BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice

(2019) Valentina M. Lionello et al.   Science Translational Medicine

Characteristics of TBS-Extractable Hyperphosphorylated Tau Species: Aggregation Intermediates in rTg4510 Mouse Brain

(2018) Naruhiko Sahara et al.   JOURNAL OF ALZHEIMERS DISEASE

Elucidation of the BACE1 Regulating Factor GGA3 in Alzheimer's Disease

(2018) Teemu Natunen et al.   JOURNAL OF ALZHEIMERS DISEASE

Bridging Integrator 1 (BIN1) Protein Expression Increases in the Alzheimer's Disease Brain and Correlates with Neurofibrillary Tangle Pathology

(2018) Christopher J. Holler et al.   JOURNAL OF ALZHEIMERS DISEASE

Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: The forgotten partner

(2018) Isidro Ferrer   PROGRESS IN NEUROBIOLOGY

Structural Basis of Tau Interaction With BIN1 and Regulation by Tau Phosphorylation

(2018) Alessia Lasorsa et al.   Frontiers in Molecular Neuroscience

Regulation of the interaction between the neuronal BIN1 isoform 1 and Tau proteins - role of the SH3 domain

(2017) Idir Malki et al.   FEBS Journal

Cognitive Decline in Preclinical Alzheimer’s Disease: Amyloid-Beta versus Tauopathy

(2017) Colin M. Huber et al.   JOURNAL OF ALZHEIMERS DISEASE

Amphiphysin (BIN1) negatively regulates dynamin 2 for normal muscle maturation

(2017) Belinda S. Cowling et al.   JOURNAL OF CLINICAL INVESTIGATION

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

(2017) Andrew T. McKenzie et al.   Molecular Neurodegeneration

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

(2017) Rebecca Sims et al.   NATURE GENETICS

Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism

(2016) Julien Chapuis et al.   ACTA NEUROPATHOLOGICA

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production

(2016) Toji Miyagawa et al.   HUMAN MOLECULAR GENETICS

Characterization of Neuronal Tau Protein as a Target of Extracellular Signal-regulated Kinase

(2016) Haoling Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Predominant expression of Alzheimer’s disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts

(2016) Pierre De Rossi et al.   Molecular Neurodegeneration

Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology

(2016) P Dourlen et al.   MOLECULAR PSYCHIATRY

Loss of Bin1 Promotes the Propagation of Tau Pathology

(2016) Sara Calafate et al.   Cell Reports

Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain

(2015) Yoann Sottejeau et al.   Acta Neuropathologica Communications

Amphiphysin 2 (BIN1) in physiology and diseases

(2014) Ivana Prokic et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

(2014) Hans Zempel et al.   TRENDS IN NEUROSCIENCES

Genome-Wide Association Meta-analysis of Neuropathologic Features of Alzheimer's Disease and Related Dementias

(2014) Gary W. Beecham et al.   PLoS Genetics

The global prevalence of dementia: A systematic review and metaanalysis

(2013) Martin Prince et al.   Alzheimers & Dementia

Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms

(2013) J. M. Shulman et al.   HUMAN MOLECULAR GENETICS

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

(2013) Carlos Cruchaga et al.   NEURON

BIN1 Is Decreased in Sporadic but Not Familial Alzheimer’s Disease or in Aging

(2013) Elizabeth B. C. Glennon et al.   PLoS One

Distinct Roles of Medial and Lateral Entorhinal Cortex in Spatial Cognition

(2012) T. Van Cauter et al.   CEREBRAL CORTEX

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex

(2012) Gerard M J Beaudoin et al.   Nature Protocols

Functional Screening of Alzheimer Pathology Genome-wide Association Signals in Drosophila

(2011) Joshua M. Shulman et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Deciphering genetic susceptibility to frontotemporal lobar dementia

(2010) Jean-Charles Lambert et al.   NATURE GENETICS

Age-Dependent Impairment of Cognitive and Synaptic Function in the htau Mouse Model of Tau Pathology

(2009) M. Polydoro et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS