Article
Medicine, General & Internal
A. Reum Choe, Chang Mo Moon, Chung Hyun Tae, Jaeyoung Chun, Ki Bae Bang, Yoo Jin Lee, Hyun Seok Lee, Yunho Jung, Sung Chul Park, Hoon Sup Koo
Summary: Patients on NOACs have lower rates of vascular lesions and small bowel bleeding compared to those on VKA, leading to better clinical outcomes such as reduced transfusion volumes and shorter ICU stays.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Josefine Grundtvig, Christian Ovesen, Inger Havsteen, Thomas Christensen, David Gaist, Helle K. Iversen, Christina Kruuse, Alexander Lilja-Cyron, Karen Aegidius, Sverre Rosenbaum, Per Meden, Jacob Marstrand, Louisa Christensen, Thorsten Steiner, Hanne Christensen
Summary: A study in the Capital Region of Denmark identified trends in the sales of oral anticoagulants, showing an increase in non-vitamin K antagonist oral anticoagulants (NOAC) sales and a decrease in vitamin K antagonists (VKA) sales from 2010 to 2017. While the total number of intracerebral hemorrhage (ICH) events remained stable, the proportion of OAC-related ICH events increased over the study period, with a significant rise in NOAC-related ICH events and a decrease in VKA-related ICH events.
EUROPEAN STROKE JOURNAL
(2021)
Article
Clinical Neurology
Josefine Grundtvig, Christian Ovesen, Thorsten Steiner, Cheryl Carcel, David Gaist, Louisa Christensen, Jacob Marstrand, Per Meden, Sverre Rosenbaum, Helle K. Iversen, Christina Kruuse, Thomas Christensen, Karen AEgidius, Inger Havsteen, Hanne Christensen
Summary: This study explores the similarities and differences in risk factors, acute presentation, treatments, and outcomes between men and women with oral anticoagulant-related intracerebral hemorrhage (ICH). The results show significant differences in age, risk factors, access to treatment, and do-not-resuscitate (DNR) orders between genders, but no significant differences in comorbidity burden, stroke severity, or hematoma volume. These findings support the presence of gender differences in risk factors and care, but not in presentation and outcomes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jin-Yi Hsu, Peter Pin-Sung Liu, An-Bang Liu, Shu-Man Lin, Huei-Kai Huang, Ching-Hui Loh
Summary: This study found that patients with AF using NOACs had a lower risk of dementia compared to those using warfarin, especially in the age group of 65 to 74 years with a high risk of stroke or bleeding.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Pharmacology & Pharmacy
Vincenzo Russo, Dario Fabiani
Summary: This review aims to explore the role of FXa and FIIa in the inflammation pathway and the potential anti-inflammatory effects of NOACs.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Joris J. Komen, Anton Pottegard, Aukje K. Mantel-Teeuwisse, Tomas Forslund, Paul Hjemdahl, Bjorn Wettermark, Jesper Hallas, Morten Olesen, Marion Bennie, Tanja Mueller, Raymond Carragher, Oystein Karlstad, Lars J. Kjerpeseth, Olaf H. Klungel
Summary: Observational data suggests that NOAC treatment may have a positive net clinical benefit compared with no treatment or VKA treatment in low stroke risk patients.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Xiaojuan Wu, Linyan Hu, Jinjin Liu, Qiuping Gu
Summary: This meta-analysis indicated that DOACs were associated with a reduced risk of any fracture compared to VKAs, especially apixaban and rivaroxaban. Further studies are needed to confirm these findings.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Elena Ivany, Deirdre A. Lane, Gheorghe-Andrei Dan, Wolfram Doehner, Michal M. Farkowski, Konstantinos Iliodromitis, Radoslaw Lenarczyk, Tatjana S. Potpara
Summary: The survey showed that the majority of doctors would prescribe oral anticoagulant therapy for patients with atrial fibrillation who have had an intracerebral haemorrhage, and would restart anticoagulant therapy more than 30 days post-ICH. The main reason for not prescribing antithrombotic therapy post-ICH was concern about recurrent intracerebral haemorrhage.
Article
Medicine, General & Internal
Anna Szpotowicz, Iwona Gorczyca, Olga Jelonek, Beata Uzieblo-Zyczkowska, Malgorzata Maciorowska, Maciej Wojcik, Robert Blaszczyk, Agnieszka Kaplon-Cieslicka, Monika Gawalko, Monika Budnik, Tomasz Tokarek, Renata Rajtar-Salwa, Jacek Bil, Michal Wojewodzki, Janusz Bednarski, Elwira Bakula-Ostalska, Anna Tomaszuk-Kazberuk, Anna Szyszkowska, Marcin Welnicki, Artur Mamcarz, Malgorzata Krzciuk, Beata Wozakowska-Kaplon
Summary: Most AF patients at high risk of thromboembolic complications received OACs, but certain medical conditions may result in the lack of OAC therapy in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Francesco De Stefano, Alberto Benassi, Alberto Maria Cappelletti, Francesco Donatelli, Damiano Regazzoli, Salvatore Tolaro, Francesca Perego, Angelo Silverio, Alessandra Scatteia, Pasquale Guarini, Santo Dellegrottaglie, Simona Mariani, Elpidio Pezzella, Gennaro Galasso, Francesco Caiazza
Summary: This study evaluated the real-world use of oral anticoagulant therapy in patients aged ≥80 years and investigated patient tolerance and satisfaction with the therapy. The majority of patients were treated with non-vitamin K antagonist oral anticoagulants (NOACs), with a small proportion receiving vitamin K antagonists (VKAs). Patients treated with NOACs reported a higher level of satisfaction and improved quality of life.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Mattia Brigida, Simona Di Caro, Carmine Petruzziello, Angela Saviano, Maria Elena Riccioni, Francesco Franceschi, Veronica Ojetti
Summary: This study compared the impact of warfarin and direct oral anticoagulants on the severity of upper gastrointestinal bleeding. The results showed that patients on warfarin had more severe bleeding, but this may be attributed to comorbidities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Rungroj Krittayaphong, Thanita Boonyapiphat, Suchart Aroonsiriwattana, Pornchai Ngamjanyaporn, Gregory Y. H. Lip
Summary: This study aimed to determine the causes of death in Asian non-valvular atrial fibrillation (AF) patients registered in a nationwide AF registry, and investigate the differences in causes of death between AF patients who were taking and not taking oral anticoagulant (OAC). The COOL-AF study in Thailand enrolled 3,405 non-valvular AF patients and found that non-cardiovascular death, such as infection/sepsis or malignancy, was more prevalent than cardiovascular death in Asian AF patients. Thus, an improved integrated care approach is needed to reduce non-cardiovascular death in Asian AF patients.
Article
Hematology
Yuxiang Zheng, Siyuan Li, Xiao Liu, Gregory Y. H. Lip, Linjuan Guo, Wengen Zhu
Summary: In atrial fibrillation patients with polypharmacy, non-vitamin K antagonist oral anticoagulants (NOACs) showed effectiveness in reducing the risk of stroke or systemic embolism compared to vitamin K antagonists (VKAs). However, there was no significant difference in major bleeding between the two groups.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Anita van de Munckhof, Mayte Sanchez van Kammen, Katarzyna Krzywicka, Sanjith Aaron, Diana Aguiar de Sousa, Florina Antochi, Antonio Arauz, Miguel A. Barboza, Adriana B. Conforto, Francesco Dentali, Daniel Galdames Contreras, Xunming Ji, Katarina Jood, Mirjam R. Heldner, Maria Hernandez-Perez, Wayneho Kam, Timothy J. Kleinig, Espen S. Kristoffersen, Ronen R. Leker, Robin Lemmens, Sven Poli, Niluefer Yesilot, Mohammad Wasay, Teddy Y. Wu, Marcel Arnold, Lia Lucas-Neto, Saskia Middeldorp, Jukka Putaala, Turgut Tatlisumak, Jose M. Ferro, Jonathan M. Coutinho, DOAC-CVT Study Grp
Summary: This study aims to compare the efficacy and safety of DOACs and VKAs for the prevention of recurrent venous thrombotic events in patients with CVT. DOAC-CVT will provide real-world data on the comparative effectiveness of DOACs versus VKAs in treating CVT.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Sonia Quintas, Gustavo Zapata-Wainberg, Susana Arias-Rivas, Alvaro Ximenez-Carrillo, Jose Castillo, Lorena Benavente Fernandez, Jaime Masjuan Vallejo, Maria del Mar Freijo Guerrero, Jose Egido, Andres Garcia Pastor, Pere Cardona, Aida Lago, Mar Castellanos Rodrigo, Blanca Fuentes, Monica Sobrado, Jose Vivancos
Summary: The incidence of oral anticoagulant-related intracerebral hemorrhage (ICH-OAC) in Spain has shown a 3.73-fold increase during the study period. The proportion of ICH-OAC out of total ICH increased from 8.4% in 2008 to 18.2% in 2015. The increase in ICH-OAC may be partly explained by aging of the population.
EUROPEAN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Sophie Hu, Scott Patten, Anna Charlton, Karyn Fischer, Gordon Fick, Eric E. Smith, Zahinoor Ismail
Summary: This study compared the utility of MBI-C and NPI-Q in capturing non-cognitive symptoms in patients with subjective cognitive decline, mild cognitive impairment, and dementia. The results showed that both MBI-C and NPI-Q were effective in characterizing these symptoms, and MBI-C was able to capture non-cognitive symptoms across different cognitive stages.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Rheumatology
Christina Charles-Schoeman, Maya H. Buch, Maxime Dougados, Deepak L. Bhatt, Jon T. Giles, Steven R. Ytterberg, Gary G. Koch, Ivana Vranic, Joseph Wu, Cunshan Wang, Kenneth Kwok, Sujatha Menon, Jose L. Rivas, Arne Yndestad, Carol A. Connell, Zoltan Szekanecz
Summary: This post hoc analysis observed a higher risk of MACE associated with tofacitinib compared to TNFi in RA patients with a history of ASCVD. Among patients without a history of ASCVD but with prevalent CV risk factors, there does not appear to be a difference in MACE risk between tofacitinib 5 mg twice daily and TNFi, although any absolute risk excess is likely low.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, Aymen Ahmed, Stephen J. Greene, Mona Fiuzat, Michelle M. Kittleson, Javed Butler, George L. Bakris, Gregg C. Fonarow
Summary: Heart failure and end-stage kidney disease often coexist and worsen each other's prognosis. Patients on dialysis are at high risk, but they have been excluded from major clinical trials on heart failure, resulting in a lack of data and reliance on observational evidence. In clinical practice, heart failure treatment is often reduced or discontinued in patients with end-stage kidney disease undergoing dialysis due to safety concerns. This review discusses the available evidence, challenges, and future directions for optimizing heart failure management in these high-risk patients.
JOURNAL OF CARDIAC FAILURE
(2023)
Article
Endocrinology & Metabolism
Rena Pollack, Itamar Raz, Stephen D. Wiviott, Erica L. Goodrich, Sabina A. Murphy, Ilan Yanuv, Aliza Rozenberg, Ofri Mosenzon, Anna Maria Langkilde, Ingrid A. M. Gause-Nilsson, Deepak L. Bhatt, Lawrence A. Leiter, Darren K. McGuire, John P. H. Wilding, Marc S. Sabatine, Avivit Cahn
Summary: This study explored the cardiorenal benefits of adding SGLT2 inhibitor therapy for patients on insulin. The results showed that dapagliflozin reduced cardiovascular and renal risks and had no significant impact on insulin dose and regimen.
Article
Medicine, Research & Experimental
Samuel C. R. Sherratt, Peter Libby, Hazem Dawoud, Deepak L. Bhatt, Tadeusz Malinski, R. Preston Mason
Summary: This study investigated the pro-inflammatory effects of air pollution PMs on pulmonary endothelial cell NO bioavailability and protein expression, and whether EPA can restore endothelial cell function. The results showed that EPA can alter protein expression related to inflammatory pathways and reduce the levels of the inflammatory molecule sICAM-1, improving the NO/ONOO- release ratio. These cellular changes may contribute to the anti-inflammatory, cytoprotective, and lipid changes associated with EPA treatment during air pollution exposure.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Hyeok-Hee Lee, Hokyou Lee, Deepak L. Bhatt, Ga Bin Lee, Jiyen Han, Dong Wook Shin, Danbee Kang, Jong-Chan Youn, Eliseo Guallar, Juhee Cho, Hyeon Chang Kim
EUROPEAN HEART JOURNAL
(2023)
Article
Health Care Sciences & Services
Meng Wang, Thierry Chekouo, Zahinoor Ismail, Nils D. Forkert, David B. Hogan, Aravind Ganesh, Richard Camicioli, Dallas Seitz, Michael J. Borrie, Ging-Yuek Robin Hsiung, Mario Masellis, Paige Moorhouse, Carmela Tartaglia, Eric E. Smith, Tolulope T. Sajobi
Summary: The study aimed to develop and validate a Bayesian risk prediction model combining research cohort data and expert knowledge to predict dementia progression in people with mild cognitive impairment (MCI). The results showed that adding expert knowledge did not improve the accuracy of the model in predicting dementia progression.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Muhammad Shariq Usman, Tariq Jamal Siddiqi, Stefan D. Anker, George L. Bakris, Deepak L. Bhatt, Gerasimos Filippatos, Gregg C. Fonarow, Stephen J. Greene, James L. Januzzi, Muhammad Shahzeb Khan, Mikhail N. Kosiborod, Darren K. McGuire, Ileana L. Pina, Julio Rosenstock, Muthiah Vaduganathan, Subodh Verma, Shelley Zieroth, Javed Butler
Summary: SGLT2 inhibitors can reduce the risk of heart failure events and cardiovascular death in patients with type 2 diabetes, heart failure, and chronic kidney disease, and the effects are consistent in patients with different combinations of these diseases.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Darryl Wan, Mahshid Dehghan, Russell J. de Souza, Chinthanie Ramasundarahettige, John W. Eikelboom, Jackie Bosch, Aldo P. Maggioni, Deepak L. Bhatt, Salim Yusuf, Sonia S. Anand
Summary: This study examined the association between dietary patterns and the risk of recurrent major adverse cardiovascular and limb events in patients with coronary artery disease (CAD) and peripheral artery disease (PAD). The findings suggest that poor diet quality is independently associated with a higher risk of such events.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Medical Informatics
Michelle Lu, Rachel E. Crooks, Diana F. Pricop, Emily Cox, Beatrice Anghelescu, Mark Hamilton, Davide Martino, Veronica Bruno, Colin B. Josephson, Scott Patten, Eric E. Smith, Pamela Roach
Summary: This study aimed to explore barriers and facilitators of virtual care from the perspective of neurological and psychiatric patients. One-on-one interviews were conducted remotely using telephone and online video teleconferencing, with a total of 57 participants. The study found that virtual care can increase accessibility and efficiency for patients and providers, indicating its potential for ongoing use in the delivery of clinical care. Patients perceived virtual care as an acceptable mode of healthcare delivery, but there remains a continued need for relationship-building between care providers and patients.
HEALTH AND TECHNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: In a large cohort of adults with type 2 diabetes, the study found a significant association between cardiac autonomic neuropathy (CAN) and the risk of silent myocardial infarction (SMI). Low heart rate variability was significantly associated with an increased risk of incident SMI. Participants with CAN had a 1.9-fold greater risk of SMI.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Bertram Pitt, Deepak L. Bhatt, Michael Szarek, Christopher P. Cannon, Lawrence A. Leiter, Darren K. Mcguire, Julia B. Lewis, Matthew C. Riddle, Adriaan A. Voors, Marco Metra, Lars H. Lund, Michel Komajda, Jeffrey M. Testani, Christopher S. Wilcox, Piotr Ponikowski, Renato D. Lopes, Justin A. Ezekowitz, Franklin Sun, Michael J. Davies, Subodh Verma, Mikhail N. Kosiborod, SOLOIST WHF Investigators
Summary: The study finds that starting sotagliflozin before discharge in type 2 diabetes patients hospitalized for WHF can significantly decrease cardiovascular deaths and HF events through 30 and 90 days after discharge. However, sotagliflozin may have slightly higher rates of diarrhea and volume-related events compared to placebo.
JACC-HEART FAILURE
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Mikhail Kosiborod, Deepak L. Bhatt, Michael Szarek, Philippe Gabriel Steg, Bertram Pitt
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Samuel C. R. R. Sherratt, Peter Libby, Deepak L. Bhatt, R. Preston Mason
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Clinical Neurology
Jay Lusk, Ailin Song, Shakhthi Unnithan, Hussein Al-Khalidi, Jonathan Piccini, Ying Xian, Emily O'Brien, Brian Mac Grory