Article
Obstetrics & Gynecology
Daphne Vassiliou, Angelica Linden Hirschberg, Eliane Sardh
Summary: Women with acute hepatic porphyria may undergo fertility treatments such as in vitro fertilization without experiencing severe attacks, but individual assessment of potential risks, close collaboration with a porphyria specialist, and regular monitoring of biochemical activity during ovarian stimulation are recommended. More studies are needed to assess the porphyrinogenicity of stimulation agents and shed light on the reproductive health of these women.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Pharmacology & Pharmacy
Sandra Hummelgaard, Joachim Pold Vilstrup, Camilla Gustafsen, Simon Glerup, Kathrin Weyer
Summary: Lowering blood cholesterol levels is crucial for reducing the risk of ASCVD, and PCSK9 plays a key role in cholesterol metabolism. Inhibiting PCSK9 has been shown to effectively reduce cholesterol levels and mitigate the risk of ASCVD events.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Pin-Hsuan Ke, Jau-Yuan Chen, Yi-Hsuan Chen, Wei-Chung Yeh, Wen-Cheng Li
Summary: This study investigated the correlation between cardiometabolic risk factors and Lp-PLA2 levels. It found that Lp-PLA2 was significantly related to lipoproteins and GPT, and its correlation with other factors such as fasting glucose, obesity-related parameters, and mean arterial pressure varied with age and sex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ziqing Wang, Jian Li
Summary: Developments in neoadjuvant and adjuvant chemotherapy have increased the number of breast cancer survivors. Determining appropriate follow-up care for these patients is crucial. Deaths from cardiovascular disease are significant in breast cancer patients. This review suggests that chemotherapeutic agents may impact lipoprotein(a) concentrations in breast cancer survivors after chemotherapy, potentially increasing cardiovascular disease risk. Further clinical trials are needed to establish a possible causal relationship. Existing and emerging therapies, such as hormone replacement therapy and statins, may lower Lp(a) concentrations and decrease the incidence of cardiovascular disease.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Sai Sahana Sundararaman, Yvonne Doring, Emiel P. C. van Der Vorst
Summary: PCSK9, primarily secreted by hepatocytes, plays a role in regulating the degradation of the LDL receptor. Its effects on cardiovascular complications are not only LDLR-related, but also involve other independent pathways and processes.
Article
Cardiac & Cardiovascular Systems
Wenfang Ma, Xiying Guo, Yiming Ma, Zhao Hu
Summary: PCSK9 mAbs effectively reduce the risk of MACEs, stroke, and myocardial infarction in patients at high cardiovascular risk compared to placebo. However, they are not superior to ezetimibe in preventing adverse cardiovascular events, highlighting the need for RCTs with long-term follow-up and cardiovascular events as the research endpoint.
Letter
Medicine, General & Internal
Donald M. Lyall, Joey Ward, Maciej Banach, George Davey Smith, Jason G. Gill, Jill P. Pell, Michael V. Holmes, Naveed Sattar
Summary: The study found an association between lower CHD risk and PCSK9 allele score, but also weakly linked it with worse reaction time, suggesting a potential relationship between PCSK9 genetic variants and cognitive function.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Enchen Zhou, Zhuang Li, Hiroyuki Nakashima, Ahlam Choukoud, Sander Kooijman, Jimmy F. P. Berbee, Patrick C. N. Rensen, Yanan Wang
Summary: Accelerating lipolytic processing of VLDL by brown fat activation can further lower (V)LDL levels and reduce the risk of atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Obstetrics & Gynecology
Guy Morris, Dimitrios Mavrelos, Rabi Odia, Xavier Vinals Gonzalez, Suzanne Cawood, Ephia Yasmin, Wael Saab, Paul Serhal, Srividya Seshadri
Summary: Studies have shown that paternal age has an impact on the outcomes of IVF/ICSI cycles, with older paternal age being associated with increased miscarriage rate and decreased live birth rate. However, paternal age over 50 is not independently associated with miscarriage risk following ART. It is important to communicate a public health message encouraging men not to delay fatherhood.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Obstetrics & Gynecology
Karoline Gundersen Sarmon, Troels Eliasen, Ulla Breth Knudsen, Bjorn Bay
Summary: The study identified an increased risk of stillbirth in pregnancies resulting from in vitro fertilization (IVF) and IVF with intracytoplasmic sperm injection (IVF-ICSI) compared to spontaneous conception, highlighting the potential risks associated with assisted reproductive technologies.
FERTILITY AND STERILITY
(2021)
Article
Cardiac & Cardiovascular Systems
Christie M. Ballantyne, Puja Banka, Gustavo Mendez, Raymundo Garcia, Julio Rosenstock, Anthony Rodgers, Geraldine Mendizabal, Yale Mitchel, Alberico L. Catapano
Summary: MK-0616, an oral PCSK9 inhibitor, effectively reduces LDL-C levels and is well tolerated in the treatment of hypercholesterolemia according to a Phase 2b clinical trial.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Victoria Nikitaras, Deirdre Zander-Fox, Nicole O. McPherson
Summary: Research shows that in vitro, the addition of idebenone can reduce ROS concentrations in sperm from older fathers, leading to improved fertilization rates, embryo quality, and implantation rates.
Article
Cardiac & Cardiovascular Systems
Csaba Matyas, Eszter Trojnar, Suxian Zhao, Muhammad Arif, Partha Mukhopadhyay, Attila Kovacs, Alexandra Fabian, Marton Tokodi, Zsolt Bagyura, Bela Merkely, Laszlo Kohidai, Eszter Lajko, Angela Takacs, Yong He, Bin Gao, Janos Paloczi, Falk W. Lohoff, Gyorgy Hasko, Wen-Xing Ding, Pal Pacher
Summary: This study found a positive correlation between PCSK9 and age-related CVD, and demonstrated that PCSK9 inhibition can effectively slow down the progression of CVD in aging rats.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Obstetrics & Gynecology
J. Barberet, C. Binquet, M. Guilleman, A. Doukani, C. Choux, C. Bruno, A. Bourredjem, C. Chapusot, D. Bourc'his, Y. Duffourd, P. Fauque
Summary: This study compared the epigenetic profiles of children conceived through ART and naturally conceived children, finding significant differences in DNA methylation levels of IGs between the two groups. While there were no differences found in the culture media, specific IG regions related to development showed methylation changes between children conceived through ART and naturally conceived children.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Maayan Hagbi Bal, Avi Harlev, Ruslan Sergienko, Eliahu Levitas, Iris Har-Vardi, Atif Zeadna, Aya Mark-Reich, Hadas Becker, Noa Ben-David, Lechaim Naggan, Tamar Wainstock
Summary: The study found an association between IVF treatment and offspring neoplasm risk, especially for offspring transferred as fresh embryos, at an earlier embryotic stage, or after harvesting three or more oocytes.
FERTILITY AND STERILITY
(2021)
Review
Pharmacology & Pharmacy
Konstantinos G. Kyriakoulis, Anastasios Kollias, Ioannis G. Kyriakoulis, Ioanna A. Kyprianou, Chrysso Papachrysostomou, Panagiotis Makaronis, Rafail A. Kotronias, Dimitrios Terentes-Printzios, Ioannis Toskas, Dimitri P. Mikhailidis
Summary: This study conducted a systematic review to analyze national and international guidelines on thromboprophylaxis strategies in COVID-19 patients. The key to thromboprophylaxis strategies lies in stratifying thrombotic and bleeding risks. The majority of guidelines recommend prophylactic dose of low molecular weight heparin for all hospitalized patients.
CURRENT VASCULAR PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Terentes-Printzios, Nikolaos Ioakeimidis, Konstantinos Rokkas, Charalambos Vlachopoulos
Summary: The translation discusses the importance of sexual health in overall health and well-being, focusing on the prevalence of sexual dysfunction, particularly erectile dysfunction (ED), in cardiovascular disease (CVD) patients. Shared risk factors and pathophysiological links between CVD and ED highlight the need for screening and diagnosing ED for preventive measures. This Review emphasizes the incorporation of sexual function into the patient history by physicians treating CVD patients to improve quality of life and cardiovascular outcomes.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Terentes-Printzios, Dimitrios Oikonomou, Konstantia-Paraskevi Gkini, Vasiliki Gardikioti, Konstantinos Aznaouridis, Ioanna Dima, Konstantinos Tsioufis, Charalambos Vlachopoulos
Summary: Coronary revascularization should be guided by the functional significance of coronary lesions. Fractional flow reserve (FFR) is the gold standard for assessing the hemodynamic importance of coronary stenosis, but its utilization in clinical practice is limited. In recent years, several methods of estimating FFR based on coronary angiography images have emerged, providing non-invasive alternatives to traditional FFR measurements.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Federico Marin, Roberto Scarsini, Dimitrios Terentes-Printzios, Rafail A. Kotronias, Flavio Ribichini, Adrian P. Banning, Giovanni Luigi De Maria
Summary: Invasive assessment of coronary physiology has greatly changed the approach to myocardial revascularization in patients with coronary artery disease. Available tools and techniques in the catheterization laboratory allow for a thorough evaluation of both epicardial and microvascular compartments of the coronary tree. The role of coronary microcirculation in regulating coronary flow and its implications in clinical and prognostic outcomes are increasingly recognized.
CURRENT CARDIOLOGY REVIEWS
(2022)
Article
Multidisciplinary Sciences
Giovanni Luigi De Maria, Luca Testa, Jose de la Torre Hernandez, Dimitrios Terentes-Printzios, Maria Emfietzoglou, Roberto Scarsini, Francesco Bedogni, Ernest Spitzer, Adrian Banning
Summary: The OPTIMAL trial aims to provide definitive evidence about the clinical impact of IVUS-guidance during PCI to an unprotected LMCA. It is anticipated that an IVUS-guided strategy will be associated with fewer clinical events compared to a strategy guided by angiogram alone.
Article
Peripheral Vascular Disease
Nikolaos Ioakeimidis, Ioanna Gourgouli, Dimitrios Terentes-Printzios, Danai-Magdalini Gourgouli, Christos Georgakopoulos, Konstantinos Aznaouridis, Sofia Spai, Dimitris Tousoulis, Konstantinos Tsioufis, Charalambos Vlachopoulos
Summary: Aortic stiffness and systemic inflammation are associated with response to anti-VEGF therapy, and intravitreal ranibizumab injections can lead to a decrease in aortic stiffness and serum high sensitivity interleukin-6 levels. Both parameters can predict clinical improvement.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Dimitrios Terentes-Printzios, Panagiotis Xydis, Ioanna Gourgouli, Konstantinos Tampakis, Sokratis Pastromas, Alexandros Sikiotis, Alexios Antonopoulos, George Andrikopoulos, Konstantinos Tsiou, Charalambos Vlachopoulos
HELLENIC JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Elisabetta Bianchini, Mai Tone Lonnebakken, Peter Wohlfahrt, Senol Piskin, Dimitrios Terentes-Printzios, Jordi Alastruey, Andrea Guala
Summary: Magnetic resonance imaging and computed tomography accurately assess arterial state and function, but the complexity and technical requirements of some biomarkers hinder their widespread use. This review summarizes current biomarkers related to aortic aging, their principles, required sequences and postprocessing, and their predictive values for cardiovascular events.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Pediatrics
Eleni Magdalini Kyritsi, Ioannis-Anargyros Vasilakis, Ioanna Kosteria, Aimilia Mantzou, Alexandros Gryparis, Eva Kassi, Gregory Kaltsas, Christina Kanaka-Gantenbein
Summary: This study investigated the frequency of autoimmune thyroiditis (AT) among euthyroid prepubertal girls with premature adrenarche (PA). The clinical, metabolic, and endocrine profiles of girls with concurrent AT and PA were compared to girls with AT without PA, PA alone, and healthy controls.
FRONTIERS IN PEDIATRICS
(2023)
Review
Peripheral Vascular Disease
Keeron Stone, Dave Veerasingam, Michelle L. Meyer, Kevin S. Heffernan, Simon Higgins, Rosa Maria Bruno, Celia Alvarez Bueno, Marcus Doeerr, Arno Schmidt-Trucksass, Dimitrios Terentes-Printzios, Julija Voicehovska, Rachel E. Climie, Chloe Park, Giacomo Pucci, Martin Bahls, Lee Stoner
Summary: This review critiques the literature on the clinical assessment and management of cardiovascular disease using brachial-ankle pulse wave velocity (baPWV). It discusses the measurement of baPWV, its differences from carotid-femoral pulse wave velocity, and its value as an independent vascular biomarker. The review also identifies the evidence supporting baPWV in terms of concept validation, prospective validation, incremental value, and clinical utility, as well as the areas where evidence is limited or lacking.
Meeting Abstract
Endocrinology & Metabolism
E. Vlachopapadopoulou, I Kosteria, E. Dikaiakou, S. Leka-Emiris, F. Athanasouli, G. Moschonis, S. Michalacos
ANNALS OF NUTRITION AND METABOLISM
(2022)
Meeting Abstract
Endocrinology & Metabolism
S. Leka-Emiri, E. Vlachopapadopoulou, E. Dikaiakou, F. Athanasouli, I Kosteria, C. Evangelopoulou, M. KafetziI, V Petrou, S. T. Michalacos
ANNALS OF NUTRITION AND METABOLISM
(2022)
Meeting Abstract
Endocrinology & Metabolism
Elpis Athina Vlachopapadopoulou, Eirini Dikaiakou, Ioanna Kosteria, Fani Athanasouli, Maria Kafetzi, Stefanos Michalacos
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Sofia Leka-Emiri, Ioanna Kosteria, Elpis Vlachopapadopoulou, Eirini Dikaiakoy, Catherine Evangelopoulou, Maria Kafetzi, Vasilios Petrou, Stefanos Michalacos
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Endocrinology & Metabolism
Nicolas Nicolaides, Manousos Makridakis, Rosa-Anna Kitani, Konstantina Letsou, Evangelia Kressou, Eleni Angelopoulou, Ioannis-Anargyros Vasilakis, Ioanna Kosteria, Aimilia Mantzou, Ioannis Papassotiriou, Liza Varvogli, Jerome Zoidakis, Christina Kanaka-Gantenbein
HORMONE RESEARCH IN PAEDIATRICS
(2022)
