Live-Imaging Readouts and Cell Models for Phenotypic Profiling of Mitochondrial Function

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases

(2018) Gerwyn Morris et al.   BEHAVIOURAL BRAIN RESEARCH

Toward Precision Medicine for Neurological and Neuropsychiatric Disorders

(2018) Rebecca M. Gibbs et al.   Cell Stem Cell

Mitochondria and the dynamic control of stem cell homeostasis

(2018) Pawel Lisowski et al.   EMBO REPORTS

Lipid-mediated signals that regulate mitochondrial biology

(2018) Jason R. Nielson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

(2018) Matheus B. Victor et al.   NATURE NEUROSCIENCE

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized

(2018) Payam A. Gammage et al.   TRENDS IN GENETICS

A single cell high content assay detects mitochondrial dysfunction in iPSC-derived neurons with mutations in SNCA

(2018) Daniel Little et al.   Scientific Reports

Extracellular acidification induces ROS- and mPTP-mediated death in HEK293 cells

(2018) José Teixeira et al.   Redox Biology

Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases

(2018) Jerome Mertens et al.   Annual Review of Genetics

KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery

(2018) Julien Beyrath et al.   Scientific Reports

Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD+

(2018) Eligio F. Iannetti et al.   Cell Death & Disease

Oxygen imaging of living cells and tissues using luminescent molecular probes

(2017) Toshitada Yoshihara et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS

Concise Review: Induced Pluripotent Stem Cell-Based Drug Discovery for Mitochondrial Disease

(2017) Gizem Inak et al.   STEM CELLS

High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease

(2017) Gianluca Pegoraro et al.   TRENDS IN GENETICS

Mitochondrial respiratory dysfunction disturbs neuronal and cardiac lineage commitment of human iPSCs

(2017) Mutsumi Yokota et al.   Cell Death & Disease

Detection of ROS Induced Proteomic Signatures by Mass Spectrometry

(2017) Brian McDonagh   Frontiers in Physiology

Rhodamine-Based Fluorescent Turn-On Probe for Facile Sensing and Imaging of ATP in Mitochondria

(2017) Omprakash Sunnapu et al.   ChemistrySelect

HyPer Family Probes: State of the Art

(2016) Dmitry S. Bilan et al.   ANTIOXIDANTS & REDOX SIGNALING

Imaging Adenosine Triphosphate (ATP)

(2016) Megha Rajendran et al.   BIOLOGICAL BULLETIN

Modifying the Mitochondrial Genome

(2016) Alexander N. Patananan et al.   Cell Metabolism

Natural underlying mtDNA heteroplasmy as a potential source of intra‐person hiPSC variability

(2016) Ester Perales‐Clemente et al.   EMBO JOURNAL

Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy

(2016) Eligio F Iannetti et al.   Nature Protocols

Measurement of the Absolute Magnitude and Time Courses of Mitochondrial Membrane Potential in Primary and Clonal Pancreatic Beta-Cells

(2016) Akos A. Gerencser et al.   PLoS One

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Mitochondria-Targeted Green Fluorescent Protein for Quantitative Monitoring of Mitochondrial Morphology in Living Cells

(2016) Yasutomo Nomura et al.   Letters in Drug Design & Discovery

BTeam, a Novel BRET-based Biosensor for the Accurate Quantification of ATP Concentration within Living Cells

(2016) Tomoki Yoshida et al.   Scientific Reports

Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning

(2015) Anthony P. Leonard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition

(2015) Tom J.J. Schirris et al.   Cell Metabolism

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Imaging mitochondrial reactive oxygen species with fluorescent probes: Current applications and challenges

(2015) X. Zhang et al.   FREE RADICAL RESEARCH

Mitochondrial respiratory dysfunction caused by a heteroplasmic mitochondrial DNA mutation blocks cellular reprogramming

(2015) Mutsumi Yokota et al.   HUMAN MOLECULAR GENETICS

Toward high-content screening of mitochondrial morphology and membrane potential in living cells

(2015) Eligio F. Iannetti et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Generation of Isogenic Human iPS Cell Line Precisely Corrected by Genome Editing Using the CRISPR/Cas9 System

(2015) Benjamin Grobarczyk et al.   Stem Cell Reviews and Reports

Generation of Isogenic Human iPS Cell Line Precisely Corrected by Genome Editing Using the CRISPR/Cas9 System

(2015) Benjamin Grobarczyk et al.   Stem Cell Reviews and Reports

Intracellular probes for imaging oxygen concentration: how good are they?

(2015) Ruslan I Dmitriev et al.   Methods and Applications in Fluorescence

Molecular pathomechanisms and cell-type-specific disease phenotypes of MELAS caused by mutant mitochondrial tRNATrp

(2015) Hideyuki Hatakeyama et al.   Acta Neuropathologica Communications

Mitochondrial hyperpolarization during chronic complex I inhibition is sustained by low activity of complex II, III, IV and V

(2014) Marleen Forkink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Genetically encoded reactive oxygen species (ROS) and redox indicators

(2014) Sandrine Pouvreau   Biotechnology Journal

Diagnosis and management of mitochondrial disease: a consensus statement from the Mitochondrial Medicine Society

(2014) Sumit Parikh et al.   GENETICS IN MEDICINE

Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies

(2014) Heather M. Wilkins et al.   Redox Biology

The broadening spectrum of mitochondrial disease: Shifts in the diagnostic paradigm

(2013) Christina Liang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cellular and animal models for mitochondrial complex I deficiency: A focus on the NDUFS4 subunit

(2013) Megan E. Breuer et al.   IUBMB LIFE

Disease-Causing Mitochondrial Heteroplasmy Segregated Within Induced Pluripotent Stem Cell Clones Derived from a Patient with MELAS

(2013) Clifford D.L. Folmes et al.   STEM CELLS

Mitochondria as a Target of Environmental Toxicants

(2013) Joel N. Meyer et al.   TOXICOLOGICAL SCIENCES

Recent advances in reactive oxygen species measurement in biological systems

(2013) J.F. Woolley et al.   TRENDS IN BIOCHEMICAL SCIENCES

A high content screening assay to predict human drug-induced liver injury during drug discovery

(2013) Mikael Persson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

A ratiometric fluorescent probe for assessing mitochondrial phospholipid peroxidation within living cells

(2012) Tracy A. Prime et al.   FREE RADICAL BIOLOGY AND MEDICINE

Primary Skin Fibroblasts as a Model of Parkinson's Disease

(2012) Georg Auburger et al.   MOLECULAR NEUROBIOLOGY

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging

(2011) William D. Shrader et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Mitochondria: isolation, structure and function

(2011) Martin Picard et al.   JOURNAL OF PHYSIOLOGY-LONDON

Quantitative Glucose and ATP Sensing in Mammalian Cells

(2011) Dania C. Liemburg-Apers et al.   PHARMACEUTICAL RESEARCH

Mammalian cell transfection: the present and the future

(2010) Tae Kyung Kim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Fluorescent Protein-Based Redox Probes

(2010) Andreas J. Meyer et al.   ANTIOXIDANTS & REDOX SIGNALING

Multi-site control and regulation of mitochondrial energy production

(2010) G. Benard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Detection and manipulation of mitochondrial reactive oxygen species in mammalian cells

(2010) Marleen Forkink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mechanism of neurodegeneration of neurons with mitochondrial DNA mutations

(2010) A. Y. Abramov et al.   BRAIN

Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: Another inconvenient truth

(2010) Jacek Zielonka et al.   FREE RADICAL BIOLOGY AND MEDICINE

2′,7′-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: Forty years of application and controversy

(2010) Xiuping Chen et al.   FREE RADICAL RESEARCH

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

High content screening: seeing is believing

(2010) Fabian Zanella et al.   TRENDS IN BIOTECHNOLOGY

Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators

(2009) H. Imamura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Computer-assisted live cell analysis of mitochondrial membrane potential, morphology and calcium handling

(2008) Werner J.H. Koopman et al.   METHODS