Uniform Widespread Nuclear Phosphorylation of Histone H2AX Is an Indicator of Lethal DNA Replication Stress

The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors

(2018) Leslie A. Parsels et al.   CELL CYCLE

Imaging of native transcription factors and histone phosphorylation at high resolution in live cells

(2018) Sascha Conic et al.   JOURNAL OF CELL BIOLOGY

Targeting the replication stress response in cancer

(2018) Josep V. Forment et al.   PHARMACOLOGY & THERAPEUTICS

ATR/CHK1 inhibitors and cancer therapy

(2018) Zhaojun Qiu et al.   RADIOTHERAPY AND ONCOLOGY

Gamma-H2AX immunofluorescence for the detection of tissue-specific genotoxicity in vivo

(2018) Ulla Plappert-Helbig et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Chromatin as a Platform for Modulating the Replication Stress Response

(2018) Louis-Alexandre Fournier et al.   Genes

Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oncogene-Induced Replication Stress Drives Genome Instability and Tumorigenesis

(2017) Dan Sarni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Around and beyond 53BP1 Nuclear Bodies

(2017) Anne Fernandez-Vidal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

(2017) Luis Toledo et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Phosphorylated fraction of H2AX as a measurement for DNA damage in cancer cells and potential applications of a novel assay

(2017) Jiuping Ji et al.   PLoS One

Identification of the elementary structural units of the DNA damage response

(2017) Francesco Natale et al.   Nature Communications

Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine

(2017) Kelli L. Goss et al.   Oncotarget

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation

(2017) Mayu Isono et al.   Cell Reports

Targeting the replisome with transduced monoclonal antibodies triggers lethal DNA replication stress in cancer cells

(2016) Dominique Desplancq et al.   EXPERIMENTAL CELL RESEARCH

Chromosomal breaks during mitotic catastrophe trigger γH2AX–ATM–p53-mediated apoptosis

(2016) Gabriela Imreh et al.   JOURNAL OF CELL SCIENCE

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

(2016) Kumar Sanjiv et al.   Cell Reports

Targeting DNA Replication Stress for Cancer Therapy

(2016) Jun Zhang et al.   Genes

The Cell Killing Mechanisms of Hydroxyurea

(2016) Amanpreet Singh et al.   Genes

Alpha particles induce pan-nuclear phosphorylation of H2AX in primary human lymphocytes mediated through ATM

(2015) Simon Horn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

CHK1 Inhibition Synergizes with Gemcitabine Initially by Destabilizing the DNA Replication Apparatus

(2015) S.-B. Koh et al.   CANCER RESEARCH

Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development

(2015) Isabelle Buisson et al.   DEVELOPMENTAL BIOLOGY

Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells

(2015) Pedro Zuazua-Villar et al.   NUCLEIC ACIDS RESEARCH

RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response

(2014) Alexandre Maréchal et al.   CELL RESEARCH

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe

(2014) Amanda K. Ashley et al.   DNA REPAIR

The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response

(2014) Teodora Nikolova et al.   TOXICOLOGICAL SCIENCES

Targeting endogenous nuclear antigens by electrotransfer of monoclonal antibodies in living cells

(2013) Guillaume Freund et al.   mAbs

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

(2013) Barbara Meyer et al.   NUCLEIC ACIDS RESEARCH

γ-H2AX and other histone post-translational modifications in the clinic

(2012) Christophe E. Redon et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

In-solution staining and arraying method for the immunofluorescence detection of γH2AX foci optimized for clinical applications

(2012) Pegah Johansson et al.   BIOTECHNIQUES

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Correction: γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers

(2012) Shibo Fu et al.   PLoS One

Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research

(2011) Alesia Ivashkevich et al.   CANCER LETTERS

DNA-PK-Dependent RPA2 Hyperphosphorylation Facilitates DNA Repair and Suppresses Sister Chromatid Exchange

(2011) Hungjiun Liaw et al.   PLoS One

Functional relevance of the histone  H2Ax in the response to DNA damaging agents

(2011) I. Revet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1

(2010) Mary E. Gagou et al.   MOLECULAR BIOLOGY OF THE CELL

A minority of foci or pan-nuclear apoptotic staining of  H2AX in the S phase after UV damage contain DNA double-strand breaks

(2010) S. de Feraudy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of Dynamic γ-H2AX Domains along Broken DNA Strands Is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

(2009) Velibor Savic et al.   MOLECULAR CELL

Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response

(2009) Maria Quanz et al.   PLoS One

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH