Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone

Cucurbitacin-B attenuates CCl4 -induced hepatic fibrosis in mice through inhibition of STAT-3

(2018) Alaliaa M. Sallam et al.   Chemical Biology & Drug Design

Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling

(2018) Kang-Hoon Kim et al.   Frontiers in Pharmacology

Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy

(2017) Yang Xiao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Antihypertensive drugs

(2017) Stéphane Laurent   PHARMACOLOGICAL RESEARCH

Oleanolic acid ameliorates high glucose-induced endothelial dysfunction via PPARδ activation

(2017) Zihui Zhang et al.   Scientific Reports

Diuretics for Hypertension: A Review and Update

(2016) George C. Roush et al.   AMERICAN JOURNAL OF HYPERTENSION

Cucurbitacin E ameliorates hepatic fibrosis in vivo and in vitro through activation of AMPK and blocking mTOR-dependent signaling pathway

(2016) Yan-Ling Wu et al.   TOXICOLOGY LETTERS

Anticancer effect of cucurbitacin B on MKN-45 cells via inhibition of the JAK2/STAT3 signaling pathway

(2016) You-Li Xie et al.   Experimental and Therapeutic Medicine

Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer

(2016) Mohammed Sikander et al.   Scientific Reports

Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis

(2016) Samriddhi Shukla et al.   Scientific Reports

Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity

(2015) Yuee Cai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis

(2015) S. Shukla et al.   Cancer Prevention Research

Clinical Significance of Endothelial Dysfunction in Essential Hypertension

(2015) Eugenia Gkaliagkousi et al.   CURRENT HYPERTENSION REPORTS

Cucurbitacin E, An Experimental Lead Triterpenoid with Anticancer, Immunomodulatory and Novel Effects Against Degenerative Diseases. A Mini-Review

(2015) Everaldo Attard et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Synergistic effect of cucurbitacin B in combination with curcumin via enhancing apoptosis induction and reversing multidrug resistance in human hepatoma cells

(2015) Yuqi Sun et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of blood pressure lowering on outcome incidence in hypertension

(2015) Costas Thomopoulos et al.   JOURNAL OF HYPERTENSION

Cucurbitacin D Is a Disruptor of the HSP90 Chaperone Machinery

(2015) Jessica A. Hall et al.   JOURNAL OF NATURAL PRODUCTS

Hypertension

(2015) Neil R Poulter et al.   LANCET

Cucurbitacin E Induces Autophagy via Downregulating mTORC1 Signaling and Upregulating AMPK Activity

(2015) Qing-Bing Zha et al.   PLoS One

Aging in blood vessels. Medicinal agents FOR systemic arterial hypertension in the elderly

(2014) María Esther Rubio-Ruiz et al.   AGEING RESEARCH REVIEWS

Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH-SY5Y human neuroblastoma cells

(2014) QIAN ZHENG et al.   Molecular Medicine Reports

Cardiovascular disease prevention

(2014) G. Van Camp   ACTA CLINICA BELGICA

The Effect of High Salt Intake on Endothelial Function: Reduced Vascular Nitric Oxide in the Absence of Hypertension

(2013) Matthew A. Boegehold   JOURNAL OF VASCULAR RESEARCH

Calcium Dynamics in Vascular Smooth Muscle

(2013) Gregory C. Amberg et al.   MICROCIRCULATION

The Effectiveness of Cucurbitacin B in BRCA1 Defective Breast Cancer Cells

(2013) Moltira Promkan et al.   PLoS One

Cucurbitacin B Induces Cell Cycle Arrest, Apoptosis and Autophagy Associated with G Actin Reduction and Persistent Activation of Cofilin in Jurkat Cells

(2012) Jun-Shan Zhu et al.   PHARMACOLOGY

The Role of Nitric Oxide on Endothelial Function

(2011) Dimitris Tousoulis et al.   Current Vascular Pharmacology

Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer

(2010) Gabriela B Iwanski et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway

(2010) Y. Dong et al.   CARCINOGENESIS

Issues in drug metabolism of major antihypertensive drugs: β-blockers, calcium channel antagonists and angiotensin receptor blockers

(2010) Christian Höcht et al.   Expert Opinion on Drug Metabolism & Toxicology

Mechanisms of hypertension in the cardiometabolic syndrome

(2009) Josep Redon et al.   JOURNAL OF HYPERTENSION