The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization

DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins

(2017) Hung Thanh Nguyen et al.   PLoS One

USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15

(2016) Michol Giovanna Savio et al.   CURRENT BIOLOGY

TGF-β Targets the Hippo Pathway Scaffold RASSF1A to Facilitate YAP/SMAD2 Nuclear Translocation

(2016) Dafni-Eleftheria Pefani et al.   MOLECULAR CELL

MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1

(2016) Kwang Hwa Jung et al.   STEM CELLS

Deubiquitylating enzyme USP9x regulates radiosensitivity in glioblastoma cells by Mcl-1-dependent and -independent mechanisms

(2016) F Wolfsperger et al.   Cell Death & Disease

Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover

(2016) Hung Thanh Nguyen et al.   Cell Discovery

YAP1 Is a Driver of Myofibroblast Differentiation in Normal and Diseased Fibroblasts

(2015) Bram Piersma et al.   AMERICAN JOURNAL OF PATHOLOGY

Hippo Pathway Regulation of Gastrointestinal Tissues

(2015) Fa-Xing Yu et al.   Annual Review of Physiology

Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies

(2015) L. F. Peterson et al.   BLOOD

ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors

(2015) Liem T. Nguyen et al.   CANCER CELL

A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer

(2015) Björn von Eyss et al.   CANCER CELL

HEATR1 Negatively Regulates Akt to Help Sensitize Pancreatic Cancer Cells to Chemotherapy

(2015) T. Liu et al.   CANCER RESEARCH

Role of Angiomotin-like 2 mono-ubiquitination on YAP inhibition

(2015) M. Kim et al.   EMBO REPORTS

Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway

(2015) Jung-Soon Mo et al.   NATURE CELL BIOLOGY

AMPK modulates Hippo pathway activity to regulate energy homeostasis

(2015) Wenqi Wang et al.   NATURE CELL BIOLOGY

YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate Self-Renewal and Vascular Mimicry of Stem-Like Cells

(2015) Namrata Bora-Singhal et al.   STEM CELLS

YAP and TAZ: a nexus for Hippo signaling and beyond

(2015) Carsten Gram Hansen et al.   TRENDS IN CELL BIOLOGY

Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells

(2015) Upal Basu-Roy et al.   Nature Communications

YAPping About Differentiation Therapy in Muscle Cancer

(2014) Matthew N. Svalina et al.   CANCER CELL

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

(2014) Annie M. Tremblay et al.   CANCER CELL

Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase

(2014) X. Zheng et al.   GENES & DEVELOPMENT

Metabolic control of YAP and TAZ by the mevalonate pathway

(2014) Giovanni Sorrentino et al.   NATURE CELL BIOLOGY

Rescue of Hippo coactivator YAP1 triggers DNA damage–induced apoptosis in hematological cancers

(2014) Francesca Cottini et al.   NATURE MEDICINE

A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

(2013) Morvarid Mohseni et al.   NATURE CELL BIOLOGY

YAP Promotes Breast Cell Proliferation and Survival Partially through Stabilizing the KLF5 Transcription Factor

(2012) Xu Zhi et al.   AMERICAN JOURNAL OF PATHOLOGY

β-Catenin-Driven Cancers Require a YAP1 Transcriptional Complex for Survival and Tumorigenesis

(2012) Joseph Rosenbluh et al.   CELL

PTPN14 is required for the density-dependent control of YAP1

(2012) W. Wang et al.   GENES & DEVELOPMENT

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

(2010) V. Kapuria et al.   CANCER RESEARCH

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

FAM/USP9x, a Deubiquitinating Enzyme Essential for TGFβ Signaling, Controls Smad4 Monoubiquitination

(2009) Sirio Dupont et al.   CELL

Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death

(2009) Hiroaki Nagai et al.   MOLECULAR CELL

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL