; colorectal cancer; targeted therapy; epigenetics
Colorectal cancer is a heterogeneous group of gastrointestinal tract tumors, and its pathogenesis involves multiple factors. Histone deacetylases have been found to be over-expressed in CRC and play an important role in its molecular pathophysiology.
Colorectal cancer (CRC) comprises a heterogeneous group of gastrointestinal tract tumors. It is a multifactorial disease, and a plethora of distinct factors are involved in its pathogenesis and pathophysiology. The development of CRC is not limited to genetic changes, but epigenetic and environmental factors are also involved. Among the epigenetic factors, histone deacetylases (HDACs), a group of epigenetic enzymes that regulate gene expression, have been reported to be over-expressed in CRC. HDACs and their inhibitors seem to play an important role in the molecular pathophysiology of CRC. The aim of this review was to define the role of HDAC inhibitors as potential anticancer agents against CRC.
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