Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice

(2018) Harshini Neelakantan et al.   BIOCHEMICAL PHARMACOLOGY

Obesogenic diets alter metabolism in mice

(2018) Megan R. Showalter et al.   PLoS One

Nicotinamide N -Methyltransferase: More Than a Vitamin B3 Clearance Enzyme

(2017) Pavlos Pissios   TRENDS IN ENDOCRINOLOGY AND METABOLISM

High grade serous ovarian carcinomas originate in the fallopian tube

(2017) S. Intidhar Labidi-Galy et al.   Nature Communications

Phosphoproteomics of Primary Cells Reveals Druggable Kinase Signatures in Ovarian Cancer

(2017) Chiara Francavilla et al.   Cell Reports

Metabolomic characteristics of cholesterol-induced non-obese nonalcoholic fatty liver disease in mice

(2017) Lan N. Tu et al.   Scientific Reports

Profiling Reactive Metabolites via Chemical Trapping and Targeted Mass Spectrometry

(2016) Jae Won Chang et al.   ANALYTICAL CHEMISTRY

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

(2016) Hui Zhang et al.   CELL

Mass-spectrometric exploration of proteome structure and function

(2016) Ruedi Aebersold et al.   NATURE

Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status

(2016) F. Coscia et al.   Nature Communications

Proteomic maps of breast cancer subtypes

(2016) Stefka Tyanova et al.   Nature Communications

Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube

(2016) M. A. Eckert et al.   Cancer Discovery

System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis

(2016) Yair Pozniak et al.   Cell Systems

Systemic alterations in the metabolome of diabetic NOD mice delineate increased oxidative stress accompanied by reduced inflammation and hypertriglyceremia

(2015) Johannes Fahrmann et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition

(2015) Henrik Sperber et al.   NATURE CELL BIOLOGY

Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization

(2015) Shangyu Hong et al.   NATURE MEDICINE

Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion

(2014) Hilary A. Kenny et al.   JOURNAL OF CLINICAL INVESTIGATION

The Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High-performance Quadrupole and an Ultra-high-field Orbitrap Analyzer

(2014) Richard Alexander Scheltema et al.   MOLECULAR & CELLULAR PROTEOMICS

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

(2014) Daniel Kraus et al.   NATURE

Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential

(2014) Cecilia S. Leung et al.   Nature Communications

Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models

(2013) Ruth Perets et al.   CANCER CELL

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink

(2013) Olesya A Ulanovskaya et al.   Nature Chemical Biology

Trends in ultrasensitive proteomics

(2012) AF Maarten Altelaar et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling

(2012) Y. Zong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3

(2012) Y. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs Reprogram Normal Fibroblasts into Cancer-Associated Fibroblasts in Ovarian Cancer

(2012) A. K. Mitra et al.   Cancer Discovery

The volatile compound BinBase mass spectral database

(2011) Kirsten Skogerson et al.   BMC BIOINFORMATICS

TP53 mutations in serous tubal intraepithelial carcinoma and concurrent pelvic high-grade serous carcinoma-evidence supporting the clonal relationship of the two lesions

(2011) Elisabetta Kuhn et al.   JOURNAL OF PATHOLOGY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Mass Spectrometry-based Proteomics Using Q Exactive, a High-performance Benchtop Quadrupole Orbitrap Mass Spectrometer

(2011) Annette Michalski et al.   MOLECULAR & CELLULAR PROTEOMICS

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Targeting the Urokinase Plasminogen Activator Receptor Inhibits Ovarian Cancer Metastasis

(2010) H. A. Kenny et al.   CLINICAL CANCER RESEARCH

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Co-evolution of tumor cells and their microenvironment

(2008) Kornelia Polyak et al.   TRENDS IN GENETICS