Contact Activation Inhibitor and Factor XI Antibody, AB023, Produces Safe, Dose-Dependent Anticoagulation in a Phase 1 First-In-Human Trial

Association of Intracerebral Hemorrhage Among Patients Taking Non–Vitamin K Antagonist vs Vitamin K Antagonist Oral Anticoagulants With In-Hospital Mortality

(2018) Taku Inohara et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Antibody-mediated inhibition of FXIIa blocks downstream bradykinin generation

(2018) Helen Cao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Factor XII Activation Promotes Platelet Consumption in the Presence of Bacterial-Type Long-Chain Polyphosphate In Vitro and In Vivo

(2018) Jevgenia Zilberman-Rudenko et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prospective, Randomized, Multicenter, Controlled Trial (TRIATHRON 1) on a New Antithrombogenic Hydrophilic Dialysis Membrane

(2017) Claudio Ronco et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

Intrapericardial Left Ventricular Assist Device for Advanced Heart Failure

(2017) Joseph G. Rogers et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

(2017) Liming Liu   Protein & Cell

Factor XI deficiency is associated with lower risk for cardiovascular and venous thromboembolism events

(2016) Meir Preis et al.   BLOOD

Factor XIa inhibitors: A review of the patent literature

(2016) Rami A. Al-Horani et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis

(2015) Harry R. Büller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates

(2013) Jeffrey R. Crosby et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dabigatran versus Warfarin in Patients with Mechanical Heart Valves

(2013) John W. Eikelboom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of factor XI activation attenuates inflammation and coagulopathy while improving the survival of mouse polymicrobial sepsis

(2012) E. I. Tucker et al.   BLOOD

Prevention of VTE in Nonorthopedic Surgical Patients

(2012) Michael K. Gould et al.   CHEST

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Factor XII-Mediated Activation of Factor XI Provides Protection Against Experimental Acute Ischemic Stroke in Mice

(2012) Philberta Y. Leung et al.   Translational Stroke Research

Factor XI-Deficient Mice Display Reduced Inflammation, Coagulopathy, and Bacterial Growth during Listeriosis

(2011) Deyan Luo et al.   INFECTION AND IMMUNITY

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

(2010) Q. Cheng et al.   BLOOD

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

(2010) Ophira Salomon et al.   THROMBOSIS AND HAEMOSTASIS

Factor XI contributes to thrombin generation in the absence of factor XII

(2009) D. V. Kravtsov et al.   BLOOD

Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)*

(2009) Fabián Jaimes et al.   CRITICAL CARE MEDICINE

Coagulation factor XII (FXII) activity, activated FXII, distribution ofFXIIC46T gene polymorphism and coronary risk

(2009) J. BACH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

(2008) E. I. Tucker et al.   BLOOD