Article
Chemistry, Physical
Michiel Sprik
Summary: Using diffusion coupled deformation theory, this study investigates how the elastic properties of a solid body are altered when maintaining chemomechanical equilibrium with a melt. The results indicate that enforcing chemomechanical equilibrium with the liquid reservoir reduces the bulk modulus of the solid to zero while the shear modulus remains finite. Additionally, the density dependence of the shear modulus is found to be a second order effect reducing the density of the stressed solid.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Engineering, Biomedical
Manuel Rausch, William D. D. Meador, John Toaquiza-Tubon, Omar Moreno-Flores, Adrian Buganza Tepole
Summary: Understanding the response of skin to superphysiological temperatures is crucial for the diagnosis, prognosis, and development of thermal therapies. This study explores the complex interdependence of time, temperature, direction, and load in skin's response to superphysiological temperatures. Two models are proposed to explain the observations, both based on the denaturation of the collagen microstructure. The success of these models provides guidance for future experiments and the engineering design of heat treatment therapies.
ACTA BIOMATERIALIA
(2022)
Article
Orthopedics
Chengjun Li, Tian Qin, Yuxin Jin, Jianzhong Hu, Feifei Yuan, Yong Cao, Chunyue Duan
Summary: This study found that cerebrospinal fluid-derived extracellular vesicles (CSF-EVs) can promote vascular regeneration and improve motor function recovery after spinal cord injury (SCI) by activating the PI3K/AKT pathway. This provides a potential novel therapeutic approach for the treatment of acute SCI.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Review
Chemistry, Physical
Mirza Baig, Josiah Owusu-Danquah, Anne A. Campbell, Stephen F. Duffy
Summary: This article provides a comprehensive review of the development of inelastic constitutive modeling in polycrystalline materials. It explores different models that account for nonlinear behavior at the microstructural level, including classic plasticity models and unified models. The article emphasizes the theoretical framework of unified viscoplasticity models and highlights the advantages of this approach in improving material modeling. It also discusses recent topics in constitutive modeling that bridge the gap between microstructure and continuum.
Article
Biotechnology & Applied Microbiology
Yuqing Xia, Pahala G. Jayathilake, Bowen Li, Paolo Zuliani, David Deehan, Jennifer Longyear, Paul Stoodley, Jinju Chen
Summary: Understanding the mechanical properties and detachment mechanisms of bacterial biofilms is crucial for determining their stability and removal. The study of biofilm mechanics can provide insights into biofilm survival under shear stress and inform strategies for biofilm removal.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Article
Engineering, Civil
Shijie Xie, Zhenyu Han, Yifan Chen, Yixian Wang, Yanlin Zhao, Hang Lin
Summary: This paper proposes a piecewise constitutive model for rock materials, which can reflect the complete stress-strain curves of rocks including the compaction stage, the elastic stage, the plastic yield stage and the post-peak stage. By analyzing the relationship between the strain of rock materials and the strains of voids and rock matrix, a corresponding constitutive model was established, and a damage statistical constitutive model of rocks was also developed using the modified Weibull distribution to describe the nonlinear deformation after the yield point.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2022)
Article
Cell Biology
Pedro Barbacena, Maria Dominguez-Cejudo, Catarina G. Fonseca, Manuel Gomez-Gonzalez, Laura M. Faure, Georgia Zarkada, Andreia Pena, Anna Pezzarossa, Daniela Ramalho, Ylenia Giarratano, Marie Ouarne, David Barata, Isabela C. Fortunato, Lenka Henao Misikova, Ian Mauldin, Yulia Carvalho, Xavier Trepat, Pere Roca-Cusachs, Anne Eichmann, Miguel O. Bernabeu, Claudio A. Franco
Summary: The competition between biochemical and mechanical signals controls the polarity shift of endothelial cells during blood-vessel formation, leading to tissue-level emergent behaviors and unique vascular patterns in each individual.
DEVELOPMENTAL CELL
(2022)
Article
Physics, Fluids & Plasmas
E. Sabri, C. Brosseau
Summary: This study utilizes a continuum-based analysis to model electrodeformation in cells suspended in a fluid medium and deformed with a controlled alternating electric field. It explores the impact of electric field anisotropy and electrical conductivity ratio on the stress exerted on cells, finding that modulation of electrical cues by the frequency of the electric field can manipulate cells effectively. The research also suggests that proximity-induced capacitive coupling and spatial anisotropy are crucial factors to consider in engineering the functional performance of cell assemblies.
Article
Biophysics
Nicholas Filla, Yiping Zhao, Xianqiao Wang
Summary: In this paper, a phenomenological, bilinear, force-strain model is derived to accurately reproduce the fibrin fiber force-strain curve. The model assumes that the initial linear response is due to entropic extension of polypeptide chains, and the final linear response is due to enthalpic extension of protofibrils. The model provides strong support to a previously proposed deformation mechanism and offers a rigorous tool for analyzing fibrin fiber force-strain data and simulating fibrin fibers in tension.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2023)
Review
Materials Science, Biomaterials
Jianxiong Xu, Jinxuan Wang, Yidan Chen, Yuanfang Hou, Jianjun Hu, Guixue Wang
Summary: This article discusses the progression of cardiovascular diseases such as atherosclerosis and myocardial infarction, emphasizing the role of extracellular vesicles (EVs) and the advancements of bioengineered EVs in biomedical applications for targeted regenerative therapy.
REGENERATIVE BIOMATERIALS
(2022)
Review
Immunology
Marie Robert, Pierre Miossec, Arnaud Hot
Summary: The involvement of IL-17A in autoimmune and inflammatory diseases has led to research on therapeutic strategies to block the Th17 pathway. IL-17A plays a positive role in inflammation, coagulation, thrombosis, and cardiovascular events, while its involvement in allograft rejection and vasculitis has been confirmed. Anti-IL-17 therapy may be a promising strategy for vasculitis treatment, but lessons from rheumatoid arthritis and multiple sclerosis need to be learned.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Physical
Ameya Rege
Summary: This paper investigates the macroscopic mechanical behavior of open-porous cellular materials and presents a constitutive model that captures the linear elastic, pore-collapse, and densification hardening. Through parameter sensitivity analysis and experimental validation against two types of nanoporous materials, the model's capability to capture different material characteristics is demonstrated.
Article
Engineering, Multidisciplinary
R. Ibanez, D. H. Kelley
Summary: This study presents a novel bioinspired experimental apparatus for studying peristaltic flows. The apparatus offers a wider range of modeling capabilities compared to previous designs and is particularly useful for systems with complex waveforms. The capabilities of the apparatus are validated through comparisons with analytic results, demonstrating its usefulness for biophysical studies.
BIOINSPIRATION & BIOMIMETICS
(2022)
Article
Materials Science, Multidisciplinary
Nicholas Filla, Jixin Hou, He Li, Xianqiao Wang
Summary: Fibrin fibers and fibrin network are crucial for blood clot functionality, but there is a lack of quantitative methods to understand how alterations in the microstructure of fibrin network affect its mechanical responses. This study presents a multiscale framework for modeling fibrin fibers and network, providing valuable insights into the mechanism underlying thromboembolism.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Article
Engineering, Biomedical
Ge He, Bing Xia, Yuan Feng, Yu Chen, Lei Fan, Dongsheng Zhang
Summary: This study extends the existing transversely isotropic hyperelastic model for white matter by coupling it with damage equations within the framework of thermodynamics and using continuum damage mechanics method. The proposed model is capable of capturing the damage-induced softening behaviors of white matter under large strain and investigates the effect of fiber orientation on these behaviors and material stiffness.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Cell Biology
David H. Jang, John C. Greenwood, Shawn Owiredu, Abhay Ranganathan, David M. Eckmann
Editorial Material
Cardiac & Cardiovascular Systems
Natalia Trayanova
NATURE REVIEWS CARDIOLOGY
(2019)
Article
Computer Science, Artificial Intelligence
Caroline H. Roney, Ali Pashaei, Marianna Meo, Remi Dubois, Patrick M. Boyle, Natalia A. Trayanova, Hubert Cochet, Steven A. Niederer, Edward J. Vigmond
MEDICAL IMAGE ANALYSIS
(2019)
Article
Cell Biology
Shawn Owiredu, Abhay Ranganathan, David M. Eckmann, Frances S. Shofer, Kevin Hardy, David S. Lambert, Matthew Kelly, David H. Jang
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2020)
Article
Cell Biology
Abhay Ranganathan, Shawn Owiredu, David H. Jang, David M. Eckmann
Review
Biochemistry & Molecular Biology
David M. Eckmann, Ryan P. Bradley, Sreeja K. Kandy, Keshav Patil, Paul A. Janmey, Ravi Radhakrishnan
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2020)
Article
Anesthesiology
Carlo Pancaro, Jasmine Purtell, Dana LaBuda, Leif Saager, Thomas T. Klumpner, Timur Dubovoy, Baskar Rajala, Shubhangi Singh, Ruth Cassidy, Christie Vahabzadeh, Sean Maxwell, Virgil Manica, David M. Eckmann, Jill M. Mhyre, Milo C. Engoren
Summary: The study demonstrated that the multiorifice wire-reinforced polyamide nylon blend epidural catheter had a higher rate of successful first attempt insertion compared to the single-end hole wire-reinforced polyurethane catheter for labor analgesia. The engineering properties of the equipment used, such as bending stiffness and angle formed by the needle and catheter, also played a critical role in determining the successful establishment of labor epidural analgesia.
ANESTHESIA AND ANALGESIA
(2021)
Article
Thermodynamics
David M. Eckmann, Jie Zhang, Portonovo S. Ayyaswamy
Summary: Vascular gas embolism is pervasive in medicine, causing various undesired biological reactions. Surfactant therapy, based on fluid dynamics, is a potential preventative approach to reduce tissue injury.
JOURNAL OF HEAT TRANSFER-TRANSACTIONS OF THE ASME
(2021)
Article
Chemistry, Multidisciplinary
Samaneh Farokhirad, Sreeja Kutti Kandy, Andrew Tsourkas, Portonovo S. Ayyaswamy, David M. Eckmann, Ravi Radhakrishnan
Summary: This study investigates how the mechanical properties of nanoparticles impact multivalent ligand-receptor-mediated binding to cell surfaces, as well as other related factors. The results show that the stiffness, flexibility, and membrane surface crowding of nanoparticles can affect the efficiency of cellular uptake of targeted nanoparticles.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Biology
Monika Colombo, Anna Corti, Diego Gallo, Andrea Colombo, Giacomo Antognoli, Martina Bernini, Ciara McKenna, Scott Berceli, Ted Vaughan, Francesco Migliavacca, Claudio Chiastra
Summary: This study analyzed the impact of stent design and stent overlapping on patient-specific SFA hemodynamics. The results showed that different stent designs and overlapping configurations significantly altered the hemodynamic parameters. Stent design type and overlapping length had a significant impact on the hemodynamics.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Jose A. Rosado-Toro, Rohit C. Philip, Samuel Thomas Dunn, Diego Celdran-Bonafonte, Yong He, Scott A. Berceli, Prabir Roy-Chaudhury, Eleonora Tubaldi
Summary: A software protocol for the functional analysis of arteriovenous fistula (AVF) has been developed, which utilizes anatomical analysis and magnetic resonance imaging (MRI) to better understand and predict the causes of AVF maturation failure, providing individualized treatment options for dialysis vascular access.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Biology
Anna Corti, Monika Colombo, Francesco Migliavacca, Scott A. Berceli, Stefano Casarin, Jose F. Rodriguez Matas, Claudio Chiastra
Summary: A multiscale agent-based modeling framework was proposed in this study to simulate the arterial wall remodeling after percutaneous transluminal angioplasty (PTA). The framework was able to accurately capture the changes in the arterial wall after 3 months of PTA, including the impact of damage and altered hemodynamics on arterial wall remodeling.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Anna Corti, Francesco Migliavacca, Scott A. Berceli, Claudio Chiastra
Summary: This study investigates the long-term arterial wall remodelling one year post-operation in stented superficial femoral arteries (SFAs) using multiscale computational agent-based modelling. The model successfully captures the initial reduction in lumen area and subsequent stabilization of lumen area, demonstrating the potential of this approach for studying patient-specific responses to endovascular interventions.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Toxicology
Shawn Owiredu, Abhay Ranganathan, John C. Greenwood, Sarah Piel, Joanna I. Janowska, David M. Eckmann, Matthew Kelly, Johannes K. Ehinger, Todd J. Kilbaugh, David H. Jang
TOXICOLOGY REPORTS
(2020)
Article
Chemistry, Multidisciplinary
Samaneh Farokhirad, Abhay Ranganathan, Jacob Myerson, Vladimir R. Muzykantov, Portonovo S. Ayyaswamy, David M. Eckmann, Ravi Radhakrishnan