USP9X deubiquitinates ALDH1A3 and maintains mesenchymal identity in glioblastoma stem cells

The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer

(2018) Omar M. Khan et al.   JOURNAL OF CLINICAL INVESTIGATION

The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization

(2018) Lei Li et al.   ONCOGENE

Inhibition of USP10 induces degradation of oncogenic FLT3

(2017) Ellen L Weisberg et al.   Nature Chemical Biology

The stem cell/cancer stem cell marker ALDH1A3 regulates the expression of the survival factor tissue transglutaminase, in mesenchymal glioma stem cells

(2017) Kelly E. Sullivan et al.   Oncotarget

MiR-215 Is Induced Post-transcriptionally via HIF-Drosha Complex and Mediates Glioma-Initiating Cell Adaptation to Hypoxia by Targeting KDM1B

(2016) Jing Hu et al.   CANCER CELL

Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner

(2016) Sung-Hak Kim et al.   CANCER CELL

The Error-Prone DNA Polymerase κ Promotes Temozolomide Resistance in Glioblastoma through Rad17-Dependent Activation of ATR-Chk1 Signaling

(2016) Chenghao Peng et al.   CANCER RESEARCH

FOXD1–ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells

(2016) Peng Cheng et al.   CANCER RESEARCH

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth

(2016) Baoli Hu et al.   CELL

Regulation of pluripotency and differentiation by deubiquitinating enzymes

(2016) B Suresh et al.   CELL DEATH AND DIFFERENTIATION

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B‐cell lymphoma

(2016) Katharina Engel et al.   EMBO Molecular Medicine

ALDH1A3, a metabolic target for cancer diagnosis and therapy

(2016) Jiang-Jie Duan et al.   INTERNATIONAL JOURNAL OF CANCER

MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

(2016) Syed Arif Abdul Rehman et al.   MOLECULAR CELL

Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms

(2016) F Wolfsperger et al.   Cell Death & Disease

Deubiquitinase USP9X deubiquitinates β-catenin and promotes high grade glioma cell growth

(2016) Bo Yang et al.   Oncotarget

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

(2016) Georg Karpel-Massler et al.   Oncotarget

La FAM fatale: USP9X in development and disease

(2015) Mariyam Murtaza et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Deubiquitinase inhibition as a cancer therapeutic strategy

(2015) Padraig D'Arcy et al.   PHARMACOLOGY & THERAPEUTICS

Deubiquitinase USP9x Confers Radioresistance through Stabilization of Mcl-1

(2015) Donatella Trivigno et al.   NEOPLASIA

Mutations in USP9X Are Associated with X-Linked Intellectual Disability and Disrupt Neuronal Cell Migration and Growth

(2014) Claire C. Homan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Emerging Potential of Therapeutic Targeting of Ubiquitin-Specific Proteases in the Treatment of Cancer

(2014) A. Pal et al.   CANCER RESEARCH

Targeting Self-Renewal in High-Grade Brain Tumors Leads to Loss of Brain Tumor Stem Cells and Prolonged Survival

(2014) Zhe Zhu et al.   Cell Stem Cell

Essential Role of Aldehyde Dehydrogenase 1A3 for the Maintenance of Non-Small Cell Lung Cancer Stem Cells Is Associated with the STAT3 Pathway

(2014) C. Shao et al.   CLINICAL CANCER RESEARCH

Molecular Pathways: Translational Potential of Deubiquitinases as Drug Targets

(2014) P. D'Arcy et al.   CLINICAL CANCER RESEARCH

miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways

(2014) Hui Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X

(2014) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mesenchymal Differentiation Mediated by NF-κB Promotes Radiation Resistance in Glioblastoma

(2013) Krishna P.L. Bhat et al.   CANCER CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

The integrated landscape of driver genomic alterations in glioblastoma

(2013) Veronique Frattini et al.   NATURE GENETICS

Deubiquitylases From Genes to Organism

(2013) Michael J. Clague et al.   PHYSIOLOGICAL REVIEWS

Regulation of T cell function by the ubiquitin-specific protease USP9X via modulating the Carma1-Bcl10-Malt1 complex

(2013) Yoon Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

 -Synuclein fate is determined by USP9X-regulated monoubiquitination

(2011) R. Rott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zymophagy, a Novel Selective Autophagy Pathway Mediated by VMP1-USP9x-p62, Prevents Pancreatic Cell Death

(2010) Daniel Grasso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

USP9X Enhances the Polarity and Self-Renewal of Embryonic Stem Cell-derived Neural Progenitors

(2009) Lachlan A. Jolly et al.   MOLECULAR BIOLOGY OF THE CELL

Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death

(2009) Hiroaki Nagai et al.   MOLECULAR CELL