Article
Pharmacology & Pharmacy
Jiaqin Wu, Yuna Qian, Cheng Chen, Fan Feng, Lianhong Pan, Li Yang, Chunli Wang
Summary: This study demonstrated that Hesperetin (HPT) has chondroprotective and anti-inflammatory effects on chondrocytes through the AMPK signaling pathway, inhibiting TNF-alpha-induced cartilage degradation and promoting chondrocyte proliferation. RNA sequencing identified potential molecular targets, with 549 differentially expressed genes, and highlighted the importance of the AMPK pathway in mediating HPT's protective effects. Overall, HPT shows promise as a natural drug for osteoarthritis treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Xinyue Hong, Xiaoqiao Luo, Langhong Wang, Deming Gong, Guowen Zhang
Summary: The inhibitory activity of hesperetin on PPO and their interaction characteristics were investigated. Results showed that hesperetin reversibly inhibited PPO activity, with different IC50 values on monophenolase and diphenolase. Multiple spectroscopic methods and computational simulations were used to study the interaction between PPO and hesperetin. The study provides novel insights into the inhibition of hesperetin on PPO and theoretical guidance for developing flavonoids as PPO inhibitors.
Article
Reproductive Biology
Muhammad Idrees, Vikas Kumar, Abdul Majid Khan, Myeong-Don Joo, Zia Uddin, Keun-Woo Lee, Il-Keun Kong
Summary: This study investigated the mechanism of Cd-induced mitochondrial toxicity in bovine oocytes and embryos and found that activating SIRT1 can mitigate Cd-induced mitochondrial damage. By activating SIRT1 with hesperetin, mitochondrial biogenesis in bovine embryos can be promoted, leading to enhanced embryo development.
Article
Biochemistry & Molecular Biology
Jingda Li, Tianqi Wang, Panpan Liu, Fuyuan Yang, Xudong Wang, Weilong Zheng, Wenlong Sun
Summary: Hesperetin, a citrus flavonoid, demonstrates anti-inflammatory effects in NAFLD by activating the PI3 K/AKT-Nrf2 pathway to alleviate oxidative stress, suppress NF-kappa B activation, and reduce inflammatory cytokine secretion. These findings suggest that hesperetin may be an effective dietary supplement for improving NAFLD by targeting both oxidative stress and inflammation pathways.
Article
Agriculture, Multidisciplinary
Yan Yin, Deming Li, Fang Liu, Xinjing Wang, Yuan Cui, Shilan Li, Xinli Li
Summary: Apple polyphenol extract (APE) has a protective effect against hepatic steatosis and this effect is SIRT1-dependent. APE treatment can alleviate hepatic steatosis, increase the expression of SIRT1, and alter gut microbiota composition.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Si-Wei Wang, Hao Sheng, Yong-Feng Bai, Yuan-Yuan Weng, Xue-Yu Fan, Fang Zheng, Jing-Qi Fu, Feng Zhang
Summary: The study found that flavanones and phytomedicine rich in flavanones play an important role in protecting pancreatic beta cells in advanced diabetes. Targeting histone acetylation by phytomedicine is a potential strategy to delay the development and progression of diabetes. The inhibition of histone acetylation through regulating AMPK-mediated p300 inactivation is critical for the protective role of naringenin and hesperetin.
Article
Oncology
Bohan Li, Qianfeng Chen, Yucong Feng, Tao Wei, Yuxia Zhong, Yuandie Zhang, Qing Feng
Summary: The rhythmic expression of the circadian clock is closely related to the health of the body. Glucose restriction has been found to enhance apoptosis and cell growth delay in NSCLC cells by upregulating the expression of the circadian clock gene Per through the AMPK-SIRT1 pathway. Additionally, a low-carbohydrate ketogenic diet delays tumor progression and restores the normal rhythmic level of Per.
Article
Medicine, Research & Experimental
Panpan Liu, Jinghan Li, Miaomiao Liu, Muqing Zhang, Yucong Xue, Yuanyuan Zhang, Xue Han, Xuan Jing, Li Chu
Summary: This study found that Hesperetin has a protective effect on ISO-induced myocardial ischemia in mice, possibly by modulating oxidative stress, inflammation, and apoptosis pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Yu-Kai Cui, Yi-Xiang Hong, Wei-Yin Wu, Wei-Min Han, Yao Wu, Chan Wu, Gui-Rong Li, Yan Wang
Summary: The study found that acacetin can reduce myocardial hypertrophy by activating the AMPK/PGC-1 alpha signaling pathway through Sirt1, which leads to a decrease in oxidation, inflammation, and apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xi Sun, Yanna Han, Chaorun Dong, Huan Qu, Yahan Yu, Jiaming Ju, Yunlong Bai, Baofeng Yang
Summary: The study found that Daming capsule (DMC) improves cardiac function by increasing mitophagy, inhibiting oxidative stress and inflammatory response in cardiomyocytes, and activating the SIRT1/AMPK signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Jae Eun Park, Ji Sook Han
Summary: In this study, we investigated the effects of HM-chromanone on glucose production in hepatocytes. HM-chromanone was found to inhibit hepatic glucose production, increase glycogen synthesis, and suppress the expression of genes involved in glucose production. These effects were mediated by the activation of AMPK and the phosphorylation of key proteins involved in glucose metabolism.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Hye Gwang Jeong
Summary: Puerarin activates GPER to regulate lipid metabolism and improve hepatic steatosis.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yunyi Zou, Zhanglin Chen, Chenchen Sun, Dong Yang, Zuoqiong Zhou, Xiyang Peng, Lan Zheng, Changfa Tang
Summary: Exercise, particularly swimming, has been shown to decrease lipid accumulation and improve liver pathology in zebrafish fed high-fat diets. The antioxidative effects of swimming include reducing ROS production, decreasing MDA levels, and enhancing the expression of antioxidant genes. Mechanistically, the SIRT1/AMPK signaling pathway and NRF2 activation may be involved in mediating the protective effects of exercise on NAFLD-induced liver damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Deming Li, Yuan Cui, Xinjing Wang, Fang Liu, Xinli Li
Summary: The study showed that apple polyphenol extract (APE) can alleviate fatty acid-induced lipid accumulation in cells by restoring autophagy, inhibiting lipid synthesis, and promoting fatty acid oxidation. This indicates that APE has potential preventive effects on clinical hepatosteatosis by inducing autophagy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hengte Xing, Chuancai Liang, Chenyu Wang, Xiongfeng Xu, Yong Hu, Bo Qiu
Summary: In this study, it was found that metformin inhibits cholesterol synthesis and promotes cholesterol efflux in osteoarthritis chondrocytes by activating the AMPK/SIRT1 pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Zahra Fakhroueian, Sadegh Rajabi, Niloufar Salehi, Mostafa Rezaei Tavirani, Shokoofe Noori, Mitra Nourbakhsh
Summary: The effects of three synthesized ZnO nanofluids on breast cancer stem-like cells were evaluated in this study. The results showed that ZnO nanofluids could decrease the expression of stemness markers, induce apoptosis, and suppress JAK/STAT activity. ZnO-148 exhibited the most effective activity.
Article
Integrative & Complementary Medicine
Zahra Malekpour-Dehkordi, Mitra Nourbakhsh, Minoo Shahidi, Nazanin Sarraf, Roya Sharifi
Summary: This study found that silymarin can reduce lipogenesis and decrease ER stress, showing potential efficacy in the treatment of non-alcoholic fatty liver disease.
JOURNAL OF HERBAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Amin Vaezi, Amir Reza Eghtedari, Banafsheh Safizadeh, Ghasem Ghasempour, Vahid Salimi, Mitra Nourbakhsh, Shima Nazem, Masoumeh Tavakoli-Yaraki
Summary: This study investigated the expression pattern of MMP-9 in primary skeletal tumors and its correlation with tumor characteristics. The results showed that MMP-9 may be involved in the proliferation and invasion of tumors, and could potentially be used for monitoring and treating malignant tumors.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sahar Yarahmadi, Navid Farahmandian, Reza Fadaei, Mehdi Koushki, Elham Bahreini, Saeed Karima, Sepideh Barzin Tond, Azadeh Rezaei, Mitra Nourbakhsh, Soudabeh Fallah
Summary: The study investigated the effects of resveratrol, atorvastatin, and their combination on gene expression in the cholesterol metabolic pathway in fatty liver. The results showed that resveratrol and atorvastatin reduced fat accumulation in the liver and improved blood lipid profiles compared to the control group. The combination therapy had significant effects on the expression of genes related to cholesterol metabolism and miR33.
DNA AND CELL BIOLOGY
(2023)
Article
Cell Biology
Mitra Nourbakhsh, Shokoofe Noori, Zahra Aminzade, Maryam Bayanati, Mehrdad Alemi, Afshin Zarghi
Summary: This study investigated the effects of a novel chalcone derivative MPP in combination with curcumin on the inflammatory pathways in breast and ovarian cancer cells. The results showed that MPP inhibited NF-κB activity, reduced the expression of inflammatory genes, and decreased the levels of proinflammatory cytokines and nitric oxide. These effects were enhanced when MPP was combined with curcumin.
MEDIATORS OF INFLAMMATION
(2023)
Article
Endocrinology & Metabolism
N. Heydari, R. Sharifi, M. Nourbakhsh, P. Golpour
Summary: This study aimed to investigate the expression of lncRNAs TUG1, MALAT1, and MEG3 in patients with type 2 diabetes and their association with biochemical and ER stress parameters. The results showed that the expression of TUG1, MEG3, ATF4, and CHOP genes was significantly increased in patients with diabetes. The expression levels of TUG1 and MEG3 were positively correlated with glycemic control indices and markers of ER stress, suggesting their potential as markers for identifying ER stress in hyperglycemia.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Cell Biology
Reza Ataei Kachouei, Alireza Doagoo, Maral Jalilzadeh, Seyyed Hossein Khatami, Shima Rajaei, Ali Jahanbazi Jahan-Abad, Farzaneh Salmani, Roya Pakrad, Somayeh Mahmoodi Baram, Mitra Nourbakhsh, Mohammad-Amin Abdollahifar, Hojjat Allah Abbaszadeh, Shokoofeh Noori, Mitra Rezaei, Meisam Mahdavi, Mohammad Reza Shahmohammadi, Saeed Karima
Summary: This study investigates the potential of Acetyl-11-keto-beta-boswellic acid (AKBA), an anti-inflammatory compound from Boswellia species, in preventing and treating non-alcoholic fatty liver disease (NAFLD). The results demonstrate that AKBA improves NAFLD-related serum parameters and inflammatory markers, preserves lipid metabolism, improves hepatic steatosis, and suppresses liver inflammation, thus preventing the progression of NAFLD.
Article
Medical Laboratory Technology
Nariman Moradi, Reza Fadaei, Maryam Roozbehkia, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy-Azar, Bagher Larijani
Summary: This study investigated the associations of two newly discovered adipokines, Metrnl and asprosin, with obesity in children and adolescents. The results showed that Metrnl levels were lower in obese children, while asprosin levels were higher. These adipokines were correlated with obesity-related parameters such as BMI and insulin levels. Therefore, Metrnl and asprosin are potential therapeutic targets for obesity and its associated metabolic imbalances.
LABORATORY MEDICINE
(2023)
Article
Neurosciences
Niloufar Salehi, Mitra Nourbakhsh, Shokoofe Noori, Hossein Rezaeizadeh, Afshin Zarghi
Summary: This study investigates the ameliorating effect of Tehranolide (TEH) and Artemisinin (ART) on experimental autoimmune encephalomyelitis (EAE), a commonly used animal model for multiple sclerosis (MS). Both TEH and ART significantly alleviate EAE signs, with TEH showing greater potency. By modulating the expression of genes related to inflammation and myelination, TEH has the potential to be evaluated as an intervention for MS management.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Havva Afshari, Shokoofe Noori, Mitra Nourbakhsh, Azam Daraei, Mahsa Azami Movahed, Afshin Zarghi
Summary: This study aimed to synthesize a novel imidazo[1,2-a]pyridine derivative (MIA) and evaluate its anti-inflammatory activity and effects on NF-κB and STAT3 pathways in MDA-MB-231 and SKOV3 cell lines. The results showed that MIA exerted its anti-inflammatory activity by suppressing NF-κB and STAT3 signaling pathways, and curcumin enhanced all the anti-inflammatory effects of MIA.
Article
Integrative & Complementary Medicine
Alemeh Taheri, Samira Ezzati Mobaser, Pegah Golpour, Mona Nourbakhsh, Masoumeh Tavakoli-Yaraki, Sahar Yarahmadi, Mitra Nourbakhsh
Summary: In this study, the anti-fibrotic effects of hesperetin were investigated by targeting ECM components and matrix metalloproteinase enzymes. The results showed that hesperetin significantly reduced the production of markers of adipose tissue fibrosis and may be considered a potential compound for the treatment of obesity-associated fibrosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Genetics & Heredity
Mohammad Borji, Nikta Dadkhah Nikroo, Zeynab Yousefi, Mona Nourbakhsh, Zohreh Abdolvahabi, Mitra Nourbakhsh, Bagher Larijani, Maryam Razzaghy-Azar
Summary: The gene expression of CHREBP is elevated in individuals with obesity and metabolic syndrome, and it is associated with various metabolic and liver-related parameters.
Meeting Abstract
Endocrinology & Metabolism
Mitra Nourbakhsh, Mona Nourbakhsh, Pegah Golpour, Hosein Momeni, Maryam Razzaghy Azar
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Mona Nourbakhsh, Nastaran Ramezani, Mitra Nourbakhsh, Maryam Razzaghy Azar
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Article
Integrative & Complementary Medicine
Shokoofe Noori, Mitra Nourbakhsh, Hossein Imani, Niloofar Deravi, Niloufar Salehi, Zohreh Abdolvahabi
Summary: This study investigated the potential of using a combination of naringenin and CPT to modulate the immune response and inhibit tumor growth. The results showed promising effects of this combination in regulating immune response and inhibiting tumor growth, possibly through the JAK2/STAT3 signaling pathway.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)