Article
Polymer Science
Maria Herrero-Herrero, Jose Antonio Gomez-Tejedor, Ana Valles-Lluch
Summary: Tailored membranes with a fiber diameter of 1.8 μm were electrospun from PLGA and PCLGA solutions by adjusting electrospinning and polymer solution parameters. PCLGA, with its amorphous morphology, required the addition of a salt to increase conductivity for successful electrospinning, presenting notable difficulties due to its structure. Interestingly, PCLGA, with a higher glycolic acid molar fraction, could be successfully electrospun, a feat not previously reported.
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is widely used in various biomedical applications due to its biodegradability and biocompatibility. This study successfully developed a method to synthesize syndioenriched, alternating PLGA from racemic methyl-glycolide (rac-MeG), and confirmed the high degree of alternation of the comonomer sequence and moderate syndiotacticity within the polymer backbone stereoconfiguration through NMR investigations.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Yiye Lu, Geoffrey W. Coates
Summary: Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable and biocompatible polymer used in biomedical applications. This study presents a method for synthesizing syndioenriched, alternating PLGA from racemic methyl-glycolide with the use of an optimized racemic aluminum catalyst. The resulting material has a high degree of alternation in copolymer sequence and moderate syndiotacticity, and is amorphous, making it suitable for drug complexation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Polymer Science
Hong Wang, Yanwei Zhang, Yaru Liu, Yi Ren, Jianhong Wang, Baolong Niu, Wenfeng Li
Summary: This paper focuses on the development of targeted drug delivery systems for cancer therapy. HA-SS-PLGA copolymer was used to form reduction-sensitive amphiphilic micelles, which actively targeted tumor cells and inhibited cancer cell proliferation. This research provides a promising drug carrier for cancer therapy.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Tianzhen Li, Zijian Tan, Zijing Tang, Pi Liu, Haifeng Liu, Leilei Zhu, Yanhe Ma
Summary: An efficient method for synthesizing glycolic acid was reported in this study, utilizing a catalytic C-C coupling reaction of formaldehyde and selective oxidation, with an evolved enzyme showing improved activity at high formaldehyde concentrations.
Article
Pharmacology & Pharmacy
Seung-No Hong, Minjae Kim, Jin-A Park, Minji Kang, Hyunkyung Cha, Sohyun Park, Joon Kon Kim, Jinyoung Pac, Yuju Seo, Sungwhan Kim, Minju Kim, Dae Woo Kim, Yan Lee
Summary: This study designed dexamethasone-loaded poly(lactic-co-glycolic acid) microparticles with bone-specific binding affinity for the treatment of sinus surgery-induced osteitis in chronic rhinosinusitis (CRS). The microparticles released the encapsulated dexamethasone in a sustained manner on the exposed bone after the surgical wound in the nasal cavity. The results showed that the microparticles had higher binding affinity and inhibited the formation of undesirable new woven bone. Therefore, this localized corticoid delivery method has the potential to treat CRS-related osteitis with minimal side effects.
Article
Chemistry, Physical
Shuguang Xu, Qing Tian, Yuan Xiao, Wenyu Zhang, Shengqi Liao, Jianmei Li, Changwei Hu
Summary: This study investigates the control of complex reaction networks in glycerol conversion and achieves selective production of lactic acid or glycolic acid. Bases play a crucial role in promoting reactions and controlling competitive reactions. The mechanisms of different bases and catalysts in glycerol conversion are revealed with computational support.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Steven D. Newby, Chris Forsynth, Austin J. Bow, Shawn E. Bourdo, Man Hung, Joseph Cheever, Ryan Moffat, Andrew J. Gross, Frank W. Licari, Madhu S. Dhar
Summary: Tissue-engineering technologies using PLGA and graphene nanoparticles were evaluated for bone regeneration in vitro and in a rat model of femur defect. The constructs exhibited biocompatibility and promoted mineralized tissue formation. MicroCT and histological analyses confirmed bone repair in rats treated with PLGA + cells construct, supported by Von Kossa staining.
Review
Pharmacology & Pharmacy
Yabing Hua, Yuhuai Su, Hui Zhang, Nan Liu, Zengming Wang, Xiang Gao, Jing Gao, Aiping Zheng
Summary: PLGA is a candidate drug delivery polymer with excellent properties for sustained drug release, and its different characteristics can benefit therapeutic effects. Various factors such as organic phase, continuous phase, emulsifying stage, and solidification process must be considered during manufacturing. Continuous production may be a potential solution for achieving consistency in batches.
Article
Cell Biology
Jai-Shin Liu, Wei-Kai Fang, Shan-Min Yang, Meng-Chen Wu, Tsan-Jan Chen, Chih-Ming Chen, Tung-Yueh Lin, Kai-Lun Liu, Chien-Ming Wu, Yun-Ching Chen, Chih-Pin Chuu, Ling-Yu Wang, Hsing-Pang Hsieh, Hsing-Jien Kung, Wen-Ching Wang
Summary: Myricetin, identified as a potent alpha-ketoglutarate-type inhibitor, blocks the demethylation activity by KDM4s and reduces the proliferation of both androgen-dependent and androgen-independent CRPC cells. A synergistic cytotoxic effect is observed for the combination of myricetin and enzalutamide on CRPC cells. PLGA-encapsulated myricetin in combination with enzalutamide shows significant antitumor activity in a CRPC xenograft model, suggesting its potential effectiveness for CRPC.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Rong Wang, Xiaojie Sun, Lanlan Chen, Wenbin Liang
Summary: In this study, biodegradable blends of PGA and PBAT with in situ compatibilization using MDI were prepared. The addition of PBAT was found to increase the complex viscosity and storage modulus of the blends, leading to improved compatibility and impact strength. The morphology of the dispersed phase evolved from spherical structure to in situ microfiber, enhancing interfacial adhesion and improving toughness.
Article
Polymer Science
Alastair Little, Alan M. Wemyss, David M. Haddleton, Bowen Tan, Zhaoyang Sun, Yang Ji, Chaoying Wan
Summary: The study investigates the effects of various reaction conditions on the synthesis of PLGA25, showing how factors such as reaction temperature, initiator concentration, and catalyst concentration impact the molecular weight, monomer conversion, and thermal properties.
Article
Biochemistry & Molecular Biology
Chao Lv, Shupin Luo, Wenjing Guo, Liang Chang
Summary: This study successfully enhanced the interfacial interaction, crystallization, and mechanical performance of PLA-based biocomposites by using a combination of wood fiber and a self-assembly nucleating agent. The self-assembly nucleating agent formed a dendritic-like structure on the wood fiber surface through hydrogen bonding, promoting the epitaxial crystallization of the PLA matrix and improving the interfacial adhesion. The flexural strength and notched impact strength of the PLA composites increased by 10% and 69%, respectively, under the optimal nucleating agent content.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Yongxuan Chen, Kefeng Xie, Yucheng He, Wenbing Hu
Summary: The study reports the isothermal crystallization kinetics of poly(glycolic acid) (PGA) and compares it to poly((L)-lactic acid) (PLLA). It was found that PGA generally crystallizes more quickly than PLLA, which is attributed to the smaller hydrogen side group of PGA and the differences in molecular mobility and packing between the two polymers.
Article
Polymer Science
Tej Singh, Amar Patnaik, Lalit Ranakoti, Gabor Dogossy, Laszlo Lendvai
Summary: In this study, the effects of wood waste content on the thermal and dry sliding wear properties of PLA biocomposites were investigated. It was found that the inclusion of wood waste reduced the wear of the composites, with the wood waste content being the most crucial parameter affecting the wear of PLA biocomposites.
Article
Engineering, Biomedical
E. Askari, I. F. Cengiz, J. L. Alves, B. Henriques, P. Flores, M. C. Fredel, R. L. Reis, J. M. Oliveira, F. S. Silva, J. Mesquita-Guimaraes
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Review
Engineering, Chemical
Mario Escobar, Bruno Henriques, Marcio C. Fredel, Filipe S. Silva, Mutlu Ozcan, Julio C. M. Souza
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
(2020)
Article
Materials Science, Composites
G. Miranda, B. Guimaraes, D. Pereira, M. Buciumeanu, A. Cabral, M. Fredel, F. S. Silva, B. Henriques
JOURNAL OF COMPOSITE MATERIALS
(2020)
Article
Materials Science, Multidisciplinary
Francisco Cavilha Neto, Marcio Celso Fredel, Milton Pereira, Luiz Eduardo dos Santos Paes
JOURNAL OF LASER APPLICATIONS
(2020)
Article
Materials Science, Ceramics
R. S. F. Pereira, C. G. Moura, B. Henriques, J. Chevalier, F. S. Silva, M. C. Fredel
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2020)
Article
Materials Science, Multidisciplinary
Caroline P. Martendal, Claudio A. Silveira, Milton Pereira, Marcio C. Fredel
JOURNAL OF LASER APPLICATIONS
(2020)
Article
Materials Science, Biomaterials
Vivian Ines dos Santos, Claudia Merlini, Aguedo Aragones, Karina Cesca, Marcio Celso Fredel
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2020)
Article
Materials Science, Characterization & Testing
Vanessa Oliveira Castro, Marcio Celso Fredel, Aguedo Aragones, Guilherme Mariz de Oliveira Barra, Karina Cescac, Claudia Merlini
Review
Engineering, Chemical
Claudia Angela Maziero Volpato, Oscar Carvalho, Mutlu Ozcan, Marcio Celso Fredel, Filipe Samuel Silva
Summary: This study evaluated the bond strength and failure mode of zirconia surfaces treated by laser irradiation, finding that laser treatment can enhance bond strength regardless of the laser type used. Among various treatment methods, tribochemical silica coating and airborne-particle abrasion demonstrated superior bond strength results.
JOURNAL OF ADHESION SCIENCE AND TECHNOLOGY
(2021)
Article
Materials Science, Ceramics
Marcelo Dal Bo, Maykon Cargnin, Bruna N. de Souza, Wenceslau F. das Neves, Marcio C. Fredel, Dachamir Hotza
Summary: This study investigates the application of ion exchange technology in industrial porcelain tiles, successfully enhancing the flexural strength by controlling process parameters such as temperature, immersion time, and chemical composition. Through numerical simulation, a diffusion coefficient of potassium ions into the porcelain tile microstructure was estimated to be about 10 times higher than in glasses.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mario Escobar, Julio C. M. Souza, Guilherme M. O. Barra, Marcio C. Fredel, Mutlu Ozcan, Bruno Henriques
Summary: The combined effect of sulfuric acid etching and acidic adhesive conditioning significantly improved the shear bond strength of PEEK to a resin-matrix composite, demonstrating a synergistic effect between the two methods.
Article
Materials Science, Ceramics
Claudia A. M. Volpato, Oscar Carvalho, Guilherme M. Volpato, Marcio C. Fredel, Filipe S. Silva, Mario Rui da C. Pereira
Summary: This study evaluated the fluorescence changes of white zirconia immersed in coloring and fluorescence liquids, subjected to glass infiltration and aging. Results showed higher reflectance in the glass infiltrated groups, with the fluorescence liquids containing Bi2O3 and Cl, and the fluorescence effect being more pronounced than in the coloring liquid.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Multidisciplinary
Adriano de Souza Pinto Pereira, Jhonattan Gutjahr, Milton Pereira, Ulrich Tetzlaff, Marcio Celso Fredel
Summary: The processability of pure Inconel X750 and Inconel X750 mixed with 15 vol. % of titanium carbide particulate through laser-directed energy deposition (l-DED) was evaluated. This study presents the difficulties in processing thin quadri-modal powder and proposes measures to mitigate them. It also reports, for the first time, on the l-DED processing of Inconel X750 and related metal matrix composites (MMC).
JOURNAL OF LASER APPLICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mariane Beatriz Sordi, Marcio Celso Fredel, Ariadne Cristiane Cabral da Cruz, Paul Thomas Sharpe, Ricardo de Souza Magini
Summary: This study evaluated the effectiveness of hydrogel-based scaffolds embedded with PTH-loaded MBG on bone tissue regeneration in vitro. The results showed that the scaffolds exhibited consistent morphology and physicochemical properties, as well as bioactivity, biocompatibility, and osteoinductivity. These findings suggest that these scaffolds have potential for future 3D printing studies.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Materials Science, Composites
Mutlu Oezcan, Dachamir Hotza, Marcio Celso Fredel, Ariadne Cruz, Claudia Angela Maziero Volpato
Summary: Preventive and regenerative techniques using porous three-dimensional structures composed of bioabsorbable ceramics have been suggested to minimize the aesthetic and functional effects caused by intraoral bone defects. Biodegradable polymers such as cellulose and collagen can also be used to stimulate bone formation, while hybrid scaffolds combine the properties of ceramic materials and biodegradable polymers. Various manufacturing techniques, including 3D printing, can be used to create scaffolds with optimal porosity.
JOURNAL OF COMPOSITES SCIENCE
(2021)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)