Hyaluronidase with pH‐responsive Dextran Modification as an Adjuvant Nanomedicine for Enhanced Photodynamic‐Immunotherapy of Cancer

Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade

(2019) Fangyuan Zhou et al.   ADVANCED MATERIALS

Drug delivery systems targeting tumor-associated fibroblasts for cancer immunotherapy

(2019) Mengrui Liu et al.   CANCER LETTERS

Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy

(2018) Wenfei Chen et al.   ACS Nano

Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase

(2018) Xiuwen Guan et al.   BIOMATERIALS

Nanoscale covalent organic polymers as a biodegradable nanomedicine for chemotherapy-enhanced photodynamic therapy of cancer

(2018) Hairong Wang et al.   Nano Research

Photosensitizer-crosslinked in-situ polymerization on catalase for tumor hypoxia modulation & enhanced photodynamic therapy

(2018) Hairong Wang et al.   BIOMATERIALS

Microneedle-Assisted Topical Delivery of Photodynamically Active Mesoporous Formulation for Combination Therapy of Deep-Seated Melanoma

(2018) Huijun Phoebe Tham et al.   ACS Nano

Extracellular matrix (ECM) stiffness and degradation as cancer drivers

(2018) Masoud Najafi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

(2017) Guangbao Yang et al.   Nature Communications

Extracellular matrix structure

(2016) Achilleas D. Theocharis et al.   ADVANCED DRUG DELIVERY REVIEWS

Catalase-Loaded TaOx Nanoshells as Bio-Nanoreactors Combining High-Z Element and Enzyme Delivery for Enhancing Radiotherapy

(2016) Guosheng Song et al.   ADVANCED MATERIALS

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

(2016) Hua Gong et al.   NANO LETTERS

Breaching the Hyaluronan Barrier with PH20-Fc Facilitates Intratumoral Permeation and Enhances Antitumor Efficiency: A Comparative Investigation of Typical Therapeutic Agents in Different Nanoscales

(2016) Shan Liu et al.   Advanced Healthcare Materials

Co-delivery of paclitaxel and gemcitabine via CD44-targeting nanocarriers as a prodrug with synergistic antitumor activity against human biliary cancer

(2015) Ilkoo Noh et al.   BIOMATERIALS

Tumor microenvironment: Sanctuary of the devil

(2015) Lanlan Hui et al.   CANCER LETTERS

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

Combination of Photodynamic Therapy and Specific Immunotherapy Efficiently Eradicates Established Tumors

(2015) J. W. Kleinovink et al.   CLINICAL CANCER RESEARCH

PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy

(2015) S. P. Patel et al.   MOLECULAR CANCER THERAPEUTICS

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials-Science & Engineering

High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation

(2015) Jamie E. Rayahin et al.   ACS Biomaterials Science & Engineering

Hyperthermia-Mediated Local Drug Delivery by a Bubble-Generating Liposomal System for Tumor-Specific Chemotherapy

(2014) Ko-Jie Chen et al.   ACS Nano

Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment

(2014) Mathumai Kanapathipillai et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of photodynamic therapy regimens that control primary tumor growth and inhibit secondary disease

(2014) Madeeha Shams et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

Improving Conventional Enhanced Permeability and Retention (EPR) Effects; What Is the Appropriate Target?

(2014) Hisataka Kobayashi et al.   Theranostics

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

Targeting the PD1/PD-L1 axis in melanoma: Biological rationale, clinical challenges and opportunities

(2013) Barbara Merelli et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The tumor microenvironment at a glance

(2013) F. R. Balkwill et al.   JOURNAL OF CELL SCIENCE

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

Tumor Microenvironment Complexity: Emerging Roles in Cancer Therapy

(2012) M. A. Swartz et al.   CANCER RESEARCH

Cytokine Network: New Targeted Therapy for Pancreatic Cancer

(2012) Yoichi Matsuo et al.   CURRENT PHARMACEUTICAL DESIGN

Acid-Labile Traceless Click Linker for Protein Transduction

(2012) Kevin Maier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

(2011) Andrea Facciabene et al.   NATURE

Multi-enzyme systems: bringing enzymes together in vitro

(2011) Sanne Schoffelen et al.   Soft Matter

Enhanced Systemic Immune Reactivity to a Basal Cell Carcinoma Associated Antigen Following Photodynamic Therapy

(2009) E. Kabingu et al.   CLINICAL CANCER RESEARCH

Cancer and the tumor microenvironment: a review of an essential relationship

(2008) Flaubert Mbeunkui et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Hypoxia-Adenosinergic Immunosuppression: Tumor Protection by T Regulatory Cells and Cancerous Tissue Hypoxia

(2008) M. V. Sitkovsky et al.   CLINICAL CANCER RESEARCH

Diffusion in Brain Extracellular Space

(2008) Eva Syková et al.   PHYSIOLOGICAL REVIEWS