Extracellular matrix (ECM) stiffness and degradation as cancer drivers

The Presence of Cyclooxygenase 2, Tumor-Associated Macrophages, and Collagen Alignment as Prognostic Markers for Invasive Breast Carcinoma Patients

(2018) Karla Esbona et al.   AMERICAN JOURNAL OF PATHOLOGY

Transforming growth factor-β modulates pancreatic cancer associated fibroblasts cell shape, stiffness and invasion

(2018) Andreas Stylianou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance

(2018) Douglas E. Biancur et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Stromal cell-laden 3D hydrogel microwell arrays as tumor microenvironment model for studying stiffness dependent stromal cell-cancer interactions

(2018) Xiaoshan Yue et al.   BIOMATERIALS

LW106, a novel indoleamine 2,3-dioxygenase 1 inhibitor, suppresses tumour progression by limiting stroma-immune crosstalk and cancer stem cell enrichment in tumour micro-environment

(2018) Rong Fu et al.   BRITISH JOURNAL OF PHARMACOLOGY

T Cell Dysfunction in Cancer

(2018) Daniela S. Thommen et al.   CANCER CELL

Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages

(2018) Jianjun Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A peek into cancer-associated fibroblasts: origins, functions and translational impact

(2018) Valerie S. LeBleu et al.   Disease Models & Mechanisms

A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy

(2018) Masahiro Shibata et al.   INTERNATIONAL JOURNAL OF CANCER

Human hepatocellular carcinoma: Protection by melatonin

(2018) Keywan Mortezaee   JOURNAL OF CELLULAR PHYSIOLOGY

Quantifying solid stress and elastic energy from excised or in situ tumors

(2018) Hadi T Nia et al.   Nature Protocols

Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation

(2018) Dinesh K. Ahirwar et al.   ONCOGENE

Histone deacetylase 6 regulates the immunosuppressive properties of cancer-associated fibroblasts in breast cancer through the STAT3–COX2-dependent pathway

(2018) Ang Li et al.   ONCOGENE

Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features

(2018) Sharathchandra Arandkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual-targeting biomimetic delivery for anti-glioma activity via remodeling the tumor microenvironment and directing macrophage-mediated immunotherapy

(2018) Pengfei Zhao et al.   Chemical Science

Proton irradiation orchestrates macrophage reprogramming through NFκB signaling

(2018) Géraldine Genard et al.   Cell Death & Disease

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

Intravital microscopy in the study of the tumor microenvironment: from bench to human application

(2018) Emmanuel M. Gabriel et al.   Oncotarget

The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation

(2018) Andrew J. McKenzie et al.   Scientific Reports

Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics

(2018) Laura M. Urbanski et al.   Wiley Interdisciplinary Reviews-RNA

Fibronectin Promotes the Malignancy of Glioma Stem-Like Cells Via Modulation of Cell Adhesion, Differentiation, Proliferation and Chemoresistance

(2018) Qi Yu et al.   Frontiers in Molecular Neuroscience

The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer

(2018) Shamila D. Alipoor et al.   Frontiers in Immunology

Contribution to Tumor Angiogenesis From Innate Immune Cells Within the Tumor Microenvironment: Implications for Immunotherapy

(2018) Adriana Albini et al.   Frontiers in Immunology

M7824, a novel bifunctional anti-PD-L1/TGFβ Trap fusion protein, promotes anti-tumor efficacy as monotherapy and in combination with vaccine

(2018) Karin M. Knudson et al.   OncoImmunology

Influence of the Tumor Microenvironment on Cancer Cells Metabolic Reprogramming

(2018) Victoire Gouirand et al.   Frontiers in Oncology

Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

(2018) Vasiliki Gkretsi et al.   Frontiers in Oncology

Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation

(2017) Sara K. Donnelly et al.   JOURNAL OF CELL BIOLOGY

Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer

(2017) Gajendra K. Katara et al.   Molecular Oncology

Cancer-associated fibroblasts induce cancer cell apoptosis that regulates invasion mode of tumours

(2017) G Itoh et al.   ONCOGENE

Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts

(2017) Balaji Krishnamachary et al.   Oncotarget

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

(2017) Anisha M. Hammer et al.   NEOPLASIA

In vitro cancer cell–ECM interactions inform in vivo cancer treatment

(2016) Andrew W. Holle et al.   ADVANCED DRUG DELIVERY REVIEWS

Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases

(2016) N. N. Rahbari et al.   Science Translational Medicine

Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway

(2016) Laura Lagares-Tena et al.   Oncotarget

Stromal fibroblasts facilitate cancer cell invasion by a novel invadopodia-independent matrix degradation process

(2015) H Cao et al.   ONCOGENE

ECM stiffness regulates glial migration in Drosophila and mammalian glioma models

(2014) S. N. Kim et al.   DEVELOPMENT

The extracellular matrix modulates the hallmarks of cancer

(2014) M. W. Pickup et al.   EMBO REPORTS

Bioengineered 3D Brain Tumor Model To Elucidate the Effects of Matrix Stiffness on Glioblastoma Cell Behavior Using PEG-Based Hydrogels

(2014) Christine Wang et al.   MOLECULAR PHARMACEUTICS

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Remodelling the extracellular matrix in development and disease

(2014) Caroline Bonnans et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability

(2014) E Martín-Villar et al.   ONCOGENE

Oxidative stress and cancer: An overview

(2012) Venus Sosa et al.   AGEING RESEARCH REVIEWS

Knockdown of glucose-regulated protein 78 decreases the invasion, metalloproteinase expression and ECM degradation in hepatocellular carcinoma cells

(2012) Hongdan Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Role of MMP-2 in the regulation of IL-6/Stat3 survival signaling via interaction with α5β1 integrin in glioma

(2012) D Kesanakurti et al.   ONCOGENE

Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-myc expression

(2010) Wilbur A Lam et al.   Molecular Cancer

Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion

(2010) Dimitra Bourboulia et al.   SEMINARS IN CANCER BIOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL