Article
Biochemistry & Molecular Biology
Amandine Rovini, Kareem Heslop, Elizabeth G. Hunt, Morgan E. Morris, Diana Fang, Monika Gooz, Akos A. Gerencser, Eduardo N. Maldonado
Summary: The study quantified intercellular differences in Delta psi m in human cancer cells and fibroblasts, showing that Delta psi m is more heterogeneous in cancer cells and maintained throughout the cell cycle. The effect of chemical inhibition of the respiratory chain and ATP synthesis varied between cells with different levels of Delta psi m.
Article
Engineering, Aerospace
Emilia Georgiana Prisacariu, Tudor Prisecaru, Razvan Edmond Nicoara, Jeni Vilag, Valeriu Alexandru Vilag
Summary: Visualization methods, such as Schlieren image velocimetry (SIV), are used to inspect invisible flows, and seedless velocimetry has found applications in various industries. In this study, a micro-thruster generating a turbulent exhaust jet is analyzed using SIV and compared with CFD simulation results to evaluate its performance. By mapping local velocities through a lagrangian tracking method, SIV can determine if the thruster reaches the desired Mach.
Article
Mathematics, Interdisciplinary Applications
Bogdan Popa, Dan Selisteanu, Alexandra Elisabeta Lorincz
Summary: This article introduces a specific model for fractal generation and analyzes its efficiency and the generated graphic results from a programming perspective. The paper presents the software structure and implementation of the model and provides comparisons and demonstrations related to calculation times. The use of parallel programming is highlighted to emphasize methods of speeding up computing times.
FRACTAL AND FRACTIONAL
(2022)
Article
Computer Science, Artificial Intelligence
Zhen Li, Xinjiang Ye, Huawei Liang
Summary: This paper builds a sports video analysis system based on image recognition technology, which comprehensively analyzes dynamic images using various techniques to improve the data fusion effect, as well as designs a dynamic image analysis method to enhance the quality of the fused dynamic images.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Chemistry, Physical
Pei Sun, Ke Zhang, Sen Han, Zijun Liang, Wei Kong, Xuejuan Zhan
Summary: The homogeneity of asphalt mixture can be evaluated quantitatively using digital image processing technique combined with stereology theory. Decreasing the aggregate size and improving the aggregate gradation can enhance the homogeneity of the asphalt mixture. Controlling the asphalt content can optimize the homogeneity of the internal structure of the asphalt mixture.
Article
Automation & Control Systems
Yanyi Liu, Chen Wang, Yingyou Wen, Yixiang Huo, Jun Liu
Summary: The cellular image analysis system is crucial for disease diagnosis and pharmaceutical research. However, due to the differences in cellular image distribution, the analysis requires customized algorithms and parameter tuning, leading to low automation levels. This study proposes an efficient end-to-end cell segmentation algorithm, ECS-Net, which introduces the proposal focus module (PFM) and enhance mask feature head (EMFH) to improve segmentation accuracy. The algorithm achieves better detection and segmentation accuracy with fewer parameters and computational cost, enhancing cellular image analysis systems. Moreover, considering the medical IoT scenario, the scaled-down model with only 5.8M parameters has a minor decrease in accuracy, but significant application value.
IET CONTROL THEORY AND APPLICATIONS
(2023)
Article
Chemistry, Analytical
Piotr Bogacki, Andrzej Dziech
Summary: The paper focuses on the application of new orthogonal transforms in digital watermarking. It presents novel types of transforms and proposes potential methods for watermark embedding and recovery. The methods were evaluated based on visual distortion and bit error rate, highlighting their usefulness in digital signal and image processing.
Article
Agronomy
Hong Gu Lee, Min-Jee Kim, Su-bae Kim, Sujin Lee, Hoyoung Lee, Jeong Yong Sin, Changyeun Mo
Summary: This study proposes an image-processing method to enhance the detection performance of bee mites and verifies its effectiveness through the analysis of keypoints. The results show that diverse image-processing techniques significantly improve the quality of bee mite detection and can be used in conjunction with a deep-learning algorithm to monitor bee mites and diseases.
Review
Biology
Runze Chen, Min Liu, Weixun Chen, Yaonan Wang, Erik Meijering
Summary: This article reviews the applications of deep learning algorithms in brain mesoscale microscopy image processing and analysis, including image synthesis, segmentation, object detection, and neuron reconstruction and analysis. These algorithms perform exceptionally well in handling complex brain images and provide possibilities for further research directions.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Mathematics
Jesus Jaime Moreno Escobar, Erika Yolanda Aguilar del Villar, Oswaldo Morales Matamoros, Liliana Chanona Hernandez
Summary: This work consists of three parts: (i) development of a methodology for building a 3D/stereoscopic database, (ii) design of a software tool for degrading 3D/stereoscopic images, and (iii) conducting a psychophysical experiment on a specific type of noise. The integration of these three parts is the novelty of this work, providing assistance to professionals in estimating three-dimensional image quality and generating new image databases.
Review
Oncology
Peter Bankhead
Summary: The potential of quantitative image analysis and artificial intelligence in digital pathology is highlighted. However, the lack of available software and the complexity of existing methods hinder widespread adoption. This review emphasizes the need for collaboration and multidisciplinary approaches in developing new algorithms and calls for greater attention to openness, implementation, and usability. The interaction between digital pathology and the bioimage analysis community is seen as beneficial in terms of data sharing and idea exchange.
JOURNAL OF PATHOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Ozguer Yurtsever, Haluk Kucuk
Summary: In this study, a 2-DOF soft robotic arm for medical interventional applications was developed, which utilizes a Flexinol® Shape Memory Material (SMA) wire based actuation mechanism controlled wirelessly. The arm consists of a body, joint, and a micro gripper end-effector sections. The influence of pulse width modulation (PWM) on the neck motion range and actuation speed was quantified using Matlab Image processing toolbox. An algorithm was developed to track the neck boundary and estimate the angular deviation. The gripping force of the arm was assessed using a load cell measurement module.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Ecology
Tianyu Xi, Jiangning Wang, Huijie Qiao, Congtian Lin, Liqiang Ji
Summary: A study developed an Image Filtering and Labelling Assistant system to assist biology/ecology researchers in expediting the selection and labelling of field monitoring images, improving efficiency and accuracy.
ECOLOGICAL INFORMATICS
(2021)
Article
Engineering, Mechanical
Alizee Bouchot, Amandine Ferrieux, Johan Debayle, Guilhem Mollon, Sylvie Descartes
Summary: The study enriches the quantification of the rheology of the tribological interface through advanced image processing, including the study of traditional descriptors and new relevant descriptors. This approach shows promising results in understanding the mechanisms involved in dry contacts.
Article
Neurosciences
Hao Guan, Mingxia Liu
Summary: Domain adaptation is an important technique in machine learning-based medical data analysis to reduce distribution differences between different datasets. The Domain Adaptation Toolbox for Medical data analysis (DomainATM) is an open-source software package implemented in MATLAB, offering a collection of popular data adaptation algorithms for medical image analysis. It provides researchers with the capability to perform fast feature-level and image-level adaptation, visualization, and performance evaluation of adaptation methods. Users can also develop and test their own adaptation methods through scripting, enhancing the utility and extensibility of DomainATM. The software, source code, and manual are available online.
Article
Sport Sciences
Yvonne A. W. Hartman, Laura C. M. Tillmans, David L. Benschop, Astrid N. L. Hermans, Kevin M. R. Nijssen, Thijs M. H. Eijsvogels, Peter H. G. M. Willems, Cees J. Tack, Maria T. E. Hopman, Jurgen A. H. R. Claassen, Dick H. J. Thijssen
Summary: Long-term reduction in sedentary behavior improves peripheral vascular function and cerebral blood flow, and acutely prevents impaired vascular function and decreased cerebral blood flow. These results highlight the potential benefits of reducing sedentary behavior to acutely and chronically improve cardio- or cerebrovascular risk.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Correction
Biochemistry & Molecular Biology
Sjoerd Verkaart, Werner J. H. Koopman, Sjenet E. van Emst-de Vries, Leo G. J. Nijtmans, Lambertus W. P. J. van den Heuvel, Jan A. M. Smeitink, Peter H. G. M. Willems
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Correction
Biochemistry & Molecular Biology
S. Verkaart, W. J. Koopman, J. Cheek, S. E. van Emst-de Vries, L. W. van den Heuvel, J. A. Smeitink, P. H. Willems
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jose Teixeira, Farhan Basit, Peter H. G. M. Willems, Jori A. Wagenaars, Els van de Westerlo, Ricardo Amorim, Fernando Cagide, Sofia Benfeito, Catarina Oliveira, Fernanda Borges, Paulo J. Oliveira, Werner J. H. Koopman
Summary: The novel mitochondria-targeted variants of gallic and caffeic acid were found to increase ROS levels, stimulate NRF2 expression, and increase SOD2 and GSH levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Clinical Neurology
Melissa A. E. van de Wal, Merel J. W. Adjobo-Hermans, Jaap Keijer, Tom J. J. Schirris, Judith R. Homberg, Mariusz R. Wieckowski, Sander Grefte, Evert M. van Schothorst, Clara van Karnebeek, Albert Quintana, Werner J. H. Koopman
Summary: Mitochondrial dysfunction is associated with various syndromes and diseases, including Leigh syndrome. Mutations in the NDUFS4 gene can cause Leigh syndrome, and studying it in mouse models has provided new insights into the pathomechanism and treatment.
Review
Cell Biology
Sandeep Chenna, Werner J. H. Koopman, Jochen H. M. Prehn, Niamh M. C. Connolly
Summary: This article discusses the mechanistic models and minimal models of mitochondrial reactive oxygen species (ROS) homeostasis. Mechanistic models provide valuable insights but are complex, while minimal models use a smaller set of equations to describe empirical relationships and generate hypotheses. Finally, the article illustrates the application of minimal models in studying the pathophysiology of ROS.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elianne P. Bulthuis, Claudia Einer, Felix Distelmaier, Laszlo Groh, Sjenet E. Van Emst-De Vries, Els Van De Westerlo, Melissa Van De Wal, Jori Wagenaars, Richard J. Rodenburg, Jan A. M. Smeitink, Niels P. Riksen, Peter H. G. M. Willems, Merel J. W. Adjobo-Hermans, Hans Zischka, Werner J. H. Koopman
Summary: The study showed that targeted molecules for mitochondria can lead to decreased levels of mitochondrial complex I, reduced ETC supercomplexes, inhibition of mitochondrial oxygen consumption, increased extracellular acidification, altered mitochondrial morphology, and stimulated hydroethidine oxidation. The research highlights the impact of mitochondria-targeting moieties on cellular functions.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Elianne P. Bulthuis, Cindy E. J. Dieteren, Jesper Bergmans, Job Berkhout, Jori A. Wagenaars, Els M. A. van de Westerlo, Emina Podhumljak, Mark A. Hink, Laura F. B. Hesp, Hannah S. Rosa, Afshan N. Malik, Mariska te Lindert, Peter H. G. M. Willems, Wouter den Otter, Han J. G. E. Gardeniers, Merel J. W. Adjobo-Hermans, Werner J. H. Koopman
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2022)
Article
Microbiology
Samara Rosendo Machado, Jieqiong Qu, Werner J. H. Koopman, Pascal Miesen
Summary: This study discovered the important role of Dhx15 gene and the glycolysis pathway it regulates in controlling mosquito infection by arboviruses, providing a new perspective on the molecular interactions between arboviruses and their mosquito hosts.
Article
Toxicology
Charlotte A. Hoogstraten, Maaike M. E. Jacobs, Guido de Boer, Melissa A. E. van de Wal, Werner J. H. Koopman, Jan A. M. Smeitink, Frans G. M. Russel, Tom J. J. Schirris
Summary: Mitochondrial dysfunction plays a pivotal role in drug-induced acute kidney injury (AKI) and the transport protein AAC is an important potential drug off-target. In this study, AAC3 deficiency led to reduced mitochondrial function and mass in human renal proximal tubular cells, particularly affecting metabolic spare capacity under galactose conditions.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elianne P. Bulthuis, Cindy E. J. Dieteren, Jesper Bergmans, Job Berkhout, Jori A. Wagenaars, Els M. A. van de Westerlo, Emina Podhumljak, Mark A. Hink, Laura F. B. Hesp, Hannah S. Rosa, Afshan N. Malik, Mariska Kea-te Lindert, Peter H. G. M. Willems, Han J. G. E. Gardeniers, Wouter K. den Otter, Merel J. W. Adjobo-Hermans, Werner J. H. Koopman
Summary: Macromolecules of various sizes induce crowding in the cellular environment, which affects biochemical reactions by altering solvent viscosity, water-accessible volume, and protein properties. This study shows that the mitochondrial matrix solvent exhibits macromolecular crowding, as demonstrated by the elongated molecular structure of fluorescent protein fusion peptides and decreased diffusion constant with increasing molecular weight. Chloramphenicol treatment impairs mitochondrial function and increases matrix viscosity, indicating increased macromolecular crowding. These findings highlight the importance of matrix crowding in mitochondria and suggest that changes in crowding conditions can impact biochemical reactions.
Article
Biochemistry & Molecular Biology
Federica Conte, Angel Ashikov, Rachel Mijdam, Eline G. P. van de Ven, Monique van Scherpenzeel, Raisa Veizaj, Seyed P. Mahalleh-Yousefi, Merel A. Post, Karin Huijben, Daan M. Panneman, Richard J. T. Rodenburg, Nicol C. Voermans, Alejandro Garanto, Werner J. H. Koopman, Hans J. C. T. Wessels, Marek J. Noga, Dirk J. Lefeber
Summary: Phosphoglucomutase 1 (PGM1) is a key enzyme involved in energy metabolism and its deficiency causes a wide range of symptoms. D-galactose supplementation has been shown to improve some symptoms, but its effects on skeletal muscle and heart remain unclear. In this study, a muscle cell model for PGM1 deficiency was established, which revealed that D-galactose failed to restore the reduced energy production capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Meeting Abstract
Medicine, General & Internal
D. W. J. H. Koopman
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemical Research Methods
K. Ramki, G. Thiruppathi, Selva Kumar Ramasamy, P. Sundararaj, P. Sakthivel
Summary: A chromone-based ratiometric fluorescent probe L2 was developed for the selective detection of Hg(II) in a semiaqueous solution. The probe exhibited enhanced fluorescence in its aggregated state and even higher fluorescence when chelated with Hg(II). The probe demonstrated high sensitivity and specificity for Hg(II) detection and was successfully applied for imaging Hg(II) in a living model.
Article
Biochemical Research Methods
Qun Zhang, Rui Yang, Gang Liu, Shiyan Jiang, Jiarui Wang, Juqiang Lin, Tingyin Wang, Jing Wang, Zufang Huang
Summary: This research aims to develop a cost-effective and portable method for measuring creatinine levels using the enhanced Tyndall effect phenomenon. The method offers a promising solution for monitoring renal healthcare in resource-limited settings.