Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

(2018) Mitsuaki Shirahata et al.   ACTA NEUROPATHOLOGICA

cIMPACT-NOW update 1: Not Otherwise Specified (NOS) and Not Elsewhere Classified (NEC)

(2018) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations

(2018) Annekathrin Reinhardt et al.   ACTA NEUROPATHOLOGICA

DNA methylation-based reclassification of olfactory neuroblastoma

(2018) David Capper et al.   ACTA NEUROPATHOLOGICA

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features

(2018) Maximilian Y. Deng et al.   ACTA NEUROPATHOLOGICA

Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations and DNA methylation profiling

(2018) Klaus Griewank et al.   CLINICAL CANCER RESEARCH

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle

(2018) Benjamin Goode et al.   Nature Communications

Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report

(2018) Moatasem El-Ayadi et al.   Frontiers in Neurology

DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

(2017) Felix Sahm et al.   LANCET ONCOLOGY

Methylation-based classification of benign and malignant peripheral nerve sheath tumors

(2016) Manuel Röhrich et al.   ACTA NEUROPATHOLOGICA

Announcing cIMPACT-NOW: the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

(2016) Pascal D. Johann et al.   CANCER CELL

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

(2016) Dominik Sturm et al.   CELL

Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study

(2016) Barbara C. Worst et al.   EUROPEAN JOURNAL OF CANCER

Somatic mutations ofDICER1andKMT2Dare frequent in intraocular medulloepitheliomas

(2016) Felix Sahm et al.   GENES CHROMOSOMES & CANCER

Sensitivity Analysis of the MGMT-STP27 Model and Impact of Genetic and Epigenetic Context to Predict the MGMT Methylation Status in Gliomas and Other Tumors

(2016) Pierre Bady et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups

(2016) Christian Thomas et al.   NEURO-ONCOLOGY

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

(2015) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

(2015) Felix Sahm et al.   ACTA NEUROPATHOLOGICA

Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity

(2015) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities

(2015) David E. Reuss et al.   ACTA NEUROPATHOLOGICA

Papillary Tumor of the Pineal Region: A Distinct Molecular Entity

(2015) Stephanie Heim et al.   BRAIN PATHOLOGY

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

(2015) Kristian W. Pajtler et al.   CANCER CELL

Mutational landscape and clonal architecture in grade II and III gliomas

(2015) Hiromichi Suzuki et al.   NATURE GENETICS

Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities

(2015) Andrey Korshunov et al.   NEUROPATHOLOGY

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Oligoastrocytomas: throwing the baby out with the bathwater?

(2014) Paul Wilcox et al.   ACTA NEUROPATHOLOGICA

Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma

(2014) Benedikt Wiestler et al.   ACTA NEUROPATHOLOGICA

Mixed glioma with molecular features of composite oligodendroglioma and astrocytoma: a true “oligoastrocytoma”?

(2014) Jason T. Huse et al.   ACTA NEUROPATHOLOGICA

ATRX and IDH1-R132H immunohistochemistry with subsequent copy number analysis and IDH sequencing as a basis for an “integrated” diagnostic approach for adult astrocytoma, oligodendroglioma and glioblastoma

(2014) David E. Reuss et al.   ACTA NEUROPATHOLOGICA

Melanotic Tumors of the Nervous System are Characterized by Distinct Mutational, Chromosomal and Epigenomic Profiles

(2014) Christian Koelsche et al.   BRAIN PATHOLOGY

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Trilateral retinoblastoma: a systematic review and meta-analysis

(2014) Marcus C de Jong et al.   LANCET ONCOLOGY

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

(2014) Volker Hovestadt et al.   NATURE

C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

(2014) Matthew Parker et al.   NATURE

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas

(2014) Priscilla K Brastianos et al.   NATURE GENETICS

Mutant BRAF V600E protein in ganglioglioma is predominantly expressed by neuronal tumor cells

(2013) Christian Koelsche et al.   ACTA NEUROPATHOLOGICA

SDH Mutations Establish a Hypermethylator Phenotype in Paraganglioma

(2013) Eric Letouzé et al.   CANCER CELL

BRAF V600E expression and distribution in desmoplastic infantile astrocytoma/ganglioglioma

(2013) C. Koelsche et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity

(2012) Fausto J. Rodriguez et al.   ACTA NEUROPATHOLOGICA

MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and CIMP-status

(2012) Pierre Bady et al.   ACTA NEUROPATHOLOGICA

Long-Term Epilepsy-Associated Tumors

(2012) Maria Thom et al.   BRAIN PATHOLOGY

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma

(2011) Hendrik Witt et al.   CANCER CELL

A DNA methylation fingerprint of 1628 human samples

(2011) A. F. Fernandez et al.   GENOME RESEARCH

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY