Article
Chemistry, Multidisciplinary
Qian Wang, Meng Xiao, Dianyu Wang, Xiaoxue Hou, Jie Gao, Jinjian Liu, Jianfeng Liu
Summary: This study introduces a synergistic Pt(IV) prodrug that combines dual responsive behavior and dual drug resistance-related pathways deactivation, effectively overcoming drug resistance and improving the efficacy of anticancer drugs through multiple mechanisms.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Yue Yu, Liping Sun, Yanfei Tang, Huixia Zhu, Huai Wang, Hua Xiao, Feng Wang, Wei Tao
Summary: Encapsulating cisplatin in calcium phosphate nanoparticles is challenging due to its low solubility and weak binding affinity. This study presents a unique strategy using a polymer bearing numerous carboxyl side groups and incorporating redox-sensitive cisplatin prodrugs for encapsulation in CPNPs. The encapsulated CPNPs showed enhanced stability and efficacy against cancerous cells compared to free cisplatin and the prodrug alone.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Biomaterials
Peng Xie, Qiao Jin, Yifan Li, Jinbo Zhang, Xiang Kang, Jialin Zhu, Xinzhan Mao, Peiguo Cao, Chaoyong Liu
Summary: This study reports a triple action nanoplatinum drug based on artesunate and cantharidin, which enhances ROS generation, induces DNA damage, and inhibits DNA repair to achieve a high-efficiency killing effect in a single tumor cell.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Ran Zhang, Yueyue Zhang, Liumei Tang, Yixing Xu, Hao Li, Xueping Jiang, Xiangdong Xin, Zhongzheng Gui
Summary: A series of Pt(IV) prodrugs containing a microtubule inhibitor paclitaxel were synthesized and evaluated for their antitumor activity. One of the prodrugs, named Ptxplatin, effectively entered cancer cells and induced DNA damage, cell cycle arrest, and inhibition of cell migration. Furthermore, Ptxplatin caused mitochondrial dysfunction and triggered endoplasmic reticulum stress, ultimately leading to cancer cell death.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Shu-Yu Cheng, Nan-Fu Chen, Zhi-Hong Wen, Zhi-Kang Yao, Kuan-Hao Tsui, Hsiao-Mei Kuo, Wu-Fu Chen
Summary: GST superfamily members like GSTM3 play a crucial role in detoxification and chemotherapeutic resistance in GBM. Knocking down GSTM3 in GBM cells can decrease glycolysis ability, increase TMZ toxicity, and reduce invasion capability, providing new insights into the mechanism of GSTM3 in recurring GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Warin Rangubpit, Eukote Suwan, Danai Sangthong, Kannika Wongpanit, Roger W. Stich, Prapasiri Pongprayoon, Sathaporn Jittapalapong
Summary: In this study, molecular dynamics simulations were conducted to investigate the binding of GTX and GSH to RmGST. It was found that GSH binds tighter and sits rigidly inside the G-site, while GTX occupies both active sites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xingang Li, Yuanting Pang, Yiwang Zhong, Zhandong Cai, Qibin Ma, Ke Wen, Hai Nian
Summary: In this study, a tau-like glutathione transferase family gene named GmGSTU23 was identified in soybean, which showed a concentration-time-specific expression pattern in response to salt stress. Transgenic lines with GmGSTU23 displayed enhanced salt tolerance, root length, and fresh weight compared to the wild type. Changes in glutathione pools and associated enzyme activity were observed, indicating that GmGSTU23 enhances the activity of glutathione transferase to scavenge reactive oxygen species and glutathione, thereby conferring enhanced tolerance to salt stress in plants.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Yuanjiang Wang, Xinyi Wang, Gang Xu, Shaohua Gou
Summary: The CK2 inhibitor HY1 was found to effectively inhibit cancer stem cells in non-small cell lung cancer (NSCLC), and a Pt(II) agent (HY1-Pt) was developed to reverse cisplatin-induced drug resistance. HY1-Pt targets CK2, suppresses DNA damage repair, enhances cellular accumulation of platinum, and inhibits CSCs through the Wnt/beta-catenin signal pathway. In vivo studies show that HY1-Pt has promising pharmacokinetics and higher tumor growth inhibitory efficacy with lower toxicity compared to cisplatin.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Bangtian Xu, Tingting Tong, Xin Wang, Fang Liu, Xiang Zhang, Xiaolei Hu, Xinpeng Li, Xiaolan Yang, Fei Liao
Summary: The linking of ethacrynic acid with ethylenediamine and 1,4-butanediamine produced EDEA and BDEA, which are membrane-permeable divalent pro-inhibitors of glutathione S-transferase (GST). Their divalent glutathione conjugates showed strong inhibition and binding to GSTmu (GSTM) at a fast rate. The activities of GSTM increased in cisplatin-resistant cells compared to susceptible parental cells when probed with BDEA or EDEA. BDEA and EDEA have the potential to be lead compounds for studying cellular GSTM and sensitizing cisplatin-resistant ovarian cancers.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Alessandra Barbanente, Valentina Gandin, Chiara Donati, Carmela Ilaria Pierro, Giovanni Natile, Nicola Margiotta
Summary: Platinum-based drugs have been successful in treating solid tumors, but toxicity and resistance limit their outcomes. Natural products, such as 10-HDA found in royal jelly, are being explored as safe and easily available anti-cancer drugs. In this study, the researchers aimed to combine the functionality of 10-HDA with platinum to develop new compounds with potential anti-cancer activity. The synthesized compounds were characterized and tested for their cytotoxicity against human tumor cell lines. The results showed that some of the new compounds exhibited promising activity against specific tumor cell lines.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Engineering, Biomedical
Wei Jiang, Zuoxiu Tie, Chi Yu, Yu Chen, Dan Liu, Bin Li
Summary: This study constructs a glutathione (GSH)-responsive nanoplatform to inhibit the energy metabolism and lysosomal activity of tumor cells, making tumor cells remain sensitive to cisplatin. By inhibiting the energy metabolism and autophagy-lysosome pathway of tumor cells, the nanoplatform prevents tumor cells from entering a low-energy dormancy state and enhances the chemotherapeutic effect of cisplatin.
Article
Chemistry, Multidisciplinary
Dongbo Guo, Josh Haipeng Lei, Dade Rong, Tesen Zhang, Bohan Zhang, Zikang Tang, Han-Ming Shen, Chu-Xia Deng, Songnan Qu
Summary: This study reports a novel orange light-triggered anti-tumor therapeutic agent based on photoactivatable Pt(IV)-coordinated carbon dots. These carbon dots release cytotoxic Pt(II) species and promote hydroxy radical generation under orange light, efficiently killing cancer cells.
Review
Chemistry, Multidisciplinary
Larasati Larasati, Witri Wahyu Lestari, Maulidan Firdaus
Summary: The conversion of cisplatin Pt(II) into a Pt(IV) complex is a strategy to overcome resistance and side effects. Ligands with bioactivity could target specific cancer cells and enhance cellular uptake. Self-assembled MOFs with high porosity can load drugs and enable controlled release. Combined with prodrugs, MOFs could generate a triple-acting anticancer agent for enhanced treatment.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Xinming Liu, Pan He, Bingtong Tang, Chunsheng Xiao, Xuesi Chen
Summary: In this study, a thiol-responsive polypeptide SO2 prodrug was designed and synthesized, and the anticancer potential of the self-assembled nanoparticles was investigated. The results showed that the prodrug could induce cancer cell apoptosis by releasing SO2, indicating its great potential in tumor eradication.
Article
Chemistry, Multidisciplinary
Beatriz Brito, Maria Rosaria Ruggiero, Thomas W. Price, Milene da Costa Silva, Nuria Genicio, Annah J. Wilson, Olga Tyurina, Veronika Rosecker, Thomas R. Eykyn, Manuel Banobre-Lopez, Graeme J. Stasiuk, Juan Gallo
Summary: Manganese dioxide (MnO2)-based nanostructures were prepared using a one-pot reaction, and Pt(iv) prodrugs were used as redox-responsive theranostics for cancer therapy. The cytotoxicity of these nanostructures was evaluated and found to be as effective as the clinical chemotherapeutic drug cisplatin in 3D cell models. The nanostructures also exhibited strong ON/OFF magnetic resonance (MR) contrast in response to reducing agents and induced a significant and long-lasting T-1 signal enhancement in tumor-bearing mice.
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)