期刊
CURRENT OPINION IN PHARMACOLOGY
卷 17, 期 -, 页码 12-16出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coph.2014.06.004
关键词
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资金
- AIRC
- MIUR
- Italian Ministry of Health [RF-2010-2314610]
CD4+ T cells can be classified from a functional point of view in different lineages, the most extensively studied being the Th1, Th2, and Th17. Recent evidence suggest that the acquisition of a certain phenotype is not irreversible, and lymphocytes can acquire features of different effector fates upon adequate stimuli. In particular, Th17 lymphocytes in inflammatory conditions can start to produce IFN-gamma or IL-4, shifting towards a Th17/Th1 or Th17/Th2 phenotype, respectively. Th17/Th1 and Th17/Th2 cells, seems to be more pathogenic than the unshifted cells. The possibility to interfere with this modulation of phenotype can be considered a possible target for developing novel therapeutic strategies in those inflammatory conditions in which the shifting of Th17 cells, particularly towards the Th1 phenotype, can occur.
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