Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases

LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

(2019) Prabhjot Kaur et al.   Nature Communications

Targeting the messengers: Serine/threonine protein kinases as potential targets for antimycobacterial drug development

(2018) Mehak Zahoor Khan et al.   IUBMB LIFE

Serine/Threonine Protein Kinases from Bacteria, Archaea and Eukarya Share a Common Evolutionary Origin Deeply Rooted in the Tree of Life

(2018) Ivan Andreas Stancik et al.   JOURNAL OF MOLECULAR BIOLOGY

Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface

(2018) Xavier Carette et al.   mBio

Protein tyrosine kinase, PtkA, is required for Mycobacterium tuberculosis growth in macrophages

(2018) Dennis Wong et al.   Scientific Reports

Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments

(2018) Monika Janczarek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach

(2018) Magdalena Gil et al.   Journal of Proteomics

Two Faces of CwlM, an Essential PknB Substrate, in Mycobacterium tuberculosis

(2018) Obolbek Turapov et al.   Cell Reports

The crystal structure of PknI fromMycobacterium tuberculosisshows an inactive, pseudokinase-like conformation

(2017) María-Natalia Lisa et al.   FEBS Journal

The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus

(2017) Patrick Hardt et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Protein kinase G confers survival advantage toMycobacterium tuberculosisduring latency-like conditions

(2017) Mehak Zahoor Khan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain

(2017) Qiaoling Yan et al.   STRUCTURE

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis

(2017) Barbara Rieck et al.   PLoS Pathogens

PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae

(2017) Laure Zucchini et al.   Nature Microbiology

Structural and Genetic Analyses of theMycobacterium tuberculosisProtein Kinase B Sensor Domain Identify a Potential Ligand-binding Site

(2016) Daniil M. Prigozhin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative Unfolding of the Rubredoxin Domain and the Natively Disordered N-terminal Region Regulate the Catalytic Activity ofMycobacterium tuberculosisProtein Kinase G

(2016) Matthias Wittwer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis

(2016) Cara C Boutte et al.   eLife

Mass Spectrometry Offers Insight into the Role of Ser/Thr/Tyr Phosphorylation in the Mycobacteria

(2016) Bridget Calder et al.   Frontiers in Microbiology

Ser/Thr phosphorylation as a regulatory mechanism in bacteria

(2015) Jonathan Dworkin   CURRENT OPINION IN MICROBIOLOGY

Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic-type serine/threonine kinase fromMycobacterium tuberculosis

(2015) Sandeep K. Ravala et al.   FEBS Journal

Protein Kinase A (PknA) ofMycobacterium tuberculosisIs Independently Activated and Is Critical for Growthin Vitroand Survival of the Pathogen in the Host

(2015) Sathya Narayanan Nagarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphoproteomic analysis of bacillus Calmette–Guérin using gel-based and gel-free approaches

(2015) Jianhua Zheng et al.   Journal of Proteomics

The crystal structure of the catalytic domain of the ser/thr kinase PknA fromM. tuberculosisshows an Src-like autoinhibited conformation

(2015) Tristan Wagner et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular Basis of the Activity and the Regulation of the Eukaryotic-like S/T Protein Kinase PknG from Mycobacterium tuberculosis

(2015) María-Natalia Lisa et al.   STRUCTURE

Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria

(2015) Karen J. Kieser et al.   PLoS Pathogens

Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: expanding the mycobacterial phosphoproteome catalog

(2015) Suereta Fortuin et al.   Frontiers in Microbiology

Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens

(2015) David P Wright et al.   Virulence

Mycobacterium tuberculosis MtrB Sensor Kinase Interactions with FtsI and Wag31 Proteins Reveal a Role for MtrB Distinct from That Regulating MtrA Activities

(2014) R. Plocinska et al.   JOURNAL OF BACTERIOLOGY

Microbial Protein-tyrosine Kinases

(2014) Joseph D. Chao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Agents of change - concepts inMycobacterium tuberculosis Ser/Thr/Tyr phosphosignalling

(2014) David R. Sherman et al.   MOLECULAR MICROBIOLOGY

Mycobacterium tuberculosis supports protein tyrosine phosphorylation

(2014) U. Kusebauch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase)

(2013) Tristan Wagner et al.   BIOCHEMICAL JOURNAL

Analysis of SecA2-dependent substrates inMycobacterium marinumidentifies protein kinase G (PknG) as a virulence effector

(2013) Aniek D. van der Woude et al.   CELLULAR MICROBIOLOGY

Bacterial Cell Division Regulation by Ser/Thr Kinases: A Structural Perspective

(2013) Alessia Ruggiero et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Influence of Allosteric Regulators on Individual Steps in the Reaction Catalyzed byMycobacterium tuberculosis2-Hydroxy-3-oxoadipate Synthase

(2013) Anand Balakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of Phosphorylation Sites in the DivIVA Cytoskeletal Protein of Streptomyces coelicolor by Targeted LC–MS/MS

(2013) Gerhard Saalbach et al.   JOURNAL OF PROTEOME RESEARCH

Regulation of prokaryotic gene expression by eukaryotic-like enzymes

(2012) Kellie Burnside et al.   CURRENT OPINION IN MICROBIOLOGY

Mycobacterium tuberculosis CwsA Interacts with CrgA and Wag31, and the CrgA-CwsA Complex Is Involved in Peptidoglycan Synthesis and Cell Shape Determination

(2012) P. Plocinski et al.   JOURNAL OF BACTERIOLOGY

Structure of the Sensor Domain of Mycobacterium tuberculosis PknH Receptor Kinase Reveals a Conserved Binding Cleft

(2012) Alexandra Cavazos et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Analysis of Staphylococcus aureus Serine/Threonine Kinase PknB

(2012) Sonja Rakette et al.   PLoS One

The Ser/Thr protein kinase AfsK regulates polar growth and hyphal branching in the filamentous bacteria Streptomyces

(2012) A. M. Hempel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Phosphorylated Pseudokinase Complex Controls Cell Wall Synthesis in Mycobacteria

(2012) C. L. Gee et al.   Science Signaling

Regulation of Polar Peptidoglycan Biosynthesis by Wag31 Phosphorylation in Mycobacteria

(2011) Charul Jani et al.   BMC MICROBIOLOGY

Functional Plasticity and Allosteric Regulation of α-Ketoglutarate Decarboxylase in Central Mycobacterial Metabolism

(2011) Tristan Wagner et al.   CHEMISTRY & BIOLOGY

Chemical Basis of Peptidoglycan Discrimination by PrkC, a Key Kinase Involved in Bacterial Resuscitation from Dormancy

(2011) Flavia Squeglia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Eukaryote-Like Serine/Threonine Kinases and Phosphatases in Bacteria

(2011) S. F. F. Pereira et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Mutational dissection of the S/T-kinase StkP reveals crucial roles in cell division of Streptococcus pneumoniae

(2011) Aurore Fleurie et al.   MOLECULAR MICROBIOLOGY

Structural Insight into the Mycobacterium tuberculosis Rv0020c Protein and Its Interaction with the PknB Kinase

(2011) Christian Roumestand et al.   STRUCTURE

Signalling mechanisms in Mycobacteria

(2011) Pradip K. Chakraborti et al.   TUBERCULOSIS

The Extracytoplasmic Domain of the Mycobacterium tuberculosis Ser/Thr Kinase PknB Binds Specific Muropeptides and Is Required for PknB Localization

(2011) Mushtaq Mir et al.   PLoS Pathogens

Activity-Based Metabolomic Profiling of Enzymatic Function: Identification of Rv1248c as a Mycobacterial 2-Hydroxy-3-oxoadipate Synthase

(2010) Luiz Pedro S. de Carvalho et al.   CHEMISTRY & BIOLOGY

Identification of Multiple Substrates of the StkP Ser/Thr Protein Kinase in Streptococcus pneumoniae

(2010) L. Novakova et al.   JOURNAL OF BACTERIOLOGY

Division and cell envelope regulation by Ser/Thr phosphorylation:Mycobacteriumshows the way

(2010) Virginie Molle et al.   MOLECULAR MICROBIOLOGY

Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases

(2010) S. Prisic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric Activation Mechanism of the Mycobacterium tuberculosis Receptor Ser/Thr Protein Kinase, PknB

(2010) T. Noelle Lombana et al.   STRUCTURE

The Structure of PknB Extracellular PASTA Domain from Mycobacterium tuberculosis Suggests a Ligand-Dependent Kinase Activation

(2010) Philippe Barthe et al.   STRUCTURE

Protein kinase and phosphatase signaling in Mycobacterium tuberculosis physiology and pathogenesis

(2009) Joseph Chao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Signaling mechanisms of the Mycobacterium tuberculosis receptor Ser/Thr protein kinases

(2009) Tom Alber   CURRENT OPINION IN STRUCTURAL BIOLOGY

Key Residues inMycobacterium tuberculosisProtein Kinase G Play a Role in Regulating Kinase Activity and Survival in the Host

(2009) Divya Tiwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and biochemical analysis of the serine/threonine protein kinases PknA, PknB, PknG and PknL ofCorynebacterium glutamicum: evidence for non-essentiality and for phosphorylation of OdhI and FtsZ by multiple kinases

(2009) Christian Schultz et al.   MOLECULAR MICROBIOLOGY

An Intramolecular Switch Regulates Phosphoindependent FHA Domain Interactions in Mycobacterium tuberculosis

(2009) T. J. Nott et al.   Science Signaling

Dynamic and Structural Characterization of a Bacterial FHA Protein Reveals a New Autoinhibition Mechanism

(2009) Philippe Barthe et al.   STRUCTURE

A Eukaryotic-like Ser/Thr Kinase Signals Bacteria to Exit Dormancy in Response to Peptidoglycan Fragments

(2008) Ishita M. Shah et al.   CELL

The FHA-containing protein GarA acts as a phosphorylation-dependent molecular switch in mycobacterial signaling

(2008) Patrick England et al.   FEBS LETTERS

PknB-Mediated Phosphorylation of a Novel Substrate, N-Acetylglucosamine-1-Phosphate Uridyltransferase, Modulates Its Acetyltransferase Activity

(2008) Amit Parikh et al.   JOURNAL OF MOLECULAR BIOLOGY

Wag31, a homologue of the cell division protein DivIVA, regulates growth, morphology and polar cell wall synthesis in mycobacteria

(2008) C.-M. Kang et al.   MICROBIOLOGY-SGM

Regulation of glutamate metabolism by protein kinases in mycobacteria

(2008) Helen M. O'Hare et al.   MOLECULAR MICROBIOLOGY

TheMycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: Mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175c

(2008) Marc J. Canova et al.   PROTEOMICS

Structure and Function of the Phosphothreonine-Specific FHA Domain

(2008) A. Mahajan et al.   Science Signaling

Mycobacterial Ser/Thr protein kinases and phosphatases: Physiological roles and therapeutic potential

(2007) Annemarie Wehenkel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS