Article
Biochemistry & Molecular Biology
Shanshan Xu, Nan Wang, Dandan Yan, Yingjie Zhong
Summary: The study found that PE can alleviate asthma caused by obesity. In both mouse and cell experiments, PE can reduce airway inflammation and oxidative damage, as well as reduce body weight and inflammation levels in obese asthmatic mice.
MOLECULAR IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Miroslava Molitorisova, Martina Sutovska, Ivana Kazimierova, Jana Barborikova, Marta Joskova, Elena Novakova, Sona Franova
Summary: Kaempferol, a flavonol, demonstrated potential in modulating allergic airway inflammation and alleviating asthma features, such as airway hyperreactivity and cough reflex, in an experimental guinea pig model.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jack T. Womble, Mark D. Ihrie, Victoria L. McQuade, Akhil Hegde, Matthew S. McCravy, Sanat Phatak, Robert M. Tighe, Loretta G. Que, David D'Alessio, Julia K. L. Walker, Jennifer L. Ingram
Summary: Asthma is a chronic airway inflammatory disease, and patients with comorbid obesity may experience resistance to currently available therapeutics. Bariatric surgery has been shown to improve asthma control and airway hyperresponsiveness, but the underlying mechanisms are still unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mojdeh Matloubi, Latifa Koussih, Lianyu Shan, Chelsea Lukawy, Abdelilah S. Gounni
Summary: Asthma is a heterogeneous airway disease characterized by airway inflammation and remodeling, affecting more than 300 million people worldwide and posing a significant burden on society. Semaphorin3E, a critical molecule in lung pathophysiology, plays a role in both lung development and homeostasis. Recent studies have demonstrated that the Semaphorin3E-plexinD1 axis is implicated in asthma, impacting inflammatory and structural cells associated with airway inflammation, tissue remodeling, and airway hyperresponsiveness. This review highlights the potential role of the Semaphorin3E-plexinD1 axis as a therapeutic target in airway allergic diseases.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Jinmei Zhang, Zhengcan Wu, Fenfang Yu, Liang Ye, Wei Gu, Yan Tan, Li Wang, Ying Shi
Summary: The research found that LXRs can increase airway inflammation and hyperresponsiveness, as well as promote airway remodeling, suggesting that inhibiting LXRs may be a potential method for treating allergic asthma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Junjuan Wang, Ruolin Song, Ruoxi Lan, Mengzhen Hao, Guirong Liu, Manman Liu, Shanfeng Sun, Cheng Chen, Huilian Che
Summary: There is no universally accepted classification of the severity of allergic reactions triggered by different food allergens. A food allergy model was established to study the severity of allergies caused by peanut, egg, milk, and soybean proteins. It was found that peanut allergy was the most severe and soybean allergy was the least severe. Peanut allergy was associated with the regulation of asthma genes through the MAPK signaling pathway, leading to more severe allergic reactions.
Review
Allergy
Aaron D. Schwab, Jill A. Poole
Summary: Occupational lung disease, including asthma, is a significant cause of disability worldwide. While preventative considerations are important, there are currently no targeted medical therapies available to ameliorate lung injury post-exposure and prevent chronic airway disease development.
CURRENT ALLERGY AND ASTHMA REPORTS
(2023)
Article
Pharmacology & Pharmacy
Brandon W. Lewis, Maria L. Ford, Aiman Q. Khan, Joshua Walum, Rodney D. Britt
Summary: Type 2-high severe asthma is a distinct subtype characterized by Th2 inflammation, high eosinophil lung infiltration, impaired lung function, and reduced corticosteroid sensitivity. Acute and chronic allergen models induce type 2 inflammation, but the differences in corticosteroid sensitivity remain unclear. This study found that chronic allergen exposure is associated with more persistent type 2 immune responses and corticosteroid insensitivity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Efthymia Theofani, Georgina Xanthou
Summary: Autophagy is a crucial self-degradative process in cells that plays a key role in cellular renovation, physiology, and homeostasis. It can be triggered by factors such as starvation, pathogens, and stress, and is important in immune response regulation. Dysregulation of autophagy processes, either impaired or overactive, can contribute to the pathogenesis of various diseases, including infections and cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Takuma Okajima, Suguru Shigemori, Fu Namai, Tasuku Ogita, Takashi Sato, Takeshi Shimosato
Summary: The study found that prophylactic feeding of ODNcap can reduce allergic airway inflammation, hyperresponsiveness, and goblet cell hyperplasia in an ovalbumin-induced asthma model. Transcriptomics-driven approaches demonstrated that ODNcap feeding inhibits injury of pulmonary vein cardiomyocytes. Additionally, airway antimicrobial peptide and fecal microbiota participate in the ODNcap-mediated effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yunqin Shen, Lingjie Li, Wushi Chen, Qin Li, Yixuan Xu, Fang He, Caixia Wang, Zezhong Tian, Yanqiu Chen, Yan Yang
Summary: This study found that the deficiency of ApoE could aggravate airway inflammation and remodeling in mice with OVA-induced chronic asthma, suggesting that ApoE has a negative regulatory role in chronic asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chi-Chien Lin, Kai-Cheng Chuang, Shih-Wei Chen, Ya-Hsuan Chao, Chih-Ching Yen, Shang-Hsun Yang, Wei Chen, Kuang-Hsi Chang, Yu-Kang Chang, Chuan-Mu Chen
Summary: Lactoferrin exhibits anti-inflammation and immunoregulation activities in OVA-induced allergic asthma, ameliorating lung injury, decreasing Th2 cytokines and allergen-specific antibodies production, and influencing the functions of dendritic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Amlan Chakraborty, Anita A. Pinar, Maggie Lam, Jane E. Bourke, Simon G. Royce, Cordelia Selomulya, Chrishan S. Samuel
Summary: This study conjugated relaxin to nanoparticles and delivered them intranasally to a preclinical rodent model of chronic allergic airways disease and collagen gel contraction from asthma patient-derived myofibroblasts, showing potential anti-remodeling and anti-inflammatory effects, which could be important for treating the central features of asthma.
Article
Biochemistry & Molecular Biology
Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang, Jinhua Shen
Summary: PP121 exerts dual anti-contractile and anti-inflammatory effects in asthma treatment by blocking specific ion channels and downregulating inflammatory factors, mucins, and the MAPK/Akt signaling pathway in asthmatic mice, suggesting it as a promising therapeutic compound for asthma therapy.
MOLECULAR MEDICINE
(2023)
Article
Plant Sciences
Wen-Chung Huang, Tse-Hung Huang, Kuo-Wei Yeh, Ya-Ling Chen, Szu-Chuan Shen, Chian-Jiun Liou
Summary: The study showed that ginsenoside Rg3 significantly reduced airway inflammation, oxidative stress, and airway hyperresponsiveness in asthmatic mice, as well as decreased eosinophil infiltration. In tracheal epithelial cells, ginsenoside Rg3 also reduced inflammatory responses and oxidative stress.
JOURNAL OF GINSENG RESEARCH
(2021)