Intracellular pH dynamics and charge-changing somatic mutations in cancer

Physicochemical amino acid properties better describe substitution rates in large populations

(2019) Claudia C Weber et al.   MOLECULAR BIOLOGY AND EVOLUTION

β-Catenin is a pH sensor with decreased stability at higher intracellular pH

(2018) Katharine A. White et al.   JOURNAL OF CELL BIOLOGY

ACVR1R206H FOP mutation alters mechanosensing and tissue stiffness during heterotopic ossification

(2018) Julia Haupt et al.   MOLECULAR BIOLOGY OF THE CELL

Cancer cell behaviors mediated by dysregulated pH dynamics at a glance

(2017) Katharine A. White et al.   JOURNAL OF CELL SCIENCE

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins

(2017) Katharine A. White et al.   Science Signaling

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1

(2017) Yvonne Vercoulen et al.   eLife

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins

(2017) Katharine A. White et al.   Science Signaling

Prominent features of the amino acid mutation landscape in cancer

(2017) Zachary A. Szpiech et al.   PLoS One

Exploring preferred amino acid mutations in cancer genes: Applications to identify potential drug targets

(2016) P. Anoosha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

(2016) Yasmine A. Valentin-Vega et al.   Scientific Reports

Lipid Binding Defects and Perturbed Synaptogenic Activity of a Collybistin R290H Mutant That Causes Epilepsy and Intellectual Disability

(2015) Theofilos Papadopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3

(2015) Stephen N. Floor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACVR1 R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A

(2015) Sarah J. Hatsell et al.   Science Translational Medicine

Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity

(2015) Hua Tan et al.   Scientific Reports

Increased H+ efflux is sufficient to induce dysplasia and necessary for viability with oncogene expression

(2015) Bree K Grillo-Hill et al.   eLife

Epigenetic Therapy for Solid Tumors: Highlighting the Impact of Tumor Hypoxia

(2015) Shaliny Ramachandran et al.   Genes

Structural basis of nSH2 regulation and lipid binding in PI3Kα

(2015) Michelle S. Miller et al.   Oncotarget

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

(2014) Pawel Buczkowicz et al.   NATURE GENETICS

Ion Channels and Transporters in Cancer: Pathophysiology, Regulation, and Clinical Potential

(2013) S. F. Pedersen et al.   CANCER RESEARCH

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

SMAD4 Genetic Alterations Predict a Worse Prognosis in Patients With Pancreatic Ductal Adenocarcinoma

(2012) Puneet Singh et al.   PANCREAS

Amino acid coevolution induces an evolutionary Stokes shift

(2012) D. D. Pollock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Smad4 Inactivation Promotes Malignancy and Drug Resistance of Colon Cancer

(2011) P. Papageorgis et al.   CANCER RESEARCH

Insights into the oncogenic effects of /PIK3CA/ mutations from the structure of p110α/p85α

(2011) Chuan-Hsiang Huang et al.   CELL CYCLE

From unwinding to clamping — the DEAD box RNA helicase family

(2011) Patrick Linder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutations in Protein-Binding Hot-Spots on the Hub Protein Smad3 Differentially Affect Its Protein Interactions and Smad3-Regulated Gene Expression

(2011) Michelle M. Schiro et al.   PLoS One

Large shifts in pKa values of lysine residues buried inside a protein

(2011) D. G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hot-spot mutations in p110α of phosphatidylinositol 3-kinase (PI3K): Differential interactions with the regulatory subunit p85 and with RAS

(2010) Li Zhao et al.   CELL CYCLE

Hypoxia and energetic tumour metabolism

(2010) M Christiane Brahimi-Horn et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Signatures of mutation and selection in the cancer genome

(2010) Graham R. Bignell et al.   NATURE

The Tumor Suppressor p53: From Structures to Drug Discovery

(2010) A. C. Joerger et al.   Cold Spring Harbor Perspectives in Biology

New insights into mechanisms of gastrointestinal inflammation and cancer

(2009) Stephen G Ward et al.   CURRENT OPINION IN PHARMACOLOGY

Tumor suppressors and cell metabolism: a recipe for cancer growth

(2009) R. G. Jones et al.   GENES & DEVELOPMENT

A frequent kinase domain mutation that changes the interaction between PI3K  and the membrane

(2009) D. Mandelker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular determinants of the pKavalues of Asp and Glu residues in staphylococcal nuclease

(2009) Carlos A. Castañeda et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

(2008) Christian Frantz et al.   JOURNAL OF CELL BIOLOGY

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling

(2008) J. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA