Yersinia pestis and plague: an updated view on evolution, virulence determinants, immune subversion, vaccination, and diagnostics

Yersinia pestis detection by loop-mediated isothermal amplification combined with magnetic bead capture of DNA

(2018) Na Feng et al.   BRAZILIAN JOURNAL OF MICROBIOLOGY

Plague: Bridging gaps towards better disease control

(2018) E. D’Ortenzio et al.   MEDECINE ET MALADIES INFECTIEUSES

Reemergence of human plague in Yunnan, China in 2016

(2018) Liyuan Shi et al.   PLoS One

Human ectoparasites and the spread of plague in Europe during the Second Pandemic

(2018) Katharine R. Dean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yersinia pestis Targets the Host Endosome Recycling Pathway during the Biogenesis of the Yersinia-Containing Vacuole To Avoid Killing by Macrophages

(2018) Michael G. Connor et al.   mBio

Analysis of 3800-year-old Yersinia pestis genomes suggests Bronze Age origin for bubonic plague

(2018) Maria A. Spyrou et al.   Nature Communications

Humoral and cellular immune responses to Yersinia pestis Pla antigen in humans immunized with live plague vaccine

(2018) Valentina A. Feodorova et al.   PLoS Neglected Tropical Diseases

Phylogeny and Classification of Yersinia pestis Through the Lens of Strains From the Plague Foci of Commonwealth of Independent States

(2018) Vladimir V. Kutyrev et al.   Frontiers in Microbiology

Ail provides multiple mechanisms of serum resistance to Yersinia pestis

(2018) Joshua J. Thomson et al.   MOLECULAR MICROBIOLOGY

Emergence and Spread of Basal Lineages of Yersinia pestis during the Neolithic Decline

(2018) Nicolás Rascovan et al.   CELL

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Visualization of translocons in Yersinia type III protein secretion machines during host cell infection

(2018) Theresa Nauth et al.   PLoS Pathogens

Enhanced Macrophage M1 Polarization and Resistance to Apoptosis Enable Resistance to Plague

(2017) Emilia Pachulec et al.   JOURNAL OF INFECTIOUS DISEASES

Zinc transporters YbtX and ZnuABC are required for the virulence of Yersinia pestis in bubonic and pneumonic plague in mice

(2017) Alexander G. Bobrov et al.   Metallomics

A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome

(2017) Andreas Diepold et al.   Nature Communications

Temporal phylogeography of Yersinia pestis in Madagascar: Insights into the long-term maintenance of plague

(2017) Amy J. Vogler et al.   PLoS Neglected Tropical Diseases

Host Iron Nutritional Immunity Induced by a Live Yersinia pestis Vaccine Strain Is Associated with Immediate Protection against Plague

(2017) Ayelet Zauberman et al.   Frontiers in Cellular and Infection Microbiology

Identification of New Virulence Factors and Vaccine Candidates for Yersinia pestis

(2017) Jourdan A. Andersson et al.   Frontiers in Cellular and Infection Microbiology

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Historical Y. pestis Genomes Reveal the European Black Death as the Source of Ancient and Modern Plague Pandemics

(2016) Maria A. Spyrou et al.   Cell Host & Microbe

Yersinia versus host immunity: how a pathogen evades or triggers a protective response

(2016) Lawton K Chung et al.   CURRENT OPINION IN MICROBIOLOGY

'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution

(2016) Alan McNally et al.   NATURE REVIEWS MICROBIOLOGY

A Deadly Path: Bacterial Spread During Bubonic Plague

(2016) Rodrigo J. Gonzalez et al.   TRENDS IN MICROBIOLOGY

Pneumonic Plague: The Darker Side of Yersinia pestis

(2016) Roger D. Pechous et al.   TRENDS IN MICROBIOLOGY

The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3

(2016) Congwen Wei et al.   Cell Death & Disease

Two Distinct Yersinia pestis Populations Causing Plague among Humans in the West Nile Region of Uganda

(2016) Laurel B. Respicio-Kingry et al.   PLoS Neglected Tropical Diseases

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells

(2016) Laura Berneking et al.   PLoS Pathogens

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

(2016) Naomi H. Philip et al.   PLoS Pathogens

Eighteenth century Yersinia pestis genomes reveal the long-term persistence of an historical plague focus

(2016) Kirsten I Bos et al.   eLife

Genotyping Yersinia pestis in Historical Plague: Evidence for Long-Term Persistence of Y. pestis in Europe from the 14th to the 17th Century

(2016) Lisa Seifert et al.   PLoS One

Early Divergent Strains of Yersinia pestis in Eurasia 5,000 Years Ago

(2015) Simon Rasmussen et al.   CELL

Inactivation of Peroxiredoxin 6 by the Pla Protease of Yersinia pestis

(2015) Daniel L. Zimbler et al.   INFECTION AND IMMUNITY

High-Throughput, Signature-Tagged Mutagenic Approach To Identify Novel Virulence Factors of Yersinia pestis CO92 in a Mouse Model of Infection

(2015) Duraisamy Ponnusamy et al.   INFECTION AND IMMUNITY

Monitoring biothreat agents (Francisella tularensis, Bacillus anthracis and Yersinia pestis) with a portable real-time PCR instrument

(2015) Markos Mölsä et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Climate-driven introduction of the Black Death and successive plague reintroductions into Europe

(2015) Boris V. Schmid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Transcriptional Profiling of Yersinia pestis Reveals a Novel Bacterial Mediator of Pulmonary Inflammation

(2015) Roger D. Pechous et al.   mBio

Spatially Distinct Neutrophil Responses within the Inflammatory Lesions of Pneumonic Plague

(2015) Nikolas M. Stasulli et al.   mBio

Complete Protection against Pneumonic and Bubonic Plague after a Single Oral Vaccination

(2015) Anne Derbise et al.   PLoS Neglected Tropical Diseases

Diverse Genotypes of Yersinia pestis Caused Plague in Madagascar in 2007

(2015) Julia M. Riehm et al.   PLoS Neglected Tropical Diseases

Circumventing Y. pestis Virulence by Early Recruitment of Neutrophils to the Lungs during Pneumonic Plague

(2015) Yaron Vagima et al.   PLoS Pathogens

Yersinia pestis Requires Host Rab1b for Survival in Macrophages

(2015) Michael G. Connor et al.   PLoS Pathogens

Dissemination of a Highly Virulent Pathogen: Tracking The Early Events That Define Infection

(2015) Rodrigo J. Gonzalez et al.   PLoS Pathogens

Yersinia pestis Activates Both IL-1β and IL-1 Receptor Antagonist to Modulate Lung Inflammation during Pneumonic Plague

(2015) Vijay Sivaraman et al.   PLoS Pathogens

Dermal Neutrophil, Macrophage and Dendritic Cell Responses to Yersinia pestis Transmitted by Fleas

(2015) Jeffrey G. Shannon et al.   PLoS Pathogens

Retracing the Evolutionary Path that Led to Flea-Borne Transmission of Yersinia pestis

(2014) Yi-Cheng Sun et al.   Cell Host & Microbe

Yersinia pestistargets neutrophils via complement receptor 3

(2014) Peter M. Merritt et al.   CELLULAR MICROBIOLOGY

S1P-Dependent Trafficking of Intracellular Yersinia pestis through Lymph Nodes Establishes Buboes and Systemic Infection

(2014) Ashley L. St. John et al.   IMMUNITY

Mechanical Homogenization Increases Bacterial Homogeneity in Sputum

(2014) J. R. Stokell et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Yersinia pestis Requires the 2-Component Regulatory System OmpR-EnvZ to Resist Innate Immunity During the Early and Late Stages of Plague

(2014) A. Reboul et al.   JOURNAL OF INFECTIOUS DISEASES

Yersinia pestis and the Plague of Justinian 541–543 AD: a genomic analysis

(2014) David M Wagner et al.   LANCET INFECTIOUS DISEASES

TheYersinia pestissiderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice

(2014) Alexander G. Bobrov et al.   MOLECULAR MICROBIOLOGY

Production of Outer Membrane Vesicles by the Plague Pathogen Yersinia pestis

(2014) Justin L. Eddy et al.   PLoS One

Silencing urease: A key evolutionary step that facilitated the adaptation ofYersinia pestisto the flea-borne transmission route

(2014) Iman Chouikha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Mutant Fitness Profiling Identifies Nutritional Requirements for Optimal Growth of Yersinia pestis in Deep Tissue

(2014) S. G. Palace et al.   mBio

New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague

(2014) Elizabeth Pradel et al.   PLoS Pathogens

IL-17A Produced by Neutrophils Protects against Pneumonic Plague through Orchestrating IFN- -Activated Macrophage Programming

(2013) Y. Bi et al.   JOURNAL OF IMMUNOLOGY

Inheritance of the Lysozyme Inhibitor Ivy Was an Important Evolutionary Step by Yersinia pestis to Avoid the Host Innate Immune Response

(2013) Anne Derbise et al.   JOURNAL OF INFECTIOUS DISEASES

Yersinia pestis survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages

(2013) Justin L. Spinner et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structural basis for the specific recognition of dual receptors by the homopolymeric pH 6 antigen (Psa) fimbriae of Yersinia pestis

(2013) R. Bao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Decade of Plague in Mahajanga, Madagascar: Insights into the Global Maritime Spread of Pandemic Plague

(2013) A. J. Vogler et al.   mBio

Yersinia pestis Subverts the Dermal Neutrophil Response in a Mouse Model of Bubonic Plague

(2013) J. G. Shannon et al.   mBio

Early Host Cell Targets of Yersinia pestis during Primary Pneumonic Plague

(2013) Roger D. Pechous et al.   PLoS Pathogens

Early Apoptosis of Macrophages Modulated by Injection of Yersinia pestis YopK Promotes Progression of Primary Pneumonic Plague

(2013) Kristen N. Peters et al.   PLoS Pathogens

Yersinia pestis DNA from Skeletal Remains from the 6th Century AD Reveals Insights into Justinianic Plague

(2013) Michaela Harbeck et al.   PLoS Pathogens

The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing

(2012) Christopher N. LaRock et al.   Cell Host & Microbe

Misidentification of Yersinia pestis by Automated Systems, Resulting in Delayed Diagnoses of Human Plague Infections--Oregon and New Mexico, 2010-2011

(2012) M. Tourdjman et al.   CLINICAL INFECTIOUS DISEASES

The Yfe and Feo Transporters Are Involved in Microaerobic Growth and Virulence of Yersinia pestis in Bubonic Plague

(2012) Jacqueline D. Fetherston et al.   INFECTION AND IMMUNITY

Deletion of the Braun Lipoprotein-Encoding Gene and Altering the Function of Lipopolysaccharide Attenuate the Plague Bacterium

(2012) Jian Sha et al.   INFECTION AND IMMUNITY

Nutritional immunity: transition metals at the pathogen–host interface

(2012) M. Indriati Hood et al.   NATURE REVIEWS MICROBIOLOGY

Pulmonary infection by Yersinia pestis rapidly establishes a permissive environment for microbial proliferation

(2012) P. A. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis

(2012) Y. Cui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YopK regulates the Yersinia pestis type III secretion system from within host cells

(2011) Rebecca Dewoody et al.   MOLECULAR MICROBIOLOGY

A draft genome of Yersinia pestis from victims of the Black Death

(2011) Kirsten I. Bos et al.   NATURE

Caspase 8 inhibits programmed necrosis by processing CYLD

(2011) Marie Anne O’Donnell et al.   NATURE CELL BIOLOGY

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System

(2010) Igor E. Brodsky et al.   Cell Host & Microbe

The Yersiniabactin Transport System Is Critical for the Pathogenesis of Bubonic and Pneumonic Plague

(2010) J. D. Fetherston et al.   INFECTION AND IMMUNITY

IL-17 Contributes to Cell-Mediated Defense against Pulmonary Yersinia pestis Infection

(2010) J.-S. Lin et al.   JOURNAL OF IMMUNOLOGY

Detection of Yersinia pestis using real-time PCR in patients with suspected bubonic plague

(2010) Julia M. Riehm et al.   MOLECULAR AND CELLULAR PROBES

Yersinia pestis genome sequencing identifies patterns of global phylogenetic diversity

(2010) Giovanna Morelli et al.   NATURE GENETICS

Distinct Clones of Yersinia pestis Caused the Black Death

(2010) Stephanie Haensch et al.   PLoS Pathogens

Real-time multiplex PCR assay for detection ofYersinia pestisandYersinia pseudotuberculosis

(2009) PIRJO MATERO et al.   APMIS

Yersinia pestis Can Reside in Autophagosomes and Avoid Xenophagy in Murine Macrophages by Preventing Vacuole Acidification

(2009) C. Pujol et al.   INFECTION AND IMMUNITY

Yersinia outer proteins: Yops

(2008) Jennifer E. Trosky et al.   CELLULAR MICROBIOLOGY

Current challenges in the development of vaccines for pneumonic plague

(2008) Stephen T Smiley   Expert Review of Vaccines

Immunization with Recombinant V10 Protects Cynomolgus Macaques from Lethal Pneumonic Plague

(2008) C. A. Cornelius et al.   INFECTION AND IMMUNITY

Braun Lipoprotein (Lpp) Contributes to Virulence of Yersiniae: Potential Role of Lpp in Inducing Bubonic and Pneumonic Plague

(2008) J. Sha et al.   INFECTION AND IMMUNITY

Plague: Past, Present, and Future

(2008) Nils Chr Stenseth et al.   PLOS MEDICINE

Crystal structure of the Yersinia pestis GTPase activator YopE

(2002) Artem G. Evdokimov et al.   PROTEIN SCIENCE