Article
Oncology
Xiaoyi Jiang, Jian Wang, Xichen Zheng, Zhida Liu, Xinyu Zhang, Yuwei Li, Jonathan Wilhelm, Jun Cao, Gang Huang, Jinlan Zhang, Baran Sumer, Jayanthi Lea, Zhigang Lu, Jinming Gao, Min Luo
Summary: Our study found that intratumoral administration of PC7A nanovaccine achieved stronger antitumor immunity and efficacy compared to subcutaneous injection, primarily dependent on CD8(+) cytotoxic T cells. Mechanistic investigation revealed that intratumoral delivery significantly increased the infiltration of antigen-specific T cells in tumors, despite lower systemic T cell levels compared to subcutaneous injection.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Veronica Finisguerra, Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck, Lionel Mignion, Bernard Gallez, Benoit J. van den Eynde
Summary: Despite limitations in certain tumor types and patients, immunotherapies have achieved revolutionary success in cancer treatment. However, the efficacy of immunotherapies is dependent on the viability and functionality of tumor antigen-specific CD8 T cells within the immunosuppressive tumor microenvironment, where oxygen levels are often low. This study reveals that the antidiabetic drug metformin can improve CD8 T cell fitness in hypoxia, increasing their proliferation and cytokine production, and enhancing their infiltration and survival in hypoxic tumor areas. This presents a promising strategy to overcome resistance to immunotherapy in hypoxic and immunosuppressive tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Anders Handrup Kverneland, Christopher Aled Chamberlain, Troels Holz Borch, Morten Nielsen, Sofie Kirial Mork, Julie Westerlin Kjeldsen, Cathrine Lund Lorentzen, Lise Pyndt Jorgensen, Lene Buhl Riis, Christina Westmose Yde, Ozcan Met, Marco Donia, Inge Marie Svane
Summary: This study demonstrated high success rates of TIL expansion and tumor regressions in multiple solid cancer types when combining TIL ACT with CPIs. In vitro tumor reactivity was positively associated with treatment outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Qiyan Wang, Zhipeng Dong, Fangning Lou, Yunxue Yin, Jiahao Zhang, Hanning Wen, Tao Lu, Yue Wang
Summary: The development of peptide-based cancer vaccines has drawn increasing interest for their potential in cancer management, prevention, and treatment. This study focuses on overcoming challenges associated with efficient immune response against cancer, such as lymph node drainage and retention, dendritic cell uptake, and activation. The researchers developed a PBE-modified nanovaccine that effectively targeted lymph nodes, induced dendritic cell maturation, and enhanced T cell immune response against melanoma, resulting in improved antitumor efficacy in prevention and treatment without the need for additional adjuvants.
Article
Chemistry, Multidisciplinary
Ting Su, Furong Cheng, Jialong Qi, Yu Zhang, Shurong Zhou, Lei Mei, Shiwei Fu, Fuwu Zhang, Shuibin Lin, Guizhi Zhu
Summary: pH-responsive CDN/neoantigen codelivering nanovaccines are promising for ICB combination tumor immunotherapy, as they can release antigens and activate immune responses in specific conditions, resulting in strong therapeutic efficacy.
Article
Oncology
Huanhe Ni, Huanling Zhang, Lin Li, He Huang, Hui Guo, Lin Zhang, Chunwei Li, Jing-Xiao Xu, Cai-Ping Nie, Kui Li, Xiaoshi Zhang, Xiaojun Xia, Jiang Li
Summary: In this study, it was found that increased STING and CCL22 levels, as well as higher levels of FOXP3(+) cells and lower levels of CD8(+) cells in tumor tissues of cervical cancer, predicted poor survival. Activation of STING signaling in cooperation with T cell receptor and other signals promoted iTreg differentiation in both human and murine CD4(+) naive T cells. Additionally, tumor-derived exosomes were found to activate STING signaling in tumor-infiltrated T cells, leading to iTreg expansion.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Chemistry, Multidisciplinary
Shanshan Gou, Wenwen Liu, Shuai Wang, Guanyu Chen, Zhenzhen Chen, Lu Qiu, Xiuman Zhou, Yahong Wu, Yuanming Qi, Yanfeng Gao
Summary: STING agonists have shown promise in cancer immunotherapy, but face challenges in drug delivery and side effects. A novel nanovaccine drug-delivery system was developed to effectively deliver STING agonists to dendritic cells and enhance antitumor effects, showing great potential in cancer treatment.
Article
Oncology
Jacob Gadwa, Thomas E. Bickett, Laurel B. Darragh, Michael William Knitz, Shilpa Bhatia, Miles Piper, Benjamin Van Court, Shiv Bhuvane, Diemmy Nguyen, Varuna Nangia, Emily K. Kleczko, Raphael A. Nemenoff, Sana D. Karam
Summary: Inhibition of complement C3a and C5a signaling in HNSCC accelerates tumor growth and increases regulatory T cell populations. Local C3a and C5a signaling is important for CD4 T cell homeostasis and development into effector phenotypes. Depletion of Tregs reverses tumor growth and combining Treg depletion with C3a and C5a receptor inhibition reduces tumor growth further.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Samantha M. Fix, Marie-Andree Forget, Donastas Sakellariou-Thompson, Yunfei Wang, Tamara M. Griffiths, Minjung Lee, Cara L. Haymaker, Ana Lucia Dominguez, Rafet Basar, Christopher Reyes, Sanjay Kumar, Larissa A. Meyer, Patrick Hwu, Chantale Bernatchez, Amir A. Jazaeri
Summary: In this study, we optimized CRISPR/Cas9-mediated knockout of TGF-beta receptor 2 (TGFBR2) in patient-derived ovarian cancer TIL. TGFBR2 knockout TIL showed resistance to immunosuppression and improved cytotoxicity. This lays the groundwork for clinical translation of CRISPR-modified TIL for the treatment of ovarian cancer and other solid cancers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Melani Luque, Marta Sanz-Alvarez, Miriam Morales-Gallego, Juan Madoz-Gurpide, Sandra Zazo, Carolina Dominguez, Alicia Cazorla, Yann Izarzugaza, Juan Luis Arranz, Ion Cristobal, Federico Rojo
Summary: The immune system plays an important role in breast cancer, and tumor-infiltrating lymphocytes (TILs) predict the response to anti-HER2 therapy. The goal is to enhance the patient's immune system for more effective cancer cell killing. However, the effects of immune cells depend on their infiltration in tumors and the communication with tumor cells.
Article
Oncology
Julia Karbach, Dragan Kiselicki, Kathrin Brand, Claudia Wahle, Evgueni Sinelnikov, Dirk Gustavus, Hans Hoffmeister, Hans-Bernd Prisack, Akin Atmaca, Elke Jaeger
Summary: Adoptive transfer of autologous tumor-specific lymphocytes in conjunction with IL-2 and immune-checkpoint blockade led to complete and durable tumor remission in a patient with metastatic hormone-refractory NY-ESO-1 expressing prostate cancer. The treatment resulted in a decrease of tumor-driven NY-ESO-1 serum antibody and prostate-specific antigen, demonstrating the effectiveness of this method for advanced malignancies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Ahmet Murat Aydin, MacLean Hall, Brittany L. Bunch, Holly Branthoover, Zachary Sannasardo, Amy Mackay, Matthew Beatty, Amod A. Sarnaik, John E. Mullinax, Philippe E. Spiess, Shari Pilon-Thomas
Summary: This study demonstrated successful expansion of tumor-reactive TIL from penile cancer patients, supporting the development of ACT strategies using TIL for the treatment of advanced and recurrent penile cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Yu Gao, Qi Luo, Zhichen Sun, Hannan Gao, Yue Yu, Yining Sun, Xiaotu Ma, Chuanhui Han, Jiyun Shi, Fan Wang
Summary: A new SPECT/CT imaging probe Tc-99m-sum IL-2 was developed to target tumor-infiltrating T cells and predict immune response and guide immunotherapy. The probe successfully identified tumor-infiltrating T cells and showed treatment efficacy through imaging.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemical Research Methods
Meng Zhou, Zicheng Zhang, Siqi Bao, Ping Hou, Congcong Yan, Jianzhong Su, Jie Sun
Summary: A machine learning-based computational framework was used to identify a lncRNA signature of TIL-Bs, named TILBlncSig, which showed potential in distinguishing survival outcomes and was associated with cancer features and immunosuppressive phenotype.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Oncology
Yueshui Zhao, Jian Deng, Shuangfeng Rao, Sipeng Guo, Jing Shen, Fukuan Du, Xu Wu, Yu Chen, Mingxing Li, Meijuan Chen, Xiaobing Li, Wanping Li, Li Gu, Yuhong Sun, Zhuo Zhang, Qinglian Wen, Zhangang Xiao, Jing Li
Summary: Cell-based immunotherapy, especially tumor-infiltrating lymphocytes (TILs) therapy, has emerged as a powerful strategy in solid cancer treatment. This review summarizes the current strategies and challenges in TIL generation, and discusses the clinical trials where TIL therapy is used independently or in combination with other therapies for solid tumor treatment. The limitations, future potential, and directions of TIL therapy for solid tumors are also discussed.
Article
Nanoscience & Nanotechnology
Wenjun Wang, Zhida Liu, Xiaoxiao Zhou, Zhenqian Guo, Jing Zhang, Ping Zhu, Sheng Yao, Mingzhao Zhu
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Pathology
Glorimar Rivera-Colon, Hao Chen, Shuang Niu, Elena Lucas, Steven Holloway, Kelley Carrick, Katja Gwin, Jayanthi Lea, Wenxin Zheng
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2020)
Article
Oncology
Kevin Albuquerque, Vasu Tumati, Jayanthi Lea, Chul Ahn, Debra Richardson, David Miller, Robert Timmerman
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Oncology
Lesley B. Conrad, Ken Y. Lin, Tulip Nandu, Bryan A. Gibson, Jayanthi S. Lea, W. Lee Kraus
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniella F. Pinho, Brent King, Yin Xi, Kevin Albuquerque, Jayanthi Lea, Rathan M. Subramaniam
AMERICAN JOURNAL OF ROENTGENOLOGY
(2020)
Article
Oncology
Victoria Perkins, Kathleen Moore, Sara Vesely, Koji Matsuo, Sayedamin Mostofizadeh, Travis T. Sims, Jayanthi Lea, Dominique Barnes, Sixia Chen, Matthew Carlson, Lynda Roman, Bradley J. Monk, Laura L. Holman
GYNECOLOGIC ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Jared Ostmeyer, Elena Lucas, Scott Christley, Jayanthi Lea, Nancy Monson, Jasmin Tiro, Lindsay G. Cowell
Correction
Multidisciplinary Sciences
Zhichen Sun, Zhenhua Ren, Kaiting Yang, Zhida Liu, Shuaishuai Cao, Sisi Deng, Lily Xu, Yong Liang, Jingya Guo, Yingjie Bian, Hairong Xu, Jiyun Shi, Fan Wang, Yang-Xin Fu, Hua Peng
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Lang Rao, Lei Wu, Zhida Liu, Rui Tian, Guocan Yu, Zijian Zhou, Kuikun Yang, Hong-Gang Xiong, Anli Zhang, Guang-Tao Yu, Wenjing Sun, Han Xu, Jingya Guo, Andrew Li, Hongmin Chen, Zhi-Jun Sun, Yang-Xin Fu, Xiaoyuan Chen
NATURE COMMUNICATIONS
(2020)
Article
Gastroenterology & Hepatology
Ameet Thaker, Diana Montoya Melo, Layla Z. Samandi, Rong Huang, Jason Y. Park, Edaire Cheng
Summary: This study compared the clinical and histologic features of different types of eosinophilic gastrointestinal diseases, finding similarities in esophageal fibrosis prevalence between EoE and EGID-SEE, while EGID-MEE and EGID-NEE cases showed no fibrosis. Additionally, a consensus for evaluating LP fibrosis is needed for accurate diagnosis and management.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Cell Biology
Yuzhu Hou, Hua L. Liang, Xinshuang Yu, Zhida Liu, Xuezhi Cao, Enyu Rao, Xiaona Huang, Liangliang Wang, Lei Li, Jason Bugno, Yanbin Fu, Steven J. Chmura, Wenjun Wu, Sean Z. Luo, Wenxin Zheng, Ainhoa Arina, Jessica Jutzy, Anne R. McCall, Everett E. Vokes, Sean P. Pitroda, Yang-Xin Fu, Ralph R. Weichselbaum
Summary: Tumor-induced Ter cells promote tumor progression by secreting ARTN, and local tumor ionizing radiation and anti-PD-L1 treatment can decrease Ter cell abundance and ARTN secretion. Recombinant erythropoietin can restore Ter cell numbers and ARTN concentration, and decreased expression of GFR alpha 3 is associated with favorable outcomes in melanoma patients undergoing immunotherapy. These findings suggest potential targets for improving outcomes after radiotherapy and immunotherapy.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Chuanhui Han, Victoria Godfrey, Zhida Liu, Yanfei Han, Longchao Liu, Hua Peng, Ralph R. Weichselbaum, Hasan Zaki, Yang-Xin Fu
Summary: Research showed that tumors lacking certain molecules in the inflammasome pathway were sensitive to radiation treatment in mice, while dual deficiency in multiple molecules resulted in radioresistance. The study also demonstrated that activation of AIM2 and NLRP3 inflammasomes by irradiated tumors played a role in inducing antitumor effects through IL-1 signaling in dendritic cells.
SCIENCE IMMUNOLOGY
(2021)
Article
Dermatology
Elysha Kolitz, Elena Lucas, Gregory A. Hosler, Jiwoong Kim, Suntrea Hammer, Cheryl Lewis, Lin Xu, Andrew T. Day, Melissa Mauskar, Jayanthi S. Lea, Richard C. Wang
Summary: This study retrospectively analyzed 36 patients with invasive vulvar squamous cell carcinoma and found that HPV-positive tumors showed higher expression of circular RNAs associated with other cancer pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Xinyi Zhang, Frederico O. Gleber-Netto, Shidan Wang, Roberta Rayra Martins-Chaves, Ricardo Santiago Gomez, Nadarajah Vigneswaran, Arunangshu Sarkar, William N. N. William Jr, Vassiliki Papadimitrakopoulou, Michelle Williams, Diana Bell, Doreen Palsgrove, Justin Bishop, John V. V. Heymach, Ann M. M. Gillenwater, Jeffrey N. N. Myers, Renata Ferrarotto, Scott M. M. Lippman, Curtis Rg Pickering, Guanghua Xiao
Summary: Convolutional neural networks-based histology image analysis can accelerate the discovery of better oral cancer progression risk models by predicting the development of oral leukoplakia. This can contribute to early intervention and decrease morbidity and mortality of oral cancer.
Article
Obstetrics & Gynecology
Jessica Grubman, Summer S. Meinhardt, Anjali Nambiar, Jayanthi S. Lea
JOURNAL OF LOWER GENITAL TRACT DISEASE
(2020)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)