Post-translational regulation of ubiquitin signaling

Protein-Injection Machines in Bacteria

(2018) Jorge E. Galán et al.   CELL

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns

(2018) Helen Walden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of parkin activation by phosphorylation

(2018) Véronique Sauvé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RBR ligase–mediated ubiquitin transfer: a tale with many twists and turns

(2018) Helen Walden et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of parkin activation by phosphorylation

(2018) Véronique Sauvé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into catalysis and function of phosphoribosyl-linked serine ubiquitination

(2018) Sissy Kalayil et al.   NATURE

Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector

(2018) Anil Akturk et al.   NATURE

Structural basis of ubiquitin modification by the Legionella effector SdeA

(2018) Yanan Dong et al.   NATURE

Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation

(2018) Tara EC Condos et al.   EMBO JOURNAL

Legionella pneumophila inhibits immune signalling via MavC-mediated transglutaminase-induced ubiquitination of UBE2N

(2018) Ninghai Gan et al.   Nature Microbiology

Dynamic ubiquitin signaling in cell cycle regulation

(2017) Samuel Gilberto et al.   JOURNAL OF CELL BIOLOGY

ISGylation – a key to lock the cell gates for preventing the spread of threats

(2017) Carolina Villarroya-Beltri et al.   JOURNAL OF CELL SCIENCE

Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

(2017) Chun-Song Yang et al.   MOLECULAR CELL

Legionella and Coxiella effectors: strength in diversity and activity

(2017) Jiazhang Qiu et al.   NATURE REVIEWS MICROBIOLOGY

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function

(2017) Naoe T. Nihira et al.   Science Signaling

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function

(2017) Naoe T. Nihira et al.   Science Signaling

The Roles of MDM2 and MDMX in Cancer

(2016) Orit Karni-Schmidt et al.   Annual Review of Pathology-Mechanisms of Disease

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

(2016) Sagar Bhogaraju et al.   CELL

E2 enzymes: more than just middle men

(2016) Mikaela D Stewart et al.   CELL RESEARCH

Bacteria-host relationship: ubiquitin ligases as weapons of invasion

(2016) Timurs Maculins et al.   CELL RESEARCH

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Ubiquitin chain diversity at a glance

(2016) Masato Akutsu et al.   JOURNAL OF CELL SCIENCE

Ubiquitination independent of E1 and E2 enzymes by bacterial effectors

(2016) Jiazhang Qiu et al.   NATURE

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

Ubc13: the Lys63 ubiquitin chain building machine

(2016) Curtis D. Hodge et al.   Oncotarget

A Ubl/ubiquitin switch in the activation of Parkin

(2015) V. Sauve et al.   EMBO JOURNAL

Expanding the ubiquitin code through post-translational modification

(2015) L. Herhaus et al.   EMBO REPORTS

The three ‘P’s of mitophagy: PARKIN, PINK1, and post-translational modifications

(2015) Thomas M. Durcan et al.   GENES & DEVELOPMENT

Ubiquitin in the activation and attenuation of innate antiviral immunity

(2015) Steven M. Heaton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PARPs and ADP-Ribosylation: 50 Years … and Counting

(2015) W. Lee Kraus   MOLECULAR CELL

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

Protein neddylation: beyond cullin–RING ligases

(2015) Radoslav I. Enchev et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination

(2015) Michael J. Sheedlo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

Ubiquitin acetylation inhibits polyubiquitin chain elongation

(2014) F. Ohtake et al.   EMBO REPORTS

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

Novel bacterial ADP-ribosylating toxins: structure and function

(2014) Nathan C. Simon et al.   NATURE REVIEWS MICROBIOLOGY

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity

(2014) A. Persaud et al.   Science Signaling

Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

(2014) E. Seto et al.   Cold Spring Harbor Perspectives in Biology

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

Versatile Roles of K63-Linked Ubiquitin Chains in Trafficking

(2014) Zoi Erpapazoglou et al.   Cells

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

c-Abl Phosphorylates E6AP and Regulates Its E3 Ubiquitin Ligase Activity

(2013) Ai-Leen Chan et al.   BIOCHEMISTRY

Auto-ubiquitination of Mdm2 Enhances Its Substrate Ubiquitin Ligase Activity

(2013) Ruchira S. Ranaweera et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Antiviral Activities of ISG15

(2013) David J. Morales et al.   JOURNAL OF MOLECULAR BIOLOGY

The N-Terminal Extension of UBE2E Ubiquitin-Conjugating Enzymes Limits Chain Assembly

(2013) Frances-Rose Schumacher et al.   JOURNAL OF MOLECULAR BIOLOGY

Status of Large-scale Analysis of Post-translational Modifications by Mass Spectrometry

(2013) Jesper V. Olsen et al.   MOLECULAR & CELLULAR PROTEOMICS

Monoubiquitination of Filamin B Regulates Vascular Endothelial Growth Factor-Mediated Trafficking of Histone Deacetylase 7

(2013) Y.-T. Su et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response

(2012) Takahito Sanada et al.   NATURE

Structural mechanism of ubiquitin and NEDD8 deamidation catalyzed by bacterial effectors that induce macrophage-specific apoptosis

(2012) Q. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms

(2011) P de Bie et al.   CELL DEATH AND DIFFERENTIATION

Regulation of the Human Papillomavirus Type 18 E6/E6AP Ubiquitin Ligase Complex by the HECT Domain-Containing Protein EDD

(2011) V. Tomaic et al.   JOURNAL OF VIROLOGY

Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors

(2011) A. T. Sasaki et al.   Science Signaling

Comparative Proteomic Analysis Identifies a Role for SUMO in Protein Quality Control

(2011) M. H. Tatham et al.   Science Signaling

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

Post-translational modifications in signal integration

(2010) Yonathan Lissanu Deribe et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Correction for Gallagher et al., Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

(2010)   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

(2010) J. Cui et al.   SCIENCE

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The Enteropathogenic Escherichia coli Effector Cif Induces Delayed Apoptosis in Epithelial Cells

(2009) A. Samba-Louaka et al.   INFECTION AND IMMUNITY

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin proteolytic system: focus on SUMO

(2008) Van G Wilson et al.   Expert Review of Proteomics

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY