Biological Rationale for Targeting MEK/ERK Pathways in Anti-Cancer Therapy and to Potentiate Tumour Responses to Radiation
出版年份 2019 全文链接
标题
Biological Rationale for Targeting MEK/ERK Pathways in Anti-Cancer Therapy and to Potentiate Tumour Responses to Radiation
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 10, Pages 2530
出版商
MDPI AG
发表日期
2019-05-24
DOI
10.3390/ijms20102530
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation
- (2019) Sejeong Shin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caveolin-1 enhances metastasis formation in a human model of embryonal rhabdomyosarcoma through Erk signaling cooperation
- (2019) Silvia Codenotti et al. CANCER LETTERS
- ERK Mutations and Amplification Confer Resistance to ERK-Inhibitor Therapy
- (2018) Bijay S. Jaiswal et al. CLINICAL CANCER RESEARCH
- Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo
- (2018) Carmela Ciccarelli et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
- (2018) Mark Merchant et al. PLoS One
- MEK inhibition induces MYOG and remodels super-enhancers in RAS-driven rhabdomyosarcoma
- (2018) Marielle E. Yohe et al. Science Translational Medicine
- A secondary mutation in BRAF confers resistance to RAF inhibition in a BRAF V600E-mutant brain tumor
- (2018) Jiawan Wang et al. Cancer Discovery
- Cancer stem cells: Road to therapeutic resistance and strategies to overcome resistance
- (2018) Monish Ram Makena et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- A compendium of ERK targets
- (2017) Evrim B. Ünal et al. FEBS LETTERS
- Pharmacological targeting of the ephrin receptor kinase signalling by GLPG1790 in vitro and in vivo reverts oncophenotype, induces myogenic differentiation and radiosensitizes embryonal rhabdomyosarcoma cells
- (2017) Francesca Megiorni et al. Journal of Hematology & Oncology
- Molecular testing for BRAF mutations to inform melanoma treatment decisions: a move toward precision medicine
- (2017) Liang Cheng et al. MODERN PATHOLOGY
- The molecular mechanisms of chemoresistance in cancers
- (2017) Hua-Chuan Zheng Oncotarget
- Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population
- (2016) Carmela Ciccarelli et al. Molecular Cancer
- Dissecting Therapeutic Resistance to ERK Inhibition
- (2016) S. Jha et al. MOLECULAR CANCER THERAPEUTICS
- A combinatorial strategy for treating KRAS-mutant lung cancer
- (2016) Eusebio Manchado et al. NATURE
- c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines
- (2016) G. L. Gravina et al. RADIATION RESEARCH
- Structural Basis for the Non-catalytic Functions of Protein Kinases
- (2016) Jennifer E. Kung et al. STRUCTURE
- Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer
- (2016) Mahmoud Toulany et al. Oncotarget
- Phenotypic Characterization of a Comprehensive Set of MAPK1 /ERK2 Missense Mutants
- (2016) Lisa Brenan et al. Cell Reports
- MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways
- (2015) Adriana Estrada-Bernal et al. CELL CYCLE
- ERK1/2 can feedback-regulate cellular MEK1/2 levels
- (2015) Seung-Keun Hong et al. CELLULAR SIGNALLING
- Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma
- (2015) Fiorella Faggi et al. LABORATORY INVESTIGATION
- Detailed imaging and genetic analysis reveal a secondaryBRAFL505Hresistance mutation and extensive intrapatient heterogeneity in metastaticBRAFmutant melanoma patients treated with vemurafenib
- (2015) Marlous Hoogstraat et al. Pigment Cell & Melanoma Research
- Trametinib radiosensitises RAS- and BRAF-mutated melanoma by perturbing cell cycle and inducing senescence
- (2015) Ulrike Schick et al. RADIOTHERAPY AND ONCOLOGY
- Cancer stem cells, cancer cell plasticity and radiation therapy
- (2015) Erina Vlashi et al. SEMINARS IN CANCER BIOLOGY
- Cancer stem cells and signaling pathways in radioresistance
- (2015) Lei Chang et al. Oncotarget
- Functional Redundancy of ERK1 and ERK2 MAP Kinases during Development
- (2015) Christophe Frémin et al. Cell Reports
- Signal Transduction in Cancer
- (2015) R. Sever et al. Cold Spring Harbor Perspectives in Medicine
- Vitamin D protects endothelial cells from irradiation-induced senescence and apoptosis by modulating MAPK/SirT1 axis
- (2015) F. Marampon et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- ERK Mutations Confer Resistance to Mitogen-Activated Protein Kinase Pathway Inhibitors
- (2014) E. M. Goetz et al. CANCER RESEARCH
- Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells
- (2014) L Kyjacova et al. CELL DEATH AND DIFFERENTIATION
- Metastatic Stem Cells: Sources, Niches, and Vital Pathways
- (2014) Thordur Oskarsson et al. Cell Stem Cell
- Hypoxia sustains glioblastoma radioresistance through ERKs/DNA-PKcs/HIF-1α functional interplay
- (2014) FRANCESCO MARAMPON et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma
- (2014) Jin Cheng et al. Molecular Oncology
- Discovery and saturation analysis of cancer genes across 21 tumour types
- (2014) Michael S. Lawrence et al. NATURE
- MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by 1-adrenergic receptors
- (2014) T. Ogata et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma
- (2014) Georgina V. Long et al. Nature Communications
- MYC Degradation
- (2014) A. S. Farrell et al. Cold Spring Harbor Perspectives in Medicine
- Ionizing Radiation-Induced DNA Damage, Response, and Repair
- (2013) Wil L. Santivasi et al. ANTIOXIDANTS & REDOX SIGNALING
- Close correlation between MEK/ERK and Aurora-B signaling pathways in sustaining tumorigenic potential and radioresistance of gynecological cancer cell lines
- (2013) FRANCESCO MARAMPON et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Genome-wide Kinase-Chromatin Interactions Reveal the Regulatory Network of ERK Signaling in Human Embryonic Stem Cells
- (2013) Jonathan Göke et al. MOLECULAR CELL
- Landscape of genomic alterations in cervical carcinomas
- (2013) Akinyemi I. Ojesina et al. NATURE
- Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers
- (2013) Georgia Hatzivassiliou et al. NATURE
- The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma
- (2013) E. M. Van Allen et al. Cancer Discovery
- Inhibition of ERK activation enhances the repair of double-stranded breaks via non-homologous end joining by increasing DNA-PKcs activation
- (2012) Fengxiang Wei et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Sorafenib potentiates irradiation effect in hepatocellular carcinoma in vitro and in vivo
- (2012) Wen Yu et al. CANCER LETTERS
- Cancer and Radiation Therapy: Current Advances and Future Directions
- (2012) Rajamanickam Baskar et al. International Journal of Medical Sciences
- Reactivation of Mitogen-activated Protein Kinase (MAPK) Pathway by FGF Receptor 3 (FGFR3)/Ras Mediates Resistance to Vemurafenib in Human B-RAF V600E Mutant Melanoma
- (2012) Vipin Yadav et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin- 2
- (2012) A. von Thun et al. JOURNAL OF CELL SCIENCE
- Specifically targeting ERK1 or ERK2 kills Melanoma cells
- (2012) Jianzhong Qin et al. Journal of Translational Medicine
- Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals
- (2012) John G. Albeck et al. MOLECULAR CELL
- ERK1/2 MAP kinases: Structure, function, and regulation
- (2012) Robert Roskoski PHARMACOLOGICAL RESEARCH
- Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy
- (2011) F. Wei et al. CURRENT MEDICINAL CHEMISTRY
- Factors determining DNA double-strand break repair pathway choice in G2 phase
- (2011) Atsushi Shibata et al. EMBO JOURNAL
- MEK/ERK Inhibitor U0126 Increases the Radiosensitivity of Rhabdomyosarcoma Cells In vitro and In vivo by Downregulating Growth and DNA Repair Signals
- (2011) F. Marampon et al. MOLECULAR CANCER THERAPEUTICS
- Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy
- (2011) Qian Huang et al. NATURE MEDICINE
- Amplification of the Driving Oncogene, KRAS or BRAF, Underpins Acquired Resistance to MEK1/2 Inhibitors in Colorectal Cancer Cells
- (2011) A. S. Little et al. Science Signaling
- Pathological roles of MAPK signaling pathways in human diseases
- (2010) Eun Kyung Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells
- (2010) Sarah E. Golding et al. CANCER BIOLOGY & THERAPY
- Acquired Resistance to BRAF Inhibitors Mediated by a RAF Kinase Switch in Melanoma Can Be Overcome by Cotargeting MEK and IGF-1R/PI3K
- (2010) Jessie Villanueva et al. CANCER CELL
- Both ERK1 and ERK2 kinases promote G2/M arrest in etoposide-treated MCF7 cells by facilitating ATM activation
- (2010) Fengxiang Wei et al. CELLULAR SIGNALLING
- ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma–lamin A complexes
- (2010) Javier Rodríguez et al. JOURNAL OF CELL BIOLOGY
- ERK2 but Not ERK1 Induces Epithelial-to-Mesenchymal Transformation via DEF Motif-Dependent Signaling Events
- (2010) Sejeong Shin et al. MOLECULAR CELL
- Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
- (2010) Gideon Bollag et al. NATURE
- BRAF Gene Amplification Can Promote Acquired Resistance to MEK Inhibitors in Cancer Cells Harboring the BRAF V600E Mutation
- (2010) R. B. Corcoran et al. Science Signaling
- Radiation Resistance of Cancer Stem Cells: The 4 R's of Radiobiology Revisited
- (2010) Frank Pajonk et al. STEM CELLS
- MEK–ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death
- (2010) A Tomiyama et al. Cell Death & Disease
- Next Generation DNA Sequencing and the Future of Genomic Medicine
- (2010) Matthew W. Anderson et al. Genes
- Massively Parallel Sequencing: The Next Big Thing in Genetic Medicine
- (2009) Tracy Tucker et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signaling
- (2009) Shaohui Hu et al. CELL
- Next-Generation Sequencing: From Basic Research to Diagnostics
- (2009) K. V. Voelkerding et al. CLINICAL CHEMISTRY
- Positive- and negative-feedback regulations coordinate the dynamic behavior of the Ras-Raf-MEK-ERK signal transduction pathway
- (2009) S.-Y. Shin et al. JOURNAL OF CELL SCIENCE
- Phosphoproteomics reveals new ERK MAP kinase targets and links ERK to nucleoporin-mediated nuclear transport
- (2009) Hidetaka Kosako et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- MEK1 mutations confer resistance to MEK and B-RAF inhibition
- (2009) C. M. Emery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes
- (2008) Jiahao Liu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells
- (2008) Joe W. Ramos INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Activation of Epidermal Growth Factor Receptor and Its Downstream Signaling Pathway by Nitric Oxide in Response to Ionizing Radiation
- (2008) H.-C. Lee et al. MOLECULAR CANCER RESEARCH
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now