Article
Biochemistry & Molecular Biology
Barbara Pesce, Carolina H. Ribeiro, Milton Larrondo, Veronica Ramos, Lilian Soto, Diego Catalan, Juan Carlos Aguillon
Summary: Tumor necrosis factor (TNF)-alpha regulates cytokine production by CD4+ T helper cells, and targeting TNFR2 may be an alternative strategy to normalize key cytokine levels that contribute to the pathogenesis of rheumatoid arthritis (RA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Irina Lousa, Luis Belo, Maria Joao Valente, Susana Rocha, Ines Preguica, Petronila Rocha-Pereira, Idalina Beirao, Filipe Mira, Rui Alves, Flavio Reis, Alice Santos-Silva
Summary: Inflammation plays an important role in chronic kidney disease (CKD). This study found that inflammatory biomarkers in the blood were associated with kidney function and injury parameters, and could potentially be used as early markers for diagnosis and staging of CKD.
INFLAMMATION RESEARCH
(2022)
Article
Immunology
Abrar Ul Haq Khan, Alaa Kassim Ali, Bryan Marr, Donghyeon Jo, Simin Ahmadvand, Claire Fong-McMaster, Saeedah Musaed Almutairi, Lisheng Wang, Subash Sad, Mary-Ellen Harper, Seung-Hwan Lee
Summary: Natural killer (NK) cells upregulate the expression of TNF receptor 2 (TNFR2) and CD25 in response to infection/inflammation, which enhances their proliferation, metabolic activity, and effector function. The TNFa-TNFR2 signaling pathway leads to a metabolic switch towards aerobic glycolysis and is crucial for NK cell function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Andy Ruiz, Yadira Palacios, Irene Garcia, Leslie Chavez-Galan
Summary: Tumor necrosis factor (TNF) is a key cytokine regulating inflammatory responses and plays a crucial role in granuloma formation during mycobacterial infections. The interactions between soluble and transmembrane TNF with their receptors influence effector mechanisms, providing insights into potential therapeutic strategies against mycobacterial infections. Understanding the structural and activation pathways of TNF and its receptors can offer valuable knowledge for developing more efficient therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mahsa Nouri Barkestani, Sara Shamdani, Mazdak Afshar Bakshloo, Nassim Arouche, Bijan Bambai, Georges Uzan, Sina Naserian
Summary: EPCs play a crucial role in angiogenesis and vascular regeneration. TNF alpha signaling pathway can significantly impact EPCs' immunological function, with TNF alpha-TNFR2 axis promoting anti-inflammatory effects. Pre-treating EPCs with TNF alpha can enhance their immunosuppressive phenotype and potentially improve their contribution to vascular repair.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Immunology
D. Alejandro Canaria, Bingyu Yan, Maia G. Clare, Zonghao Zhang, Grace A. Taylor, David L. Boone, Majid Kazemian, Matthew R. Olson
Summary: Th9 cells, which produce IL-9, have dual roles in immunity against parasites and cancers as well as in the pathogenesis of allergic diseases and colitis. The differentiation of Th9 cells is regulated by IL-2-induced STAT5 signaling, which is vital for chromatin accessibility within Il9 loci. In allergic disease, Th9 cells exhibit a gene repression signature associated with a Th17-like phenotype, suggesting a balance between these two T cell subsets controlled by IL-2/STAT5 signaling.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Shutong Li, Wenchuan Liu, Junze Liu, Zongcheng Yang, Liguo Zhang, Fujiao Nie, Pishan Yang, Hongmei Guo, Chengzhe Yang
Summary: The study assessed the role of the TNF-alpha/TNFR2 axis in promoting angiogenesis in oral squamous cell carcinoma (OSCC) cells and uncovered the mechanisms involved. The results showed that TNFR2 neutralizing antibody (TNFR2 Nab) could counteract the effects of TNF-alpha on OSCC cells through the TNFR2/Akt/mTOR axis, suggesting that blocking TNFR2 might be a promising strategy against cancer.
Article
Rheumatology
Takahito Suto, Anela Tosevska, Karolina Dalwigk, Maximillian Kugler, Mirjam Dellinger, Irena Stanic, Alexander Platzer, Birgit Niederreiter, Florian Sevelda, Michael Bonelli, Thomas Pap, Hans Kiener, Koichi Okamura, Hirotaka Chikuda, Daniel Aletaha, Leonhard X. Heinz, Thomas Karonitsch
Summary: This study identifies the critical role of TNFR2 in synovial inflammation in RA, highlighting its involvement in FLS-driven inflammation.
Article
Medicine, Research & Experimental
Wenyu Fu, Wenhuo Hu, Young-Su Yi, Aubryanna Hettinghouse, Guodong Sun, Yufei Bi, Wenjun He, Lei Zhang, Guanmin Gao, Jody Liu, Kazuhito Toyo-oka, Guozhi Xiao, David B. Solit, Png Loke, Chuan-ju Liu
Summary: This study identified 14-3-3c as a crucial component of the TNFR2 receptor complex, playing a key role in regulating macrophage polarization and anti-inflammatory effects. Deletion of 14-3-3c exacerbated inflammatory arthritis and counteracted the protective effects of TNFR2 activation against inflammation and autoimmunity. TNFR2/14-3-3c signaling pathway restricts NF-KB activation while stimulating C/EBPp activation, influencing macrophage plasticity.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Juan Gamboa Vargas, Jennifer Wagner, Haroon Shaikh, Isabell Lang, Juliane Medler, Mohamed Anany, Tim Steinfatt, Josefina Pena Mosca, Stephanie Haack, Julia Dahlhoff, Maike Buettner-Herold, Carolin Graf, Estibaliz Arellano Viera, Hermann Einsele, Harald Wajant, Andreas Beilhack
Summary: In this study, a new fusion protein called NewSTAR2 was developed with improved serum retention and superior in vivo activity, showing powerful protective effects against acute GvHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Haritha L. Desu, Placido Illiano, James S. Choi, Maureen C. Ascona, Han Gao, Jae K. Lee, Roberta Brambilla
Summary: The study reveals that neuroinflammation in multiple sclerosis leads to a shift in oligodendrocyte precursor cells (OPCs) towards an immunomodulatory phenotype, reducing their remyelination capacity and impairing their repair function. Furthermore, enhancing TNFR2 activation could be an effective strategy to restore OPC reparative capacity.
Review
Oncology
Juliane Medler, Kirstin Kucka, Harald Wajant
Summary: Tumor necrosis factor receptor-2 (TNFR2) affects tumor development and metastasis in various ways, functioning as both an immune suppressor and an anti-tumoral agent. The potential of TNFR2 antagonists and agonists as tumor therapy is currently being studied, along with the underlying mechanisms of TNFR2 in tumor biology.
Article
Immunology
Aran Son, Francoise Meylan, Julio Gomez-Rodriguez, Zenia Kaul, McKella Sylvester, Guido H. Falduto, Estefania Vazquez, Tamara Haque, Moses M. Kitakule, Chujun Wang, Kalpana Manthiram, Chen-Feng Qi, Jun Cheng, Rama K. Gurram, Jinfang Zhu, Pamela Schwartzberg, Joshua D. Milner, Pamela A. Frischmeyer-Guerrerio, Daniella M. Schwartz
Summary: Schwartz and colleagues found that T(H)9 cells can induce the expression of IL-9 independently through bystander activation by IL-2 and IL-4, promoting allergic inflammation. Targeting the STAT5/STAT6 activation cascade may provide relief for chronic allergy patients. Allergic diseases are a global health issue, and T(H)9 cells play a role in promoting allergic inflammation, but their exact mechanisms are not fully understood.
Review
Biochemistry & Molecular Biology
Nurul Hakimah Mohd Salim, Ali Mussa, Naveed Ahmed, Suhana Ahmad, Chan Yean Yean, Rosline Hassan, Vuk Uskokovic, Rohimah Mohamud, Nur Asyilla Che Jalil
Summary: Colorectal cancer is a common cause of cancer-related deaths globally, with increasing incidence among young individuals. The tumor microenvironment in colorectal cancer is highly heterogeneous and immunosuppressive. Tumor necrosis factors (TNFs) and TNF receptor 2 (TNFR2) play critical roles in the development of colorectal cancer by enhancing the immunosuppressive activity of cancer cells. However, the exact mechanism of TNFR2 in regulating colorectal cancer prognosis is still unclear. Further studies on TNFR2 downstream signaling are needed to unlock its potential as a therapeutic agent and cancer biomarker.
Article
Immunology
Tianzhen He, Yi Zhao, Peng Zhao, Liwen Zhao, Jaffry Zakaria, Ke Wang
Summary: TNFR2, preferentially expressed by Tregs, is a significant surface marker for the activation and expansion of Tregs. There are three required signaling pathways for the inhibitory effect of Tregs, including NF-κB, MAPK, and PI3K-Akt pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)