The unique trimeric assembly of the virulence factor HtrA from Helicobacter pylori occurs via N-terminal domain swapping

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Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials

(2018) Xinming Yang et al.   PLOS BIOLOGY

Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation

(2018) Nicole Albrecht et al.   Frontiers in Microbiology

Targeting Helicobacter pylori urease activity and maturation: In-cell high-throughput approach for drug discovery

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Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

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Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA

(2016) Thomas P. Schmidt et al.   Gut Pathogens

Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA

(2016) Thomas P. Schmidt et al.   Scientific Reports

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Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor ofHelicobacter PyloriHtrA

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Integrin Engagement by the Helical RGD Motif of theHelicobacter pyloriCagL Protein Is Regulated by pH-induced Displacement of a Neighboring Helix

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Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA

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Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site

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Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal toChlamydia trachomatis

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Distinct Roles of Secreted HtrA Proteases from Gram-negative Pathogens in Cleaving the Junctional Protein and Tumor Suppressor E-cadherin

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NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

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Cage assembly of DegP protease is not required for substrate-dependent regulation of proteolytic activity or high-temperature cell survival

(2012) S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into Helicobacter pylori oncoprotein CagA interaction with  1 integrin

(2012) B. Kaplan-Turkoz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid paracellular transmigration of Campylobacter jejuni across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA cleaving E-cadherin but not fibronectin

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Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages

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(2011) Justyna Sawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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Tissue Organization by Cadherin Adhesion Molecules: Dynamic Molecular and Cellular Mechanisms of Morphogenetic Regulation

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Characterization of the Structure and Function of Escherichia coli DegQ as a Representative of the DegQ-like Proteases of Bacterial HtrA Family Proteins

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Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

Biochemical and functional characterization of Helicobacter pylori vesicles

(2010) Annelie Olofsson et al.   MOLECULAR MICROBIOLOGY

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues

(2010) Tobias Krojer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

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(2009) Q.-T. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2009) Hanne Ingmer et al.   RESEARCH IN MICROBIOLOGY

Role of type IV secretion inHelicobacter pyloripathogenesis

(2008) Steffen Backert et al.   CELLULAR MICROBIOLOGY

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(2008) Tobias Krojer et al.   NATURE

Prediction of Extracellular Proteases of the Human Pathogen Helicobacter pylori Reveals Proteolytic Activity of the Hp1018/19 Protein HtrA

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(2008) J. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA