Article
Biochemistry & Molecular Biology
Arianna Mazzoli, Maria Stefania Spagnuolo, Martina Nazzaro, Cristina Gatto, Susanna Iossa, Luisa Cigliano
Summary: This study aimed to investigate the effects of fructose consumption on the adolescent brain and verify whether these alterations can be reversed after returning to a normal diet. The findings showed that a short-term fructose-rich diet induced mitochondrial dysfunction and oxidative stress, but these changes were partially recovered by switching back to a control diet.
Article
Biochemistry & Molecular Biology
Nellysha Namela Muhammad Abdul Kadar, Fairus Ahmad, Seong Lin Teoh, Mohamad Fairuz Yahaya
Summary: The supplementation of stingless bee honey (SBH) and pure antioxidant caffeic acid (CA) can reverse the hyperglycemic and hypertensive effects induced by high-carbohydrate high-fructose (HCHF) diet. SBH can significantly reduce brain TNF-alpha levels and increase brain neurotrophic factor BDNF levels.
Article
Neurosciences
Maria Stefania Spagnuolo, Arianna Mazzoli, Martina Nazzaro, Antonio Dario Troise, Cristina Gatto, Claudia Tonini, Mayra Colardo, Marco Segatto, Andrea Scaloni, Valentina Pallottini, Susanna Iossa, Luisa Cigliano
Summary: The study found that fructose intake can lead to inflammation, oxidative stress, mitochondrial dysfunction, and changes in neurotrophins and neurotransmitters in the brain. These alterations persisted even after switching to a healthy diet, highlighting the importance of limiting excessive consumption of sweet foods during adolescence.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Eiji Funajima, Ginga Ito, Eri Ishiyama, Kinji Ishida, Taku Ozaki
Summary: In this study, the mitochondrial localization of a novel mitochondrial calpain, calpain-13, in the mouse brain was investigated. The presence of calpain-13 in both the mitochondrial membrane and soluble fractions was confirmed, and its expression in the cerebral cortex and hippocampus was observed. Further studies on the enzymatic properties and physiological functions of calpain-13 in both the cytosol and mitochondria will provide insights into its potential involvement in neurodegenerative diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Milton D. Chiang Morales, Chao-Yuan Chang, Van Long Le, I-Tao Huang, I-Lin Tsai, Hung-Jen Shih, Chun-Jen Huang
Summary: This study utilized a proteomic approach to investigate the impact of high-fructose plus high-fat diet (HFr/HFD) and high-fat diet (HFD) on liver injury in murine models. The results showed that the hepatic mitochondrial oxidative phosphorylation pathway was significantly downregulated in the HFr/HFD group compared to the HFD group, with alterations in protein levels of specific complexes within the pathway.
Article
Biochemistry & Molecular Biology
Cristina Gatto, Angela Di Porzio, Raffaella Crescenzo, Valentina Barrella, Susanna Iossa, Arianna Mazzoli
Summary: The short-term consumption of a high-fructose diet has a significant impact on skeletal muscle metabolism, with more pronounced effects in young individuals than in adults. The study found that young rats showed marked mitochondrial dysfunction and increased oxidative damage, leading to a decrease in insulin sensitivity. These findings highlight the importance of reducing fructose intake, especially in young people, to maintain metabolic health.
Review
Nutrition & Dietetics
Sarah Gauci, Lauren M. Young, Lizanne Arnoldy, Annie-Claude Lassemillante, Andrew Scholey, Andrew Pipingas
Summary: This systematic review investigated the relationship between dietary patterns in healthy middle-aged adults and neurocognition both in middle age and later in life. The findings were mixed, with some studies reporting a significant positive relationship between adherence to various healthy dietary patterns and neurocognition, but others reporting no such relationship. However, the review suggests that adherence to the Mediterranean diet and other healthy dietary patterns in middle age can protect neurocognition later in life.
Article
Geriatrics & Gerontology
Francesco Bellanti, Vidyasagar Naik Bukke, Archana Moola, Rosanna Villani, Caterina Scuderi, Luca Steardo, Gianmauro Palombelli, Rossella Canese, Sarah Beggiato, Mario Altamura, Gianluigi Vendemiale, Gaetano Serviddio, Tommaso Cassano
Summary: This study investigated the therapeutic potential of ultramicronized palmitoylethanolamide (um-PEA) in 3 x Tg-AD mice. The results showed that um-PEA can improve the complex-I respiration rate and ATPase activity, as well as ATP content in the cortical mitochondria of the mice. However, um-PEA treatment did not improve the mitochondrial bioenergetics impairments and glutamate release in the hippocampus.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Claudia Tonini, Marco Segatto, Francesca Martino, Luisa Cigliano, Martina Nazzaro, Laura Barberio, Maurizio Mandala, Valentina Pallottini
Summary: The study suggests that caloric restriction in late life can partially reverse some age-related changes studied here, but not all impacts can be completely altered.
Article
Biochemistry & Molecular Biology
Alinny Rosendo Isaac, Patricia Coelho de Velasco, Karla Yasmin Dias Fraga, Maria Das Gracas Tavares-do-Carmo, Raquel Maria Pereira Campos, Fabio Arturo Iannotti, Roberta Verde, Danyelly Bruneska Gondim Martins, Thaysa Aragao Santos, Bruna Klippel Ferreira, Fernando Garcia de Mello, Vincenzo Di Marzo, Belmira Lara Da Silveira Andrade-da-Costa, Ricardo Augusto de Melo Reis
Summary: This study investigated the effects of maternal omega-3 PUFA supplementation or deficiency on the endocannabinoid system and synaptic markers in postnatal offspring. The findings suggest that variations in maternal dietary omega-3 PUFA levels may impact differently on the ECS and molecular markers in the cerebral cortex and hippocampus of the progeny.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Zeyu Zhou, Jocelyn Vidales, Jose A. Gonzalez-Reyes, Bradley Shibata, Keith Baar, Jennifer M. Rutkowsky, Jon J. Ramsey
Summary: The study found that a short-term ketogenic diet increased mitochondrial content in the red gastrocnemius muscle, but did not alter mitochondrial content in the liver, prefrontal cortex, or hippocampus. These results indicate tissue-specific changes in mitochondrial mass with a ketogenic diet.
Article
Biochemistry & Molecular Biology
Wembley Rodrigues Vilela, Paula Maria Quaglio Bellozi, Victor Luna Picolo, Bruna Neves Cavadas, Keila Valentina Silva Marques, Louise Tavares Garcia Pereira, Ainhoa Rodriguez de Yurre Guirao, Angelica Amorim Amato, Kelly Grace Magalhaes, Marcia Renata Mortari, Emiliano Horacio Medei, Jair Trape Goulart, Andreza Fabro de Bem
Summary: The study aimed to evaluate the relationship between metabolic and bioenergetic changes induced by a two-hit protocol and cognitive function in mice. The results showed that the two-hit protocol, involving a high-fat diet and low doses of streptozotocin, impaired cognitive function and affected the energy metabolism in brain tissues. These findings highlight the detrimental impact of early overnutrition on cognitive function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Juliana Woyames, Aline Fonseca Pereira Souza, Rosiane Aparecida Miranda, Lorraine Soares Oliveira, Bruna Caetano, Cherley Borba Vieira Andrade, Rodrigo Soares Fortunato, Georgia Correa Atella, Isis Hara Trevenzoli, Luana Lopes Souza, Carmen Cabanelas Pazos-Moura
Summary: Maternal high-fat diet and fructose induced alterations in lipid metabolism and mitochondrial function in skeletal muscle of adult offspring. These changes were modified by maternal diet and fiber type, and were associated with higher skeletal muscle fructose-induced mitochondria injury in adult offspring.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Tae-Woon Kim, Sang-Seo Park, Hye-Sang Park
Summary: This study found that offspring of mothers with advanced maternal age (AMA) without exercise training exhibited poor cognitive function, neuroplasticity, and mitochondrial function compared to offspring of mothers with AMA who underwent exercise training. These findings suggest that exercise contributes to a positive prenatal environment, preventing decreased cognitive function in offspring of mothers with AMA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Mustafa Kutlu Inci, Se-Hyung Park, Robert N. Helsley, Suzanna L. Attia, Samir Softic
Summary: Increased fructose intake, especially in combination with a high-fat diet, can lead to obesity and metabolic complications. Fructose impairs the oxidation of dietary fat by affecting the mitochondrial beta-oxidation pathway and inhibiting the production of acylcarnitine. This explains the synergistic effects of fructose and fat on the development of conditions like non-alcoholic fatty liver disease.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Maria Stefania Spagnuolo, Susanna Iossa, Luisa Cigliano
Summary: Excessive fructose consumption may lead to obesity and metabolic diseases, as well as impact brain health by promoting neuroinflammation and oxidative stress, and causing insulin resistance.
Article
Nutrition & Dietetics
Arianna Mazzoli, Cristina Gatto, Raffaella Crescenzo, Luisa Cigliano, Susanna Iossa
Summary: The study found that unhealthy diets during adolescence can lead to prolonged dysregulation of liver metabolic activity, persisting even after dietary improvements have been made.
Article
Biochemistry & Molecular Biology
Arianna Mazzoli, Maria Stefania Spagnuolo, Martina Nazzaro, Cristina Gatto, Susanna Iossa, Luisa Cigliano
Summary: This study aimed to investigate the effects of fructose consumption on the adolescent brain and verify whether these alterations can be reversed after returning to a normal diet. The findings showed that a short-term fructose-rich diet induced mitochondrial dysfunction and oxidative stress, but these changes were partially recovered by switching back to a control diet.
Article
Nutrition & Dietetics
Claudia Tonini, Marco Segatto, Simona Bertoli, Alessandro Leone, Arianna Mazzoli, Luisa Cigliano, Laura Barberio, Maurizio Mandala, Valentina Pallottini
Summary: This study found that maternal exposure to BPA affects hepatic lipid metabolism in female offspring, and it also reveals the potential impact of BPA on human health at doses currently considered safe.
Review
Physiology
Cristina Gatto, Martina Grandi, Giancarlo Solaini, Alessandra Baracca, Valentina Giorgio
Summary: IF1, as an endogenous inhibitor of ATP synthase, plays a crucial role in limiting ATP dissipation and has emerging roles in cancer and neurodegenerative diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Maria Stefania Spagnuolo, Arianna Mazzoli, Martina Nazzaro, Antonio Dario Troise, Cristina Gatto, Claudia Tonini, Mayra Colardo, Marco Segatto, Andrea Scaloni, Valentina Pallottini, Susanna Iossa, Luisa Cigliano
Summary: The study found that fructose intake can lead to inflammation, oxidative stress, mitochondrial dysfunction, and changes in neurotrophins and neurotransmitters in the brain. These alterations persisted even after switching to a healthy diet, highlighting the importance of limiting excessive consumption of sweet foods during adolescence.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Chiara Galber, Simone Fabbian, Cristina Gatto, Martina Grandi, Stefania Carissimi, Manuel Jesus Acosta, Gianluca Sgarbi, Natascia Tiso, Francesco Argenton, Giancarlo Solaini, Alessandra Baracca, Massimo Bellanda, Valentina Giorgio
Summary: Mitochondrial protein IF1 binds to ATP synthase and inhibits ATP hydrolysis in ischemic tissues. It is overexpressed in tumors and acts as a pro-oncogenic protein. Study found that disruption of ATP5IF1 gene decreases colony formation and tumor mass development in HeLa cells, indicating the role of IF1 in cancer. Lack of IF1 does not affect cell proliferation or mitochondrial respiration, but sensitizes cells to opening of the permeability transition pore (PTP). IF1 binds to ATP synthase OSCP subunit in HeLa cells under oxidative phosphorylation conditions, and this interaction protects cancer cells from PTP-dependent apoptosis under normoxic conditions.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Cristina Gatto, Angela Di Porzio, Raffaella Crescenzo, Valentina Barrella, Susanna Iossa, Arianna Mazzoli
Summary: The short-term consumption of a high-fructose diet has a significant impact on skeletal muscle metabolism, with more pronounced effects in young individuals than in adults. The study found that young rats showed marked mitochondrial dysfunction and increased oxidative damage, leading to a decrease in insulin sensitivity. These findings highlight the importance of reducing fructose intake, especially in young people, to maintain metabolic health.
Article
Biochemistry & Molecular Biology
Arianna Mazzoli, Cristina Gatto, Raffaella Crescenzo, Maria Stefania Spagnuolo, Martina Nazzaro, Susanna Iossa, Luisa Cigliano
Summary: The study found that while temporarily discontinuing the consumption of a diet rich in fructose can fully restore liver function, these changes persist in the gut, especially in the ileum.
