Obesity is associated with impaired responsiveness to once‐daily low‐dose aspirin and in vivo platelet activation

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

(2018) Mohamad Shebley et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis

(2018) Bianca Rocca et al.   EUROPEAN HEART JOURNAL

Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters

(2018) Cornelis Smit et al.   Expert Opinion on Drug Metabolism & Toxicology

Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials

(2018) Peter M Rothwell et al.   LANCET

The Aspirin Regimens in Essential Thrombocythemia (ARES) phase II randomized trial design: Implementation of the serum thromboxane B2 assay as an evaluation tool of different aspirin dosing regimens in the clinical setting

(2018) Valerio De Stefano et al.   Blood Cancer Journal

Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Severe obesity and bariatric surgery alter the platelet mRNA profile

(2018) Sean P. Heffron et al.   PLATELETS

Type 2 Diabetes, Obesity, and Aspirin Responsiveness ∗

(2017) Carlo Patrono et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Understanding and applying pharmacometric modelling and simulation in clinical practice and research

(2016) Joseph F. Standing   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Comparisons between perivascular adipose tissue and the endothelium in their modulation of vascular tone

(2016) K E Zaborska et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Effect of Roux-en-Y Gastric Bypass Surgery in Morbidly Obese Patients on Pharmacokinetics of (Acetyl)Salicylic Acid and Omeprazole: the ERY-PAO Study

(2016) Lieke Mitrov-Winkelmolen et al.   OBESITY SURGERY

Stress-induced salivary cortisol secretion during hypobaric hypoxia challenge andin vivourinary thromboxane production in healthy male subjects

(2016) Simona Simeoni et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

The Impact of Obesity on the Pharmacology of Medications Used for Cardiovascular Risk Factor Control

(2015) Sowndramalingam Sankaralingam et al.   CANADIAN JOURNAL OF CARDIOLOGY

In Vivo Platelet Activation and Aspirin Responsiveness in Type 1 Diabetes

(2015) Francesco Zaccardi et al.   DIABETES

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

(2015) Prasenjit Manna et al.   Metabolic Syndrome and Related Disorders

Obesity and Cardiovascular Diseases

(2014) Carl J. Lavie et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action

(2014) P. Patrignani et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In vivo prostacyclin biosynthesis and effects of different aspirin regimens in patients with essential thrombocythaemia

(2014) Isabella Squellerio et al.   THROMBOSIS AND HAEMOSTASIS

Are Metabolically Healthy Overweight and Obesity Benign Conditions?

(2013) Caroline K. Kramer et al.   ANNALS OF INTERNAL MEDICINE

Stability of Urinary Thromboxane A2 Metabolites and Adaptation of the Extraction Method to Small Urine Volume

(2013) Francesca Pagliaccia et al.   Clinical Laboratory

In-Hospital Outcomes of Percutaneous Coronary Interventions in Extremely Obese and Normal-Weight Patients

(2013) Saeed Payvar et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Soluble CD40 Ligand in Morbidly Obese Patients

(2013) Juan A. Baena-Fustegueras et al.   JAMA Surgery

The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetes

(2012) B. ROCCA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Impact of Body Weight and Extreme Obesity on the Presentation, Treatment, and In-Hospital Outcomes of 50,149 Patients With ST-Segment Elevation Myocardial Infarction

(2011) Sandeep R. Das et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Improvement of metabolic parameters and vascular function by metformin in obese non-diabetic rats

(2011) N.S. Lobato et al.   LIFE SCIENCES

The role of weight and enteric coating on aspirin response in cardiovascular patients

(2010) A. PEACE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet Cyclooxygenase Inhibition by Low-Dose Aspirin Is Not Reflected Consistently by Platelet Function Assays

(2009) Francesca Santilli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY