期刊
ONCOTARGET
卷 7, 期 10, 页码 11002-11017出版社
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.6760
关键词
cancer; radiotherapy; radioresistance; CSC; signaling pathway
资金
- NHMRC [630664]
- Cancer Research Trust Fund (Cancer Care Centre, St George Hospital)
- Prostate and Breast Cancer Foundation (PBCF)
- China Scholarship Council
Radiation therapy (RT) is one of the most important strategies in cancer treatment. Radioresistance (the failure to RT) results in locoregional recurrence and metastasis. Therefore, it is critically important to investigate the mechanisms leading to cancer radioresistance to overcome this problem and increase patients' survival. Currently, the majority of the radioresistance-associated researches have focused on preclinical studies. Although the exact mechanisms of cancer radioresistance have not been fully uncovered, accumulating evidence supports that cancer stem cells (CSCs) and different signaling pathways play important roles in regulating radiation response and radioresistance. Therefore, targeting CSCs or signaling pathway proteins may hold promise for developing novel combination modalities and overcoming radioresistance. The present review focuses on the key evidence of CSC markers and several important signaling pathways in cancer radioresistance and explores innovative approaches for future radiation treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据