Methylation array profiling of adult brain tumours: diagnostic outcomes in a large, single centre

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

(2018) Mitsuaki Shirahata et al.   ACTA NEUROPATHOLOGICA

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

(2018) David Capper et al.   ACTA NEUROPATHOLOGICA

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

(2018) Annekathrin Reinhardt et al.   ACTA NEUROPATHOLOGICA

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features

(2018) Maximilian Y. Deng et al.   ACTA NEUROPATHOLOGICA

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

(2018) Christian Koelsche et al.   MODERN PATHOLOGY

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma

(2018) Damian Stichel et al.   ACTA NEUROPATHOLOGICA

Integrated molecular characterization of IDH -mutant glioblastomas

(2018) A. Korshunov et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study

(2017) Edward C Schwalbe et al.   LANCET ONCOLOGY

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

(2017) Felix Sahm et al.   LANCET ONCOLOGY

Cost-effectiveness of IDH testing in diffuse gliomas according to the 2016 WHO classification of tumors of the central nervous system recommendations

(2017) John C DeWitt et al.   NEURO-ONCOLOGY

Role of Immunohistochemistry in the Identification of Supratentorial C11ORF95-RELA Fused Ependymoma in Routine Neuropathology

(2017) Marco Gessi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Methylation-based classification of benign and malignant peripheral nerve sheath tumors

(2016) Manuel Röhrich et al.   ACTA NEUROPATHOLOGICA

Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology

(2016) Ibrahim Qaddoumi et al.   ACTA NEUROPATHOLOGICA

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants

(2016) Kristian W. Pajtler et al.   ACTA NEUROPATHOLOGICA

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

(2016) Dominik Sturm et al.   CELL

Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

(2015) David Castel et al.   ACTA NEUROPATHOLOGICA

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

(2015) David E. Reuss et al.   ACTA NEUROPATHOLOGICA

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

(2015) Kristian W. Pajtler et al.   CANCER CELL

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas

(2015) Heather E. Leeper et al.   Oncotarget

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

(2014) Benedikt Wiestler et al.   ACTA NEUROPATHOLOGICA

Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma

(2014) Felix Sahm et al.   ACTA NEUROPATHOLOGICA

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

(2014) David E. Reuss et al.   ACTA NEUROPATHOLOGICA

What do we know about IDH1/2 mutations so far, and how do we use it?

(2013) Craig Horbinski   ACTA NEUROPATHOLOGICA

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

(2013) Volker Hovestadt et al.   ACTA NEUROPATHOLOGICA

A population-based study of low-grade gliomas and mutated isocitrate dehydrogenase 1 (IDH1)

(2013) Rikke H. Dahlrot et al.   JOURNAL OF NEURO-ONCOLOGY

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

(2012) Xiao-Yang Liu et al.   ACTA NEUROPATHOLOGICA

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody

(2011) David Capper et al.   ACTA NEUROPATHOLOGICA

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma

(2011) Genevieve Schindler et al.   ACTA NEUROPATHOLOGICA

IDH testing in diagnostic neuropathology: review and practical guideline article invited by the Euro-CNS research committee

(2011) M. Preusser et al.   CLINICAL NEUROPATHOLOGY

A DNA methylation fingerprint of 1628 human samples

(2011) A. F. Fernandez et al.   GENOME RESEARCH

Monoclonal antibody specific for IDH1 R132H mutation

(2009) David Capper et al.   ACTA NEUROPATHOLOGICA

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

(2009) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

IDH1 Mutations as Molecular Signature and Predictive Factor of Secondary Glioblastomas

(2009) S. Nobusawa et al.   CLINICAL CANCER RESEARCH

Analysis of the IDH1 codon 132 mutation in brain tumors

(2008) Jörg Balss et al.   ACTA NEUROPATHOLOGICA

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols