Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment

Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers

(2018) Aleksander M Grabiec et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A phase I trial to determine safety and pharmacokinetics of ASLAN002, an oral MET superfamily kinase inhibitor, in patients with advanced or metastatic solid cancers

(2018) Aflah Roohullah et al.   INVESTIGATIONAL NEW DRUGS

Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

(2018) Eric Ubil et al.   JOURNAL OF CLINICAL INVESTIGATION

The proto-oncogene Mer tyrosine kinase is a novel therapeutic target in mantle cell lymphoma

(2018) Cunzhen Shi et al.   Journal of Hematology & Oncology

Targeting the tumour stroma to improve cancer therapy

(2018) Kenneth C. Valkenburg et al.   Nature Reviews Clinical Oncology

UNC569-induced Morphological Changes in Pigment Epithelia and Photoreceptor Cells in the Retina through MerTK Inhibition in Mice

(2018) Ayako Sayama et al.   TOXICOLOGIC PATHOLOGY

CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3

(2018) Lucía Sanjurjo et al.   Frontiers in Immunology

Antibody Cross-Linking of CD14 Activates MerTK and Promotes Human Macrophage Clearance of Apoptotic Neutrophils: the Dual Role of CD14 at the Crossroads Between M1 and M2c Polarization

(2018) Gaetano Zizzo et al.   INFLAMMATION

Axl Involved in Mineral Trioxide Aggregate Induces Macrophage Polarization

(2018) Hsiao-Wen Yeh et al.   JOURNAL OF ENDODONTICS

Efferocytosis in the tumor microenvironment

(2018) Thomas A. Werfel et al.   Seminars in Immunopathology

Lysyl-tRNA synthetase–expressing colon spheroids induce M2 macrophage polarization to promote metastasis

(2018) Seo Hee Nam et al.   JOURNAL OF CLINICAL INVESTIGATION

The level of synovial AXL expression determines the outcome of inflammatory arthritis, possibly depending on the upstream role of TGF-β1

(2018) Claire E J Waterborg et al.   RHEUMATOLOGY

Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase

(2017) Koji Nomura et al.   JOURNAL OF IMMUNOLOGY

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

Phosphatidylserine Sensing by TAM Receptors Regulates AKT-Dependent Chemoresistance and PD-L1 Expression

(2017) Canan Kasikara et al.   MOLECULAR CANCER RESEARCH

Inhibition of the Receptor Tyrosine Kinase AXL Restores Paclitaxel Chemosensitivity in Uterine Serous Cancer

(2017) Marguerite L. Palisoul et al.   MOLECULAR CANCER THERAPEUTICS

MerTK as a therapeutic target in glioblastoma

(2017) Jing Wu et al.   NEURO-ONCOLOGY

Physiological roles of macrophages

(2017) Siamon Gordon et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice

(2017) J. Lu et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Coordinated balance of Rac1 and RhoA plays key roles in determining phagocytic appetite

(2017) Sang-Yeob Kim et al.   PLoS One

Tumor microenvironment and cancer therapy resistance

(2016) Yu Sun   CANCER LETTERS

U.S. Food and Drug Administration Approval: Cabozantinib for the Treatment of Advanced Renal Cell Carcinoma

(2016) Harpreet Singh et al.   CLINICAL CANCER RESEARCH

Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor–Sensitive and -Resistant Chronic Myeloid Leukemia

(2016) Isabel Ben-Batalla et al.   CLINICAL CANCER RESEARCH

UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia Models

(2016) Deborah DeRyckere et al.   CLINICAL CANCER RESEARCH

Exogenous Gas6 attenuates silica-induced inflammation on differentiated THP-1 macrophages

(2016) Yan Shen et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in Mice

(2016) Lena Seifert et al.   GASTROENTEROLOGY

CD163 + M2-type tumor-associated macrophage support the suppression of tumor-infiltrating T cells in osteosarcoma

(2016) Qinglin Han et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

(2016) Tetsuya Kimura et al.   Nature Communications

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

(2016) Marka R. Crittenden et al.   Oncotarget

The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization

(2016) Florian Finkernagel et al.   Oncotarget

Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages

(2016) Si-Yoon Kim et al.   Scientific Reports

MERTK Inhibition Induces Polyploidy and Promotes Cell Death and Cellular Senescence in Glioblastoma Multiforme

(2016) Alexandra Sufit et al.   PLoS One

Treatment in vitro with PPARα and PPARγ ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice

(2015) Federico Penas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-γ in human macrophage polarization

(2015) Gaetano Zizzo et al.   Journal of Inflammation-London

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

Small Molecule Inhibition of MERTK Is Efficacious in Non-Small Cell Lung Cancer Models Independent of Driver Oncogene Status

(2015) C. T. Cummings et al.   MOLECULAR CANCER THERAPEUTICS

Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation

(2015) Ji-Yeon Choi et al.   Science Signaling

Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia

(2015) Alisa B. Lee-Sherick et al.   Oncotarget

Axl receptor tyrosine kinase is up-regulated in metformin resistant prostate cancer cells

(2015) Nitu Bansal et al.   Oncotarget

Mer receptor tyrosine kinase is frequently overexpressed in human non-small cell lung cancer, confirming resistance to erlotinib

(2015) Shengzhi Xie et al.   Oncotarget

Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation

(2015) Ji-Yeon Choi et al.   Science Signaling

T H 2-Polarized CD4 + T Cells and Macrophages Limit Efficacy of Radiotherapy

(2015) Stephen L. Shiao et al.   Cancer Immunology Research

Overexpression of Tyro3 receptor tyrosine kinase leads to the acquisition of taxol resistance in ovarian cancer cells

(2015) CHUHEE LEE   Molecular Medicine Reports

Macrophage Polarization Reflects T Cell Composition of Tumor Microenvironment in Pediatric Classical Hodgkin Lymphoma and Has Impact on Survival

(2015) Mário H. M. Barros et al.   PLoS One

Mer590, a novel monoclonal antibody targeting MER receptor tyrosine kinase, decreases colony formation and increases chemosensitivity in non-small cell lung cancer

(2015) Christopher T. Cummings et al.   Oncotarget

Axl as a mediator of cellular growth and survival

(2015) Haley Axelrod et al.   Oncotarget

Effect of Apoptotic Cell Recognition on Macrophage Polarization and Mycobacterial Persistence

(2014) Tatiana de Oliveira Fulco et al.   INFECTION AND IMMUNITY

Receptor Tyrosine Kinases, TYRO3, AXL, and MER, Demonstrate Distinct Patterns and Complex Regulation of Ligand-induced Activation

(2014) Wen-I Tsou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution

(2014) Jamie C. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo

(2014) Manikandan Subramanian et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Alternative Macrophage Activation by Galectin-3

(2014) A. C. MacKinnon et al.   JOURNAL OF IMMUNOLOGY

Axl Receptor Blockade Ameliorates Pulmonary Pathology Resulting from Primary Viral Infection and Viral Exacerbation of Asthma

(2014) T. Shibata et al.   JOURNAL OF IMMUNOLOGY

Axl Receptor Blockade Protects from Invasive Pulmonary Aspergillosis in Mice

(2014) Takehiko Shibata et al.   JOURNAL OF IMMUNOLOGY

UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor

(2014) Weihe Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzylidene-indolinones are effective as multi-targeted kinase inhibitor therapeutics against hepatocellular carcinoma

(2014) Han Kiat Ho et al.   Molecular Oncology

Diversification of TAM receptor tyrosine kinase function

(2014) Anna Zagórska et al.   NATURE IMMUNOLOGY

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

A high M1/M2 ratio of tumor-associated macrophages is associated with extended survival in ovarian cancer patients

(2014) Meiying Zhang et al.   Journal of Ovarian Research

Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

(2014) Erin D Lew et al.   eLife

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

(2013) Nadine Jetten et al.   ANGIOGENESIS

MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation

(2013) J. K. Rho et al.   CANCER RESEARCH

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

(2013) J. Xu et al.   CANCER RESEARCH

Molecular Pathways: MERTK Signaling in Cancer

(2013) C. T. Cummings et al.   CLINICAL CANCER RESEARCH

UNC1062, a new and potent Mer inhibitor

(2013) Jing Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological significance and targeting of c-Met tyrosine kinase receptor in cancer 

(2013) Liliane GOETSCH   Frontiers in Bioscience-Landmark

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

(2013) Rebecca S. Cook et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA let-7c Regulates Macrophage Polarization

(2013) S. Banerjee et al.   JOURNAL OF IMMUNOLOGY

Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors

(2013) Weihe Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

UNC569, a Novel Small-Molecule Mer Inhibitor with Efficacy against Acute Lymphoblastic LeukemiaIn VitroandIn Vivo

(2013) Sandra Christoph et al.   MOLECULAR CANCER THERAPEUTICS

Axl Mediates Acquired Resistance of Head and Neck Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Erlotinib

(2013) Keith M. Giles et al.   MOLECULAR CANCER THERAPEUTICS

Xk-Related Protein 8 and CED-8 Promote Phosphatidylserine Exposure in Apoptotic Cells

(2013) J. Suzuki et al.   SCIENCE

Retinoid X receptors in macrophage biology

(2013) Tamás Rőszer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

(2012) Noel A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of highly selective 2,4-diaminopyrimidine-5-carboxamide inhibitors of Sky kinase

(2012) Noel A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Macrophages in Tumor Microenvironments and the Progression of Tumors

(2012) Ning-Bo Hao et al.   Clinical & Developmental Immunology

Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line

(2012) Roudy Chiminch Ekyalongo et al.   INVESTIGATIONAL NEW DRUGS

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells

(2012) Hyun-Jung Park et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting Axl With an High-affinity Inhibitory Aptamer

(2012) Laura Cerchia et al.   MOLECULAR THERAPY

Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer

(2012) R M A Linger et al.   ONCOGENE

Novel and selective spiroindoline-based inhibitors of sky kinase

(2011) Noel A. Powell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Axl receptor tyrosine kinase is an adverse prognostic factor and a therapeutic target in esophageal adenocarcinoma

(2011) Alvarez Hector et al.   CANCER BIOLOGY & THERAPY

Metabolic Connections during Apoptotic Cell Engulfment

(2011) Claudia Z. Han et al.   CELL

Toll-like receptor-mediated inhibition of Gas6 and ProS expression facilitates inflammatory cytokine production in mouse macrophages

(2011) Tingting Deng et al.   IMMUNOLOGY

Galectin-3 is a new MerTK-specific eat-me signal

(2011) Nora B. Caberoy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Differentiation and Glucocorticoid Regulated Apopto-Phagocytic Gene Expression Patterns in Human Macrophages. Role of Mertk in Enhanced Phagocytosis

(2011) Gábor Zahuczky et al.   PLoS One

TAM receptors and the clearance of apoptotic cells

(2010) Greg Lemke et al.   Annals of the New York Academy of Sciences

The novel receptor tyrosine kinase Axl is constitutively active in B-cell chronic lymphocytic leukemia and acts as a docking site of nonreceptor kinases: implications for therapy

(2010) A. K. Ghosh et al.   BLOOD

Induction, regulation, and biologic function of Axl receptor tyrosine kinase in Kaposi sarcoma

(2010) R. Liu et al.   BLOOD

R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

(2010) S. J. Holland et al.   CANCER RESEARCH

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis

(2010) Nora B Caberoy et al.   EMBO JOURNAL

Secondary necrosis: The natural outcome of the complete apoptotic program

(2010) Manuel T. Silva   FEBS LETTERS

Autoimmune Kidney Disease and Impaired Engulfment of Apoptotic Cells in Mice with Macrophage Peroxisome Proliferator-Activated Receptor   or Retinoid X Receptor   Deficiency

(2010) T. Roszer et al.   JOURNAL OF IMMUNOLOGY

RhoA-mediated signaling up-regulates hepatocyte growth factor gene and protein expression in response to apoptotic cells

(2010) Hyun-Jung Park et al.   JOURNAL OF LEUKOCYTE BIOLOGY

TNF-α, IL-6, and IL-1 expression is inhibited by GAS6 in monocytes/macrophages

(2010) Federica Alciato et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AXL regulates mesothelioma proliferation and invasiveness

(2010) W-B Ou et al.   ONCOGENE

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

(2010) X Ye et al.   ONCOGENE

HPV16 Tumor Associated Macrophages Suppress Antitumor T Cell Responses

(2009) A. P. Lepique et al.   CLINICAL CANCER RESEARCH

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

M2 Macrophages Phagocytose Rituximab-Opsonized Leukemic Targets More Efficiently than M1 Cells In Vitro

(2009) M. Leidi et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoids Induce Protein S-Dependent Phagocytosis of Apoptotic Neutrophils by Human Macrophages

(2009) A. McColl et al.   JOURNAL OF IMMUNOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

(2008) L. A. Truman et al.   BLOOD

Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a “come-and-get-me” signal

(2008) David R. Gude et al.   FASEB JOURNAL

In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation

(2008) Jason G. Weinger et al.   JOURNAL OF NEUROCHEMISTRY

Arginase I Induction by Modified Lipoproteins in Macrophages: A Peroxisome Proliferator-Activated Receptor-γ/δ-Mediated Effect that Links Lipid Metabolism and Immunity

(2008) Alejandro Gallardo-Soler et al.   MOLECULAR ENDOCRINOLOGY