期刊
ANTIOXIDANTS
卷 10, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/antiox10030487
关键词
hippocampus; mitochondria; fructose diet; young rat; inflammation; oxidative stress; haptoglobin; neurofilament-M; PSD-95
资金
- University of Naples Federico II
- FIRB-Futuro in Ricerca grant from the Italian Ministry of University and Research (MUR) [RBFR12QW4I_004]
This study aimed to investigate the effects of fructose consumption on the adolescent brain and verify whether these alterations can be reversed after returning to a normal diet. The findings showed that a short-term fructose-rich diet induced mitochondrial dysfunction and oxidative stress, but these changes were partially recovered by switching back to a control diet.
Young age is often characterized by high consumption of processed foods and fruit juices rich in fructose, which, besides inducing a tendency to become overweight, can promote alterations in brain function. The aim of this study was therefore to (a) clarify brain effects resulting from fructose consumption in juvenile age, a critical phase for brain development, and (b) verify whether these alterations can be rescued after removing fructose from the diet. Young rats were fed a fructose-rich or control diet for 3 weeks. Fructose-fed rats were then fed a control diet for a further 3 weeks. We evaluated mitochondrial bioenergetics by high-resolution respirometry in the hippocampus, a brain area that is critically involved in learning and memory. Glucose transporter-5, fructose and uric acid levels, oxidative status, and inflammatory and synaptic markers were investigated by Western blotting and spectrophotometric or enzyme-linked immunosorbent assays. A short-term fructose-rich diet induced mitochondrial dysfunction and oxidative stress, associated with an increased concentration of inflammatory markers and decreased Neurofilament-M and post-synaptic density protein 95. These alterations, except for increases in haptoglobin and nitrotyrosine, were recovered by returning to a control diet. Overall, our results point to the dangerous effects of excessive consumption of fructose in young age but also highlight the effect of partial recovery by switching back to a control diet.
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