Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease
出版年份 2019 全文链接
标题
Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease
作者
关键词
Molecular targets, Neuron degeneration, Parkinson’s disease, Protein aggregation, Protein translation, Proteostasis
出版物
Translational Neurodegeneration
Volume 8, Issue 1, Pages -
出版商
Springer Nature
发表日期
2019-02-04
DOI
10.1186/s40035-019-0145-0
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Effect of leucine-rich repeat kinase 2 (LRRK2) on protein synthesis
- (2018) Hyejung Kim et al. Animal Cells and Systems
- Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease
- (2018) Xiaotian Sun et al. EXPERIMENTAL NEUROLOGY
- The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway
- (2018) Daniel Hughes et al. FEBS Journal
- Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease
- (2018) Gabriela Mercado et al. NEUROBIOLOGY OF DISEASE
- mTOR Cross-Talk in Cancer and Potential for Combination Therapy
- (2018) Fabiana Conciatori et al. Cancers
- Identification of potential therapeutic compounds for Parkinson's disease using Drosophila and human cell models
- (2017) Francisco José Sanz et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pathways of cellular proteostasis in aging and disease
- (2017) Courtney L. Klaips et al. JOURNAL OF CELL BIOLOGY
- Regulation of mRNA Translation in Neurons—A Matter of Life and Death
- (2017) Mridu Kapur et al. NEURON
- Combating Parkinson’s disease-associated toxicity by modulating proteostasis
- (2017) Yangshin Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c
- (2017) Hongrui Meng et al. Nature Communications
- Protein misfolding, amyotrophic lateral sclerosis and guanabenz: protocol for a phase II RCT with futility design (ProMISe trial)
- (2017) Eleonora Dalla Bella et al. BMJ Open
- PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
- (2017) Ana Crespillo-Casado et al. eLife
- 4E-BP1, a multifactor regulated multifunctional protein
- (2016) Xiaoyu Qin et al. CELL CYCLE
- Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot
- (2016) Deborah C.I. Goberdhan et al. Cell Metabolism
- Role of ribosomal protein mutations in tumor development (Review)
- (2016) KAVEH M. GOUDARZI et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Walking the tightrope: proteostasis and neurodegenerative disease
- (2016) Justin J. Yerbury et al. JOURNAL OF NEUROCHEMISTRY
- mTORC1 and mTORC2 in cancer and the tumor microenvironment
- (2016) L C Kim et al. ONCOGENE
- Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis
- (2016) J Musa et al. ONCOGENE
- Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease
- (2016) I Celardo et al. Cell Death & Disease
- UNC-51-like kinase 1 blocks S6k1 phosphorylation contributes to neurodegeneration in Parkinson's disease model in vitro
- (2015) Yongle Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations
- (2015) V. Ljungstrom et al. BLOOD
- Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders
- (2015) Kenneth Maiese BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Differential Requirements for eIF4E Dose in Normal Development and Cancer
- (2015) Morgan L. Truitt et al. CELL
- PINK1 and Parkin Control Localized Translation of Respiratory Chain Component mRNAs on Mitochondria Outer Membrane
- (2015) Stephan Gehrke et al. Cell Metabolism
- Neuronal Aggregates: Formation, Clearance, and Spreading
- (2015) Junghyun Lim et al. DEVELOPMENTAL CELL
- Neuroprotective agents target molecular mechanisms of disease in ALS
- (2015) Yongjin Zhu et al. DRUG DISCOVERY TODAY
- CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study
- (2015) Manabu Funayama et al. LANCET NEUROLOGY
- EIF4G1 mutations do not cause Parkinson's disease
- (2015) Noah Nichols et al. NEUROBIOLOGY OF AGING
- Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
- (2015) Nripesh Dhungel et al. NEURON
- D620N mutation in the VPS35 gene and R1205H mutation in the EIF4G1 gene are uncommon in the Greek population
- (2015) Kallirhoe Kalinderi et al. NEUROSCIENCE LETTERS
- An eIF2α-binding motif in protein phosphatase 1 subunit GADD34 and its viral orthologs is required to promote dephosphorylation of eIF2α
- (2015) Margarito Rojas et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes
- (2015) Mychael V. Lourenco et al. PROGRESS IN NEUROBIOLOGY
- Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
- (2015) I. Das et al. SCIENCE
- Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
- (2015) M Halliday et al. Cell Death & Disease
- Exploring Internal Ribosome Entry Sites as Therapeutic Targets
- (2015) Anton A. Komar et al. Frontiers in Oncology
- Could the eIF2α-Independent Translation Be the Achilles Heel of Cancer?
- (2015) Martin Holcik Frontiers in Oncology
- Role of translation initiation factor 4G in lifespan regulation and age-related health
- (2014) Amber Howard et al. AGEING RESEARCH REVIEWS
- Translational Control in Synaptic Plasticity and Cognitive Dysfunction
- (2014) Shelly A. Buffington et al. Annual Review of Neuroscience
- Structure and Function of Pre-mRNA 5′-End Capping Quality Control and 3′-End Processing
- (2014) Ashley R. Jurado et al. BIOCHEMISTRY
- Ribosomal Protein s15 Phosphorylation Mediates LRRK2 Neurodegeneration in Parkinson’s Disease
- (2014) Ian Martin et al. CELL
- Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
- (2014) Yijiao Xu et al. CELLULAR SIGNALLING
- Genetic dissection reveals that Akt is the critical kinase downstream of LRRK2 to phosphorylate and inhibit FOXO1, and promotes neuron survival
- (2014) Chia-Lung Chuang et al. HUMAN MOLECULAR GENETICS
- Human Eukaryotic Initiation Factor 2 (eIF2)-GTP-Met-tRNAiTernary Complex and eIF3 Stabilize the 43 S Preinitiation Complex
- (2014) Masaaki Sokabe et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- EIF4G1is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts: Table1
- (2014) Johanna Huttenlocher et al. JOURNAL OF MEDICAL GENETICS
- Loss of PINK1 Attenuates HIF-1 Induction by Preventing 4E-BP1-Dependent Switch in Protein Translation under Hypoxia
- (2014) W. Lin et al. JOURNAL OF NEUROSCIENCE
- Celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells
- (2014) JUAN MA et al. ONCOLOGY REPORTS
- EIF4G1 gene mutations are not a common cause of Parkinson's disease in the Japanese population
- (2014) Kenya Nishioka et al. PARKINSONISM & RELATED DISORDERS
- Guanabenz Interferes with ER Stress and Exerts Protective Effects in Cardiac Myocytes
- (2014) Christiane Neuber et al. PLoS One
- Protein Folding Activity of the Ribosome (PFAR) –– A Target for Antiprion Compounds
- (2014) Debapriya Banerjee et al. Viruses-Basel
- Changes in translation rate modulate stress-induced damage of diverse proteins
- (2013) Heejung Kim et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Structure of the Mammalian Ribosomal 43S Preinitiation Complex Bound to the Scanning Factor DHX29
- (2013) Yaser Hashem et al. CELL
- The Antiprion Compound 6-Aminophenanthridine Inhibits the Protein Folding Activity of the Ribosome by Direct Competition
- (2013) Yanhong Pang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation
- (2013) J. F. Abisambra et al. JOURNAL OF NEUROSCIENCE
- VPS35 and EIF4G1 mutations are rare in Parkinson's disease among Indians
- (2013) Sumedha Sudhaman et al. NEUROBIOLOGY OF AGING
- EIF4G1 R1205H and VPS35 D620N mutations are rare in Parkinson's disease from South Africa
- (2013) Janine Blanckenberg et al. NEUROBIOLOGY OF AGING
- Involvement of the immune system, endocytosis and EIF2 signaling in both genetically determined and sporadic forms of Parkinson's disease
- (2013) Eugénie Mutez et al. NEUROBIOLOGY OF DISEASE
- Translational control by eIF2α kinases in long-lasting synaptic plasticity and long-term memory
- (2013) Mimi A. Trinh et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors
- (2012) Yanjie Zhang et al. CELL CYCLE
- Autism-related deficits via dysregulated eIF4E-dependent translational control
- (2012) Christos G. Gkogkas et al. NATURE
- Sustained translational repression by eIF2α-P mediates prion neurodegeneration
- (2012) Julie A. Moreno et al. NATURE
- EIF4G1 in familial Parkinson's disease: pathogenic mutations or rare benign variants?
- (2012) Suzanne Lesage et al. NEUROBIOLOGY OF AGING
- VPS35 Asp620Asn and EIF4G1 Arg1205His mutations are rare in Parkinson disease from Southwest China
- (2012) YongPing Chen et al. NEUROBIOLOGY OF AGING
- Variants in eukaryotic translation initiation factor 4G1 in sporadic Parkinson’s disease
- (2012) Eva C. Schulte et al. NEUROGENETICS
- Study of the genetic variability in a Parkinson's Disease gene: EIF4G1
- (2012) Arianna Tucci et al. NEUROSCIENCE LETTERS
- Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor
- (2012) L M Lindqvist et al. Cell Death & Disease
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease
- (2011) Marie-Christine Chartier-Harlin et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Eukaryotic type translation initiation factor 2: Structure–functional aspects
- (2011) E. A. Stolboushkina et al. BIOCHEMISTRY-MOSCOW
- Eukaryotic elongation factor-2 (eEF2): its regulation and peptide chain elongation
- (2011) Gautam Kaul et al. CELL BIOCHEMISTRY AND FUNCTION
- Translational control by 80S formation and 60S availability: The central role of eIF6, a rate limiting factor in cell cycle progression and tumorigenesis
- (2011) Daniela Brina et al. CELL CYCLE
- Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy
- (2011) Nicolas Barbezier et al. EMBO Molecular Medicine
- Hepatitis C Virus NS5A Binds to the mRNA Cap-binding Eukaryotic Translation Initiation 4F (eIF4F) Complex and Up-regulates Host Translation Initiation Machinery through eIF4E-binding Protein 1 Inactivation
- (2011) Anju George et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR Signaling, Function, Novel Inhibitors, and Therapeutic Targets
- (2011) R. Watanabe et al. JOURNAL OF NUCLEAR MEDICINE
- ER stress response plays an important role in aggregation of α-synuclein
- (2011) Peizhou Jiang et al. Molecular Neurodegeneration
- Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis
- (2011) P. Tsaytler et al. SCIENCE
- Diminution of eIF4E activity suppresses parkin mutant phenotypes
- (2010) Cristina Ottone et al. GENE
- Stabilizing the eIF4G1 α-Helix Increases Its Binding Affinity with eIF4E: Implications for Peptidomimetic Design Strategies
- (2010) C.J. Brown et al. JOURNAL OF MOLECULAR BIOLOGY
- Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson’s disease
- (2010) Arianna Bellucci et al. JOURNAL OF NEUROCHEMISTRY
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease
- (2010) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G Interaction
- (2010) M. Shveygert et al. MOLECULAR AND CELLULAR BIOLOGY
- Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms
- (2010) Alexander Buchberger et al. MOLECULAR CELL
- The mechanism of eukaryotic translation initiation and principles of its regulation
- (2010) Richard J. Jackson et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTOR: from growth signal integration to cancer, diabetes and ageing
- (2010) Roberto Zoncu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets
- (2009) Nahum Sonenberg et al. CELL
- Mitochondrial dynamics in Parkinson's disease
- (2009) Victor S. Van Laar et al. EXPERIMENTAL NEUROLOGY
- Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss
- (2009) Luke S Tain et al. NATURE NEUROSCIENCE
- Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
- (2009) E. Santini et al. Science Signaling
- Depletion of the cap-associated isoform of translation factor eIF4G induces germline apoptosis in C. elegans
- (2008) V Contreras et al. CELL DEATH AND DIFFERENTIATION
- Dephosphorylation of Translation Initiation Factor 2α Enhances Glucose Tolerance and Attenuates Hepatosteatosis in Mice
- (2008) Seiichi Oyadomari et al. Cell Metabolism
- Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
- (2008) Yuzuru Imai et al. EMBO JOURNAL
- Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
- (2008) E. D. Smith et al. GENOME RESEARCH
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
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