4.6 Letter

The role of weight and enteric coating on aspirin response in cardiovascular patients

期刊

JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 8, 期 10, 页码 2323-2325

出版社

WILEY
DOI: 10.1111/j.1538-7836.2010.03997.x

关键词

-

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Pharmacology & Pharmacy

How not to discover a drug-integrins

Dermot Cox

Summary: Despite the immense potential integrins hold in medicine, the investment in anti-integrin drug discovery programs has yielded little results so far. The main reasons for this are the toxicity and limited efficacy of these drugs, as well as the complex pathophysiology of integrins making drug development challenging.

EXPERT OPINION ON DRUG DISCOVERY (2021)

Article Medicine, General & Internal

Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk

Marco Valgimigli, Enrico Frigoli, Dik Heg, Jan Tijssen, Peter Juni, Pascal Vranckx, Yukio Ozaki, Marie-Claude Morice, Bernard Chevalier, Yoshinobu Onuma, Stephan Windecker, Pim A. L. Tonino, Marco Roffi, Maciej Lesiak, Felix Mahfoud, Jozef Bartunek, David Hildick-Smith, Antonio Colombo, Goran Stankovic, Andres Iniguez, Carl Schultz, Ran Kornowski, Paul J. L. Ong, Mirvat Alasnag, Alfredo E. Rodriguez, Aris Moschovitis, Peep Laanmets, Michael Donahue, Sergio Leonardi, Pieter C. Smits

Summary: The study showed that one month of dual antiplatelet therapy was noninferior to continuing therapy for at least 2 additional months in terms of net adverse clinical events and major adverse cardiac or cerebral events in patients with high risk of bleeding after drug-eluting stent implantation; abbreviated therapy also resulted in a lower incidence of major or clinically relevant nonmajor bleeding.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Pharmacology & Pharmacy

Targeting SARS-CoV-2-Platelet Interactions in COVID-19 and Vaccine-Related Thrombosis

Dermot Cox

Summary: COVID-19 is more than pneumonia, with associated coagulopathy and multi-organ failure. Platelet activation and thrombosis are major factors in poor prognosis, and therapeutics targeting the platelet-SARS-CoV-2 interaction have potential in treating COVID-19 and other virus infections.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

The Interdependency and Co-Regulation of the Vitamin D and Cholesterol Metabolism

Tara Warren, Roisin McAllister, Amy Morgan, Taranjit Singh Rai, Victoria McGilligan, Matthew Ennis, Christopher Page, Catriona Kelly, Aaron Peace, Bernard M. Corfe, Mark Mc Auley, Steven Watterson

Summary: The overlap between vitamin D and cholesterol metabolism pathways is significant, yet our understanding of their independent and co-regulation is limited. Research highlights the relationships between vitamin D supplementation, total cholesterol, and LDL-C status, as well as the consistency between latitude, vitamin D, and cholesterol status. Furthermore, some results cannot be explained with current knowledge of molecular mechanisms.
Article Cardiac & Cardiovascular Systems

Using latent class analysis to identify clinical features of patients with occlusive myocardial infarction: Preangiogram prediction remains difficult

Charles Knoery, Katie A. McEwan, Matthew Manktelow, Jonathan Watt, Jamie Smith, Aleeha Iftikhar, Khaled Rjoob, Raymond Bond, Victoria McGilligan, Aaron Peace, Anne McShane, Janet Heaton, Stephen J. Leslie

Summary: Treatment decisions for myocardial infarction (MI) are currently stratified based on the presence or absence of ST elevation on the electrocardiogram. This study aimed to identify features that could help identify occlusive MI (OMI) among non-ST elevation MI (NSTEMI) cases. The study found that OMI patients had fewer comorbidities but higher acute mortality compared to nonocclusive MI. Latent class analysis did not effectively distinguish OMI from non-OMI. Therefore, there is a need for alternative strategies to improve the identification and treatment of OMI patients.

CLINICAL CARDIOLOGY (2022)

Article Cardiac & Cardiovascular Systems

Bioabsorbable polymer drug-eluting stents with 4-month dual antiplatelet therapy versus durable polymer drug-eluting stents with 12-month dual antiplatelet therapy in patients with left main coronary artery disease: the IDEAL-LM randomised trial

Robert-Jan van Geuns, Chang Chun-Chin, Margaret B. McEntegart, Evgeny Merkulov, Evgeny Kretov, Maciej Lesiak, Peter O'Kane, Colm G. Hanratty, Erwan Bressollette, Marc Silvestri, Adrian Wlodarczak, Paul Barragan, Richard Anderson, Aleksey Protopopov, Aaron Peace, Ian Menown, Paul Rocchiccioli, Yoshinobu Onuma, Keith G. Oldroyd

Summary: This study aimed to compare the clinical outcomes in patients undergoing PCI of unprotected left main coronary artery disease using a biodegradable polymer-coated stent followed by 4 months of DAPT versus a durable polymer-coated stent followed by 12 months of DAPT. The results showed that after two years of follow-up, the two treatment strategies were similar in terms of the primary endpoint, but patients using the biodegradable polymer-coated stent experienced more bleeding events.

EUROINTERVENTION (2022)

Article Medicine, Research & Experimental

AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome

Aoife Campbell, Gareth Morris, Albert Sanfeliu, Joana Augusto, Elena Langa, Jaideep C. Kesavan, Ngoc T. Nguyen, Ronan M. Conroy, Jesper Worm, Lukasz Kielpinski, Mads Aaboe Jensen, Meghan T. Miller, Thomas Kremer, Cristina R. Reschke, David C. Henshall

Summary: Angelman syndrome (AS) is a severe neurodevelopmental disorder. Inhibiting miR-134 and possibly other microRNAs may be beneficial in treating clinically relevant phenotypes with a later developmental window in AS.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

Article Infectious Diseases

Epidemiological assessment of SARS-CoV-2 reinfection

Marwa Almadhi, Adel Salman Alsayyad, Ronan Conroy, Stephen Atkin, Abdulla Al Awadhi, Jaffar A. Al-Tawfiq, Manaf AlQahtani

Summary: This study investigated COVID-19 reinfection cases in Bahrain and found that vaccination and previous infection can reduce the severity of reinfection. Male, individuals aged 30-39, and those with a time interval of 9 months or longer after the initial infection were more likely to experience reinfection.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2022)

Article Cardiac & Cardiovascular Systems

Exploring decision making ?noise? when interpreting the electrocardiogram in the context of cardiac cath lab activation

Aaron Peace, Salah S. Al-Zaiti, Dewar Finlay, Victoria McGilligan, Raymond Bond

Summary: This commentary paper discusses the use of electrocardiogram in aiding diagnostic and patient referral decisions in acute care settings. It addresses the factors that contribute to variability and noise in the decision-making process, and suggests potential research questions and tools to mitigate these issues and improve the quality of decisions based on electrocardiogram.

JOURNAL OF ELECTROCARDIOLOGY (2022)

Article Clinical Neurology

Assessment of on-treatment platelet reactivity at high and low shear stress and platelet activation status after the addition of dipyridamole to aspirin in the early and late phases after TIA and ischaemic stroke

S. T. Lim, S. J. X. Murphy, S. M. Murphy, T. Coughlan, D. O'Neill, S. Tierney, B. Egan, D. R. Collins, A. J. McCarthy, S. -y. Lim, D. R. Smith, D. Cox, D. J. H. McCabe

Summary: This study evaluated the ability of dipyridamole to inhibit platelet function/reactivity and activation in patients with ischemic cerebrovascular disease. The results showed that dipyridamole can inhibit platelet function/reactivity under high and low shear stress conditions and is associated with failure of platelet aggregation and an increase in monocyte-platelet complexes.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2022)

Article Computer Science, Artificial Intelligence

Machine learning and the electrocardiogram over two decades: Time series and meta-analysis of the algorithms, evaluation metrics and applications

Khaled Rjoob, Raymond Bond, Dewar Finlay, Victoria McGilligan, Stephen J. Leslie, Ali Rababah, Aleeha Iftikhar, Daniel Guldenring, Charles Knoery, Anne McShane, Aaron Peace, Peter W. Macfarlane

Summary: This study reviewed the application of machine learning (ML) in analyzing electrocardiogram (ECG) data and used time series analysis to study the changing popularity of different ML algorithms over the past two decades. The results showed that the use of ML in analyzing ECG data has been increasing, especially in heart abnormality classification. Support vector machine has been the most commonly used technique in the past decade, but deep learning has been trending upwards since 2018 and is likely to become the leading technique in the coming years. Accuracy was the most frequently used evaluation metric in the reviewed studies.

ARTIFICIAL INTELLIGENCE IN MEDICINE (2022)

Article Medicine, General & Internal

Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial

Markus P. Schlaich, Marc Bellet, Michael A. Weber, Parisa Danaietash, George L. Bakris, John M. Flack, Roland F. Dreier, Mouna Sassi-Sayadi, Lloyd P. Haskell, Krzysztof Narkiewicz, Ji-Guang Wang

Summary: This study evaluated the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension. The results showed that aprocitentan had a blood pressure lowering effect at week 4 and maintained a sustained effect at week 40. The most common adverse event was mild-to-moderate edema or fluid retention.

LANCET (2022)

Article Cardiac & Cardiovascular Systems

What do we mean by complex percutaneous coronary intervention? An assessment of agreement amongst interventional cardiologists for defining complexity

Khaled Rjoob, Victoria McGilligan, Roisin McAllister, Raymond Bond, Gemina J. Doolub, Stephen Leslie, Matthew Manktelow, Charles Knoery, James Shand, Aleeha Iftikhar, Anne A. McShane, Mamas Mamas, Aaron Peace

Summary: This study aimed to evaluate the inter-rater agreement in rating the complexity and risk of percutaneous coronary intervention (PCI). An online survey revealed poor agreement in classifying the complexity level (k=0.1) and fair agreement in classifying the risk level (k=0.31). However, there was good agreement among participants in rating 26 factors for classifying complex PCI.

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2023)

Review Cardiac & Cardiovascular Systems

Personalized Dual Antiplatelet Therapy in Acute Coronary Syndromes: Striking a Balance Between Bleeding and Thrombosis

Jonathan Shpigelman, Anastasia Proshkina, Michael J. Daly, Dermot Cox

Summary: Dual antiplatelet therapy is essential for managing patients with acute coronary syndromes, but there is considerable variability in clinical response. De-escalation strategies can reduce bleeding risk, but the optimal approach is uncertain.

CURRENT CARDIOLOGY REPORTS (2023)

Article Health Care Sciences & Services

Comparing Single-Page, Multipage, and Conversational Digital Forms in Health Care: Usability Study

Aleeha Iftikhar, Raymond R. Bond, Victoria McGilligan, Stephen J. Leslie, Khaled Rjoob, Charles Knoery, Ciara Quigg, Ryan Campbell, Kyle Boyd, Anne McShane, Aaron Peace

Summary: Even in the digital age, hospitals still rely on paper forms for data entry, but digital forms offer better data quality and research opportunities. While digital single-page forms outperformed multipage and conversational forms in usability metrics, there is still a lack of best practices for their design.

JMIR HUMAN FACTORS (2021)

暂无数据