期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 108, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.intimp.2022.108823
关键词
Tregs; TNF; TNFR2; Signaling pathway
资金
- Science Foundation of Nantong [jc2021018]
- National Natural Science Foundation of China (NSFC) [82100557]
TNFR2, preferentially expressed by Tregs, is a significant surface marker for the activation and expansion of Tregs. There are three required signaling pathways for the inhibitory effect of Tregs, including NF-κB, MAPK, and PI3K-Akt pathways.
CD4+Foxp3+ regulatory T cells (Tregs), a subpopulation of CD4+ T cells, are engaged in maintaining the periphery tolerance and preventing autoimmunity. Recent studies showed that tumor necrosis factor receptor 2 (TNFR2) is preferentially expressed by Tregs and the expression of this receptor identifies the maximally suppressive Tregs. That is, TNFR2 is a liable phenotypic and functional surface marker of Tregs. Moreover, TNF activates and expands Tregs through TNFR2. However, it is very interesting which signaling pathway(s) of TNFR2 is required for the inhibitory effect of Tregs. Compelling evidence shows three TNFR2 signaling pathways in Tregs, including NF-KB, MAPK and PI3K-Akt pathways. Here, we summarize and discuss the latest progress in the studies on the downstream signaling pathways of TNF-TNFR2 for controlling Treg homeostasis, differentiation and proliferation.
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