Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1)

(2018) Patricia Santofimia-Castaño et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

(2018) Gwen Lomberk et al.   Nature Communications

Low concentration trifluoperazine promotes proliferation and reduces calcium-dependent apoptosis in glioma cells

(2018) Yulin Wen et al.   Scientific Reports

Targeting intrinsically disordered proteins at the edge of chaos

(2018) Hao Ruan et al.   DRUG DISCOVERY TODAY

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

(2018) Patricia Santofimia-Castaño et al.   Scientific Reports

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B

(2017) Patricia Santofimia-Castaño et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

(2017) José L. Neira et al.   Scientific Reports

Determinants of the pKa values of ionizable residues in an intrinsically disordered protein

(2016) José L. Neira et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Biophysical Screening for Identifying Pharmacological Chaperones and Inhibitors Against Conformational and Infectious Diseases

(2016) Adrián Velazquez-Campoy et al.   CURRENT DRUG TARGETS

Knockdown of NUPR1 inhibits the proliferation of glioblastoma cells via ERK1/2, p38 MAPK and caspase-3

(2016) Jun Li et al.   JOURNAL OF NEURO-ONCOLOGY

NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance

(2016) M R Emma et al.   Cell Death & Disease

Lactic acidosis switches cancer cells from aerobic glycolysis back to dominant oxidative phosphorylation

(2016) Hao Wu et al.   Oncotarget

Water Dispersion Interactions Strongly Influence Simulated Structural Properties of Disordered Protein States

(2015) Stefano Piana et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) L R Palam et al.   Cell Death & Disease

Trailing TRAIL Resistance: Novel Targets for TRAIL Sensitization in Cancer Cells

(2015) Rachana Trivedi et al.   Frontiers in Oncology

Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras G12D -induced senescence

(2014) D Grasso et al.   CELL DEATH AND DIFFERENTIATION

Genetic inactivation ofNupr1acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis

(2013) Carla E Cano et al.   GUT

Deciphering the Binding between Nupr1 and MSL1 and Their DNA-Repairing Activity

(2013) David Aguado-Llera et al.   PLoS One

Trifluoperazine, an Antipsychotic Agent, Inhibits Cancer Stem Cell Growth and Overcomes Drug Resistance of Lung Cancer

(2012) Chi-Tai Yeh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lentivirus-Mediated RNAi Knockdown of NUPR1 Inhibits Human Nonsmall Cell Lung Cancer GrowthIn VitroandIn Vivo

(2012) Xiaotong Guo et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis

(2012) Tewfik Hamidi et al.   JOURNAL OF CLINICAL INVESTIGATION

p8 Expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesis

(2011) Maria Jose Sandi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nupr1: The Swiss-knife of cancer

(2010) Carla E. Cano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Stress-inducible Protein p8 Is Involved in Several Physiological and Pathological Processes

(2009) Sandro Goruppi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage

(2009) Meritxell Gironella et al.   JOURNAL OF CELLULAR PHYSIOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation