Animal NLRs provide structural insights into plant NLR function

Integrated decoys and effector traps: how to catch a plant pathogen

(2016) Jeffrey G. Ellis   BMC BIOLOGY

Comparative analysis of plant immune receptor architectures uncovers host proteins likely targeted by pathogens

(2016) Panagiotis F. Sarris et al.   BMC BIOLOGY

Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

(2016) Alan Merk et al.   CELL

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Integration of decoy domains derived from protein targets of pathogen effectors into plant immune receptors is widespread

(2016) Thomas Kroj et al.   NEW PHYTOLOGIST

Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium-based switch activation model

(2016) Maud Bernoux et al.   PLANT CELL

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryogenic Electron Microscopy and Single-Particle Analysis

(2015) Dominika Elmlund et al.   Annual Review of Biochemistry

Structural Biology of Innate Immunity

(2015) Qian Yin et al.   Annual Review of Immunology

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

A Receptor Pair with an Integrated Decoy Converts Pathogen Disabling of Transcription Factors to Immunity

(2015) Clémentine Le Roux et al.   CELL

A Plant Immune Receptor Detects Pathogen Effectors that Target WRKY Transcription Factors

(2015) Panagiotis F. Sarris et al.   CELL

The NLRP1 inflammasomes

(2015) Joseph Chavarría-Smith et al.   IMMUNOLOGICAL REVIEWS

The Tomato Nucleotide-binding Leucine-rich Repeat Immune Receptor I-2 Couples DNA-binding to Nucleotide-binding Domain Nucleotide Exchange

(2015) Stepan Fenyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments

(2015) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Potato Nucleotide-binding Leucine-rich Repeat (NLR) Immune Receptor Rx1 Is a Pathogen-dependent DNA-deforming Protein

(2015) Stepan Fenyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Random mutagenesis of the nucleotide-binding domain of NRC1 (NB-LRR Required for Hypersensitive Response-Associated Cell Death-1), a downstream signalling nucleotide-binding, leucine-rich repeat (NB-LRR) protein, identifies gain-of-function mutations in t

(2015) Daniela J. Sueldo et al.   NEW PHYTOLOGIST

Helper NLR proteins NRC2a/b and NRC3 but not NRC1 are required for Pto-mediated cell death and resistance inNicotiana benthamiana

(2015) Chih-Hang Wu et al.   NEW PHYTOLOGIST

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

2.2 A resolution cryo-EM structure of  -galactosidase in complex with a cell-permeant inhibitor

(2015) A. Bartesaghi et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation

(2015) Christoph A. Diebolder et al.   STRUCTURE

Molecular and Functional Analyses of a Maize Autoactive NB-LRR Protein Identify Precise Structural Requirements for Activity

(2015) Guan-Feng Wang et al.   PLoS Pathogens

Structural basis of pathogen recognition by an integrated HMA domain in a plant NLR immune receptor

(2015) A Maqbool et al.   eLife

The “sensor domains” of plant NLR proteins: more than decoys?

(2015) Chih-Hang Wu et al.   Frontiers in Plant Science

Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins

(2015) Justin A. MacDonald et al.   IUBMB LIFE

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

(2014) Thomas Ve et al.   APOPTOSIS

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

The NB‐LRR proteins RGA4 and RGA5 interact functionally and physically to confer disease resistance

(2014) Stella Césari et al.   EMBO JOURNAL

Diversity and Variability of NOD-Like Receptors in Fungi

(2014) Witold Dyrka et al.   Genome Biology and Evolution

Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I

(2014) Bin Wu et al.   MOLECULAR CELL

Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

(2014) S. J. Williams et al.   SCIENCE

Common mechanisms activate plant guard receptors and TLR4

(2014) Jonathan C. Kagan   TRENDS IN IMMUNOLOGY

A novel conserved mechanism for plant NLR protein pairs: the “integrated decoy” hypothesis

(2014) Stella Cesari et al.   Frontiers in Plant Science

Higher-Order Assemblies in a New Paradigm of Signal Transduction

(2013) Hao Wu   CELL

Structural Basis for the Interaction between the Potato Virus X Resistance Protein (Rx) and Its Cofactor Ran GTPase-activating Protein 2 (RanGAP2)

(2013) Wei Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Characterization of Sponge NLRs Provides Insight into the Origin and Evolution of This Innate Immune Gene Family in Animals

(2013) Benedict Yuen et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

The Rice Resistance Protein Pair RGA4/RGA5 Recognizes the Magnaporthe oryzae Effectors AVR-Pia and AVR1-CO39 by Direct Binding

(2013) S. Cesari et al.   PLANT CELL

Structural Determinants at the Interface of the ARC2 and Leucine-Rich Repeat Domains Control the Activation of the Plant Immune Receptors Rx1 and Gpa2

(2013) E. J. Slootweg et al.   PLANT PHYSIOLOGY

Structures of the flax-rust effector AvrM reveal insights into the molecular basis of plant-cell entry and effector-triggered immunity

(2013) T. Ve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of NLRC4 Reveals Its Autoinhibition Mechanism

(2013) Z. Hu et al.   SCIENCE

The CARD plays a critical role in ASC foci formation and inflammasome signalling

(2012) Martina Proell et al.   BIOCHEMICAL JOURNAL

A new eye on NLR proteins: focused on clarity or diffused by complexity?

(2012) Vera Bonardi et al.   CURRENT OPINION IN IMMUNOLOGY

Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin

(2012) Els F. Halff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Analysis of the Coiled-Coil and Leucine-Rich Repeat Domains of the RPS5 Disease Resistance Protein

(2012) D. Qi et al.   PLANT PHYSIOLOGY

Structure-Function Analysis of Barley NLR Immune Receptor MLA10 Reveals Its Cell Compartment Specific Activity in Cell Death and Disease Resistance

(2012) Shiwei Bai et al.   PLoS Pathogens

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Coiled-Coil Domain-Dependent Homodimerization of Intracellular Barley Immune Receptors Defines a Minimal Functional Module for Triggering Cell Death

(2011) Takaki Maekawa et al.   Cell Host & Microbe

New insights in plant immunity signaling activation

(2011) Maud Bernoux et al.   CURRENT OPINION IN PLANT BIOLOGY

A Nucleotide Phosphatase Activity in the Nucleotide Binding Domain of an Orphan Resistance Protein from Rice

(2011) Stepan Fenyk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Autoactive Mutant of the M Flax Rust Resistance Protein Has a Preference for Binding ATP, Whereas Wild-Type M Protein Binds ADP

(2011) Simon J. Williams et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Cell Death Mediated by the N-Terminal Domains of a Unique and Highly Conserved Class of NB-LRR Protein

(2011) Sarah M. Collier et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

(2011) Eric M. Kofoed et al.   NATURE

NLR functions in plant and animal immune systems: so far and yet so close

(2011) Takaki Maekawa et al.   NATURE IMMUNOLOGY

Tracing the origin and evolutionary history of plant nucleotide-binding site-leucine-rich repeat (NBS-LRR) genes

(2011) Jia-Xing Yue et al.   NEW PHYTOLOGIST

A multifaceted genomics approach allows the isolation of the rice Pia-blast resistance gene consisting of two adjacent NBS-LRR protein genes

(2011) Yudai Okuyama et al.   PLANT JOURNAL

Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors

(2011) V. Bonardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of Full-Length Apaf-1: How the Death Signal Is Relayed in the Mitochondrial Pathway of Apoptosis

(2011) Thomas Frank Reubold et al.   STRUCTURE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Crystal Structure of the Caenorhabditis elegans Apoptosome Reveals an Octameric Assembly of CED-4

(2010) Shiqian Qi et al.   CELL

Plant immunity: towards an integrated view of plant–pathogen interactions

(2010) Peter N. Dodds et al.   NATURE REVIEWS GENETICS

Activation of an Arabidopsis Resistance Protein Is Specified by the in Planta Association of Its Leucine-Rich Repeat Domain with the Cognate Oomycete Effector

(2010) K. V. Krasileva et al.   PLANT CELL

Arabidopsis and the plant immune system

(2010) Marc T. Nishimura et al.   PLANT JOURNAL

Innate instruction of adaptive immunity revisited: the inflammasome

(2009) Stephanie C. Eisenbarth et al.   EMBO Molecular Medicine

The TIR Domain of TIR-NB-LRR Resistance Proteins Is a Signaling Domain Involved in Cell Death Induction

(2009) Michal R. Swiderski et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The AvrM Effector from Flax Rust Has a Structured C-Terminal Domain and Interacts Directly with the M Resistance Protein

(2009) Ann-Maree Catanzariti et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

(2009) Olaf Gross et al.   NATURE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens

(2009) Igor E. Brodsky et al.   SEMINARS IN IMMUNOLOGY

Wheel of Life, Wheel of Death: A Mechanistic Insight into Signaling by STAND Proteins

(2009) Olivier Danot et al.   STRUCTURE

The NLR Gene Family: A Standard Nomenclature

(2008) Jenny P.-Y. Ting et al.   IMMUNITY

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Transcomplementation, but not Physical Association of the CC-NB-ARC and LRR Domains of Tomato R Protein Mi-1.2 is Altered by Mutations in the ARC2 Subdomain

(2008) Gerben van Ooijen et al.   Molecular Plant

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

(2008) Karla L Lightfield et al.   NATURE IMMUNOLOGY

From Guard to Decoy: A New Model for Perception of Plant Pathogen Effectors

(2008) R. A.L. van der Hoorn et al.   PLANT CELL

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

(2008) S. L. Fink et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA