Article
Biochemistry & Molecular Biology
Elisa De Tomi, Rachele Campagnari, Elisa Orlandi, Alessia Cardile, Valentina Zanre, Marta Menegazzi, Macarena Gomez-Lira, Giovanni Gotte
Summary: ONC exhibits cytostatic and cytotoxic activities against melanoma by upregulating onco-suppressor microRNAs such as miR-20a-3p, miR-29a-3p, and miR-34a-5p. It also inhibits the expression of proteins involved in cell survival pathways and metastasis. These findings suggest that the anti-tumor effects of ONC in melanoma cells may be mediated by the regulation of miRNAs expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Gastroenterology & Hepatology
Feihong Deng, Jin Yan, Jiaxi Lu, Min Luo, Pianpian Xia, Siliang Liu, Xuehong Wang, Fachao Zhi, Deliang Liu
Summary: The study demonstrates that exosomal miR-590-3p derived from M2 macrophages promotes epithelial cell proliferation and wound healing by targeting LATS1 and activating YAP/beta-catenin-regulated transcription, while inhibiting inflammatory signals. This offers a new potential avenue for clinical therapy for ulcerative colitis.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Oncology
Yanjin Fu, Haiquan Liu, Mengsha Long, Linliang Song, Zuyu Meng, Shaozi Lin, Yiyao Zhang, JiaJia Qin
Summary: This study demonstrated for the first time that icariin significantly attenuated the growth of ovarian tumors and revealed that it suppresses tumor progression by upregulating miR-1-3p to inhibit TNKS2/Wnt/β-catenin signaling in ovarian cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Feng Zhou, Yu-Kai Wang, Cheng-Guo Zhang, Bing-Yi Wu
Summary: The study found that miR-19a/b-3p promotes inflammatory responses during cerebral ischemia/reperfusion injury by regulating the SIRT1/FoxO3/SPHK1 axis, providing a new therapeutic target for stroke treatment.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Endocrinology & Metabolism
John Garcia, Spenser S. Smith, Sangita Karki, Hicham Drissi, Henry H. Hrdlicka, Daniel W. Youngstrom, Anne M. Delany
Summary: miR-433-3p is a negative regulator of bone formation through various key signaling pathways such as PTH, MAPK, Wnt, and endogenous glucocorticoids, targeting multiple genes including Crebl, Hsd11b1, and Rspo3 to inhibit osteoblast activity and Wnt signaling pathway, reducing bone mass. In in vivo experiments, inhibitors of miR-433-3p can increase trabecular bone volume in mice, indicating its negative regulatory role in bone formation.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Environmental Sciences
Naresh Singh, Ekta Nagar, Anshu Gautam, Himanshi Kapoor, Naveen Arora
Summary: This study reveals that resveratrol stabilizes SIRT1 gene expression by inhibiting miR-212-3p, leading to downregulation of TGF-β and FoxO3a expressions in DE-induced pulmonary fibrosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Xiaoyuan Xu, Xiaohua Xu, Xiaoshuang Wang, Ling Shen
Summary: Baicalin has the potential to alleviate the symptoms of PCOS by regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axes.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Cell Biology
Zhongzhong Wan, Xingrun Li, Xinru Luo, Bofan Wang, Xiang Zhou, Ao Chen
Summary: CFHR3 plays a suppressive role in HCC cell proliferation and metastasis, with its downregulation associated with aggressive HCC and poor prognosis for patients. The downregulation of CFHR3 is induced by miR-590-3p binding and promotes STAT3 phosphorylation, leading to inhibition of p53 expression. Targeting the miR-590-3p/CFHR3/p-STAT3/p53 signaling axis may provide a promising therapeutic strategy for HCC.
Article
Biotechnology & Applied Microbiology
Li-Na You, Qin-Wen Tai, Lin Xu, Yi Hao, Wen-Jia Guo, Qiao Zhang, Qing Tong, Heng Zhang, Wu-Kui Huang
Summary: The study found that exosome-carried LINC00161 promotes HCC tumorigenesis by inhibiting miR-590-3p to activate the ROCK2 signaling pathway, suggesting that LINC00161 may be used as potential targets to improve HCC treatment efficiency.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Jiqiang Hu, Xuan Wang, Xiaoyun Cui, Wu Kuang, Dong Li, Jing Wang
Summary: This study investigated the mechanism of quercetin in atrial fibrillation-induced myocardial fibrosis, revealing that quercetin inhibits miR-223-3p and enhances FOXO3 expression, leading to increased autophagy and significant improvements in myocardial fibrosis and remodeling in atrial fibrillation.
Article
Oncology
Yingchun Zheng, Zhen Li, Shiying Yang, Yue Wang, Zhaohui Luan
Summary: circEXOC6B acts as an inhibitor in ovarian cancer, suppressing the progression and PTX resistance of ovarian cancer cells by sequestering miR-376c-3p and enhancing the level of FOXO3.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Oncology
Litao Yan, Gejun Liu, Xing Wu
Summary: This study found that exosomal lncRNA H19 derived from UMSCs acts as a competing endogenous RNA to enhance osteochondral activity in chondrocytes by sequestering miR-29b-3p. Injection of exosomes overexpressing H19 promoted sustained cartilage repair, highlighting its potential for developing strategies against cartilage defects.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Zhongyi Zhou, Fengbo Tan, Qian Pei, Chenglong Li, Yuan Zhou, Yuqiang Li, Haiping Pei
Summary: In colorectal cancer, SNHG4 modulates cell cycle regulation through the miR-590-3p/CDK1 pathway to influence cell proliferation and transplanted tumor growth. Further validation using additional animal models and clinical investigations is required for the application of this axis.
Article
Oncology
Alaa Ibrahem Youssef, Gehad Mahmoud Khaled, Asma Amleh
Summary: This study found that miR-590-3p is downregulated in hepatocellular carcinoma (HCC) and its forced expression can attenuate the proliferation and migration of HepG2 cells and repress the expression of EMT-related genes. The direct functional target of miR-590-3p is identified as MDM2, and the knockdown of MDM2 can mimic the inhibitory effect of miR-590-3p in HepG2 cells.