Do Th17 Lymphocytes and IL-17 Contribute to Parkinson's Disease? A Systematic Review of Available Evidence

Mutant LRRK2 mediates peripheral and central immune responses leading to neurodegeneration in vivo

(2018) Elena Kozina et al.   BRAIN

Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease

(2018) Annika Sommer et al.   Cell Stem Cell

Monoclonal Antibodies Targeting the IL-17/IL-17RA Axis: An Opportunity to Improve the Efficiency of Anti-VEGF Therapy in Fighting Metastatic Colorectal Cancer?

(2018) Sajida Ibrahim et al.   Clinical Colorectal Cancer

Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients

(2018) Natasa Kustrimovic et al.   Journal of Neuroinflammation

Inflammatory bowel disease and risk of Parkinson's disease in Medicare beneficiaries

(2018) Alejandra Camacho-Soto et al.   PARKINSONISM & RELATED DISORDERS

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

(2018) Yulan Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti–Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease

(2018) Inga Peter et al.   JAMA Neurology

Imbalance of Circulating Th17 and Regulatory T Cells in Alzheimer’s Disease: A Case Control Study

(2018) Timo Jan Oberstein et al.   Frontiers in Immunology

Neuroinflammation and Peripheral Immune Infiltration in Parkinson's Disease: An Autoimmune Hypothesis

(2018) Angela J. Monahan et al.   CELL TRANSPLANTATION

The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6

(2018) Isak W. Tengesdal et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The immune response to Prevotella bacteria in chronic inflammatory disease

(2017) Jeppe Madura Larsen   IMMUNOLOGY

Parkinson disease–associatedLRRK2 G2019Stransgene disrupts marrow myelopoiesis and peripheral Th17 response

(2017) Jeongho Park et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

Dopaminergic Regulation of Innate Immunity: a Review

(2017) Monica Pinoli et al.   Journal of Neuroimmune Pharmacology

Interactions between the microbiota, immune and nervous systems in health and disease

(2017) Thomas C Fung et al.   NATURE NEUROSCIENCE

The correlation of lymphocyte subsets, natural killer cell, and Parkinson’s disease: a meta-analysis

(2017) Sen Jiang et al.   NEUROLOGICAL SCIENCES

Increased abundance of myeloid-derived suppressor cells and Th17 cells in peripheral blood of newly-diagnosed Parkinson’s disease patients

(2017) Siyuan Chen et al.   NEUROSCIENCE LETTERS

The role of Th17 cells in auto-inflammatory neurological disorders

(2017) Foozhan Tahmasebinia et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Microglial phenotypes in Parkinson’s disease and animal models of the disease

(2017) Valerie Joers et al.   PROGRESS IN NEUROBIOLOGY

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

(2017) Heather D.E. Booth et al.   TRENDS IN NEUROSCIENCES

Peripheral Lymphocyte Subsets as a Marker of Parkinson’s Disease in a Chinese Population

(2017) Luan Cen et al.   Neuroscience Bulletin

Increased Levels of Pro-Inflammatory and Anti-Inflammatory Cellular Responses in Parkinson’s Disease Patients: Search for a Disease Indicator

(2017) Likun Yang et al.   MEDICAL SCIENCE MONITOR

Parallel assessment of Th17 cell frequencies by surface marker co-expression versus ex vivo IL-17 production in HIV-1 infection

(2016) Gábor A. Dunay et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

The role of dopamine in modulation of Th-17 immune response in multiple sclerosis

(2016) Mikhail Melnikov et al.   JOURNAL OF NEUROIMMUNOLOGY

Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study

(2016) Eva Havrdová et al.   JOURNAL OF NEUROLOGY

Reduced Risk of Parkinson Disease in Patients With Rheumatoid Arthritis

(2016) Yueh-Feng Sung et al.   MAYO CLINIC PROCEEDINGS

Th17 Cells Induce Dopaminergic Neuronal Death via LFA-1/ICAM-1 Interaction in a Mouse Model of Parkinson’s Disease

(2016) Zhan Liu et al.   MOLECULAR NEUROBIOLOGY

Unmasking levodopa resistance in Parkinson's disease

(2016) Jorik Nonnekes et al.   MOVEMENT DISORDERS

Systematic Review of the Relationship between Vitamin D and Parkinson’s Disease

(2016) Lisanne M. Rimmelzwaan et al.   Journal of Parkinsons Disease

Risk of Parkinson's disease among patients with psoriasis: A systematic review and meta-analysis

(2016) Patompong Ungprasert et al.   INDIAN JOURNAL OF DERMATOLOGY

Dopaminergic Receptors on CD4+ T Naive and Memory Lymphocytes Correlate with Motor Impairment in Patients with Parkinson’s Disease

(2016) Natasa Kustrimovic et al.   Scientific Reports

The role of IL-17 in CNS diseases

(2015) Ari Waisman et al.   ACTA NEUROPATHOLOGICA

Group 3 innate lymphoid cells accumulate and exhibit disease-induced activation in the meninges in EAE

(2015) Julianne K. Hatfield et al.   CELLULAR IMMUNOLOGY

Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells

(2015) Hugo González et al.   Journal of Neuroimmune Pharmacology

Multiple Sclerosis and T Lymphocytes: An Entangled Story

(2015) Laurine Legroux et al.   Journal of Neuroimmune Pharmacology

IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation

(2015) Jie Sun et al.   Journal of Neuroinflammation

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations

(2015) Benjamin Dehay et al.   LANCET NEUROLOGY

Advances in T Helper 17 Cell Biology: Pathogenic Role and Potential Therapy in Multiple Sclerosis

(2015) Elisabetta Volpe et al.   MEDIATORS OF INFLAMMATION

Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation

(2015) Katja Derkow et al.   PLoS One

Vitamin D and 1,25(OH)2D Regulation of T cells

(2015) Margherita Cantorna et al.   Nutrients

Dopamine favors expansion of glucocorticoid-resistant IL-17-producing T cells in multiple sclerosis

(2014) Thais B. Ferreira et al.   BRAIN BEHAVIOR AND IMMUNITY

Th17 plasticity: pathophysiology and treatment of chronic inflammatory disorders

(2014) Lorenzo Cosmi et al.   CURRENT OPINION IN PHARMACOLOGY

Gut Inflammation: Current Update on Pathophysiology, Molecular Mechanism and Pharmacological Treatment Modalities

(2014) Klara Gyires et al.   CURRENT PHARMACEUTICAL DESIGN

Pharmacological Treatment of Parkinson Disease

(2014) Barbara S. Connolly et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Simvastatin Inhibits IL-17 Secretion by Targeting Multiple IL-17-Regulatory Cytokines and by Inhibiting the Expression of IL-17 Transcription Factor RORC in CD4+ Lymphocytes

(2014) X. Zhang et al.   JOURNAL OF IMMUNOLOGY

IL-17 Promotes Murine Lupus

(2014) Gil Amarilyo et al.   JOURNAL OF IMMUNOLOGY

Changes in Th17 and regulatory T cells after fingolimod initiation to treat multiple sclerosis

(2014) Douglas Kazutoshi Sato et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases

(2014) Hugo González et al.   JOURNAL OF NEUROIMMUNOLOGY

LRRK2 and neuroinflammation: partners in crime in Parkinson’s disease?

(2014) Isabella Russo et al.   Journal of Neuroinflammation

T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases

(2014) Hugo González et al.   Journal of Neuroinflammation

A review of vitamin D and Parkinson's disease

(2014) Amie L. Peterson   MATURITAS

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Targeting Th17 cells in autoimmune diseases

(2014) Jianfei Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

Th17 Cells in Cancer: The Ultimate Identity Crisis

(2014) Stefanie R. Bailey et al.   Frontiers in Immunology

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

(2013) David Moher   ANNALS OF INTERNAL MEDICINE

T helper-17 activation dominates the immunologic milieu of both amyotrophic lateral sclerosis and progressive multiple sclerosis

(2013) Marina Saresella et al.   CLINICAL IMMUNOLOGY

OMIP-017: Human CD4+helper T-cell subsets including follicular helper cells

(2013) Yolanda D. Mahnke et al.   CYTOMETRY PART A

T helper cells plasticity in inflammation

(2013) Lorenzo Cosmi et al.   CYTOMETRY PART A

Non-dopaminergic Treatments for Motor Control in Parkinson’s Disease

(2013) Susan H. Fox   DRUGS

Th17 cell development: from the cradle to the grave

(2013) Luis A. Zúñiga et al.   IMMUNOLOGICAL REVIEWS

Immunotherapy of allergic diseases using probiotics or recombinant probiotics

(2013) M.S.P. de Azevedo et al.   JOURNAL OF APPLIED MICROBIOLOGY

Analysis of Plasma Multiplex Cytokines for Children With Febrile Seizures and Severe Acute Encephalitis

(2013) Mei-Hua Hu et al.   JOURNAL OF CHILD NEUROLOGY

Cellular and Molecular Mediators of Neuroinflammation in the Pathogenesis of Parkinson’s Disease

(2013) Sandeep Vasant More et al.   MEDIATORS OF INFLAMMATION

Intracellular cytokine detection by fluorescence-activated flow cytometry: Basic principles and recent advances

(2013) Giulia Freer et al.   METHODS

An economic model of Parkinson's disease: Implications for slowing progression in the United States

(2013) Scott J. Johnson et al.   MOVEMENT DISORDERS

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

Th17 Cell-Mediated Neuroinflammation Is Involved in Neurodegeneration of Aβ1-42-Induced Alzheimer’s Disease Model Rats

(2013) Jun Zhang et al.   PLoS One

Inflammation and Adaptive Immunity in Parkinson's Disease

(2013) R. L. Mosley et al.   Cold Spring Harbor Perspectives in Medicine

IL-17 cytokines in immunity and inflammation

(2013) Wei Jin et al.   Emerging Microbes & Infections

Th17 Cells

(2012) Mohan S. Maddur et al.   AMERICAN JOURNAL OF PATHOLOGY

New insights of T cells in the pathogenesis of psoriasis

(2012) Yihua Cai et al.   Cellular & Molecular Immunology

Effect of short-term interferon-β treatment on cytokines in multiple sclerosis: Significant modulation of IL-17 and IL-23

(2012) Murat Kürtüncü et al.   CYTOKINE

Human Th17 subsets

(2012) Federica Sallusto et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rheumatoid arthritis: From autoimmunity to synovitis and joint destruction

(2012) Marie-Christophe Boissier et al.   JOURNAL OF AUTOIMMUNITY

Stimulation of Dopamine Receptor D5 Expressed on Dendritic Cells Potentiates Th17-Mediated Immunity

(2012) C. Prado et al.   JOURNAL OF IMMUNOLOGY

Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?

(2012) Marco Cosentino et al.   Journal of Neuroimmune Pharmacology

Evaluation of Th17-related cytokines and receptors in multiple sclerosis patients under interferon beta-1 therapy

(2012) Gunes Esendagli et al.   JOURNAL OF NEUROIMMUNOLOGY

Defining the human T helper 17 cell phenotype

(2012) Francesco Annunziato et al.   TRENDS IN IMMUNOLOGY

An update on vitamin D and human immunity

(2011) Martin Hewison   CLINICAL ENDOCRINOLOGY

The many faces of Th17 cells

(2011) Anneli Peters et al.   CURRENT OPINION IN IMMUNOLOGY

Effects of peripheral lymphocyte subpopulations and the clinical correlation with Parkinson's disease

(2011) Fumitoshi Niwa et al.   Geriatrics & Gerontology International

Dopamine up-regulates Th17 phenotype from individuals with generalized anxiety disorder

(2011) Thais B. Ferreira et al.   JOURNAL OF NEUROIMMUNOLOGY

Vitamin D regulation of immune function in the gut: Why do T cells have vitamin D receptors?

(2011) Jot Hui Ooi et al.   MOLECULAR ASPECTS OF MEDICINE

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF

(2011) Mohamed El-Behi et al.   NATURE IMMUNOLOGY

Th17 Cell, the New Player of Neuroinflammatory Process in Multiple Sclerosis

(2011) F. Jadidi-Niaragh et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

(2011) Kamran Ghoreschi et al.   TRENDS IN IMMUNOLOGY

Interleukin-17 and interleukin-23 are elevated in serum and cerebrospinal fluid of patients with ALS: a reflection of Th17 cells activation?

(2010) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer’s disease

(2010) Marina Saresella et al.   BRAIN BEHAVIOR AND IMMUNITY

IL-17 family member cytokines: Regulation and function in innate immunity

(2010) Joseph M. Reynolds et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Inflammation and Parkinson's disease pathogenesis

(2010) Serge Przedborski   MOVEMENT DISORDERS

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells

(2010) J. J. O'Shea et al.   SCIENCE

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

(2009) Hui Shen et al.   ARTHRITIS AND RHEUMATISM

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

The immunoregulatory role of dopamine: An update

(2009) Chandrani Sarkar et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammation in Parkinson’s Disease

(2009) Jae-Kyung Lee et al.   Journal of Neuroimmune Pharmacology

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Autoimmune disease and risk for Parkinson disease: A population-based case-control study

(2009) K. Rugbjerg et al.   NEUROLOGY

Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: A systematic review

(2009) L. Correia Guedes et al.   PARKINSONISM & RELATED DISORDERS

CD4 T-cell differentiation and inflammatory bowel disease

(2009) Lauren A. Zenewicz et al.   TRENDS IN MOLECULAR MEDICINE

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Multiple roles for CD4+T cells in anti-tumor immune responses

(2008) Richard Kennedy et al.   IMMUNOLOGICAL REVIEWS

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION

Psoriasis Vulgaris Lesions Contain Discrete Populations of Th1 and Th17 T Cells

(2008) Michelle A. Lowes et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY