Review
Pharmacology & Pharmacy
Laeza Alves Sampaio, Licia Tairiny Santos Pina, Mairim Russo Serafini, Debora dos Santos Tavares, Adriana Gibara Guimaraes
Summary: Carvacrol and thymol, natural compounds, exhibit antitumor and antiproliferative activities by acting through multiple signaling pathways. Carvacrol appears to be more potent than thymol in vitro, but further in vivo studies are needed to determine safe doses, toxic effects, and clarify exact mechanisms of action.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Lixuan Li, Xiaochun Chen, Keying Zhang, Gang Tian, Xuemei Ding, Shiping Bai, Qiufeng Zeng
Summary: This study evaluated the effect of supplementation with thymol and carvacrol eutectic (TCE) on broiler chickens. The results showed that TCE supplementation improved growth performance, intestinal morphology, nutrient absorption and transport capacities, as well as barrier function and inflammatory status.
Article
Food Science & Technology
Wu Wang, Tingting Li, Jing Chen, Yingwang Ye
Summary: This research investigates the antibacterial potential of plant essential oil components against Salmonella Enteritidis. Thymol, carvacrol, and cinnamaldehyde were found to have the best inhibitory effect on S. Enteritidis. Thymol and carvacrol not only maintained the sensory quality of chicken, but also reduced pH, moisture content, and TVB-N value.
Article
Food Science & Technology
Charlene Leneveu-Jenvrin, Aouatif Aboudia, Sophie Assemat, Fabienne Remize
Summary: The addition of thyme and Moroccan thyme essential oils inhibits fungal growth in pineapple juice, extending its shelf life. The low pH of the juice enhances the antifungal effect of the compounds. Despite the addition of thyme scent, the characteristic pineapple and sugary descriptors are maintained.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sandra T. Krause, Pan Liao, Christoph Crocoll, Benoit Boachon, Christiane Foerster, Franziska Leidecker, Natalie Wiese, Dongyan Zhao, Joshua C. Wood, C. Robin Buell, Jonathan Gershenzon, Natalia Dudareva, Joerg Degenhardt
Summary: Thymol and carvacrol are phenolic monoterpenes with antibacterial and anti-spasmolytic properties. Their biosynthesis involves cyclization and oxidation reactions, with specific enzymes playing key roles. The study provides new insights into the formation mechanism of these compounds.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Food Science & Technology
Cristina Fuentes, Samuel Verdu, Ana Fuentes, Maria Jose Ruiz, Jose Manuel Barat
Summary: The study evaluated the toxicity of four widely used essential oil components on nematodes and found that these compounds had a concentration-dependent effect on nematode survival at moderate to high concentrations, with reproduction being a more sensitive endpoint for toxicity evaluation. The findings suggest that these compounds can be toxic at lower doses than those required for their biological action.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Tareq M. Osaili, Fayeza Hasan, Dinesh Kumar Dhanasekaran, Reyad S. Obaid, Anas A. Al-Nabulsi, Mutamed Ayyash, Layal Karam, Ioannis N. Savvaidis, Richard Holley
Summary: The study evaluated the antimicrobial effect of active essential oil components on Listeria monocytogenes, Salmonella spp., and Escherichia coli O157:H7 in chicken tawook during storage. Results showed that the marinade significantly reduced L. monocytogenes and Salmonella spp. numbers at 10°C, while the addition of essential oils did not affect the pathogen populations.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Isis Caroline da Silva Cirino, Caroline Ferreira de Santana, Maria Jose Ribeiro Bezerra, Igor Vasconcelos Rocha, Ana Carolina de Oliveira Luz, Henrique Douglas Melo Coutinho, Regina Celia Bressan Queiroz de Figueiredo, Antonio Raposo, Linda Heejung Lho, Heesup Han, Tereza Cristina Leal-Balbino
Summary: This study evaluated the antibacterial activity of thymol and carvacrol against multidrug-resistant Acinetobacter baumannii. The results showed that thymol and carvacrol alone effectively inhibited the bacterial growth, and their combination exhibited synergistic or additive effects. Transcriptomic analysis revealed the regulation of stress response pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Katherine Miranda-Cadena, Cristina Marcos-Arias, Estibaliz Mateo, Jose Manuel Aguirre-Urizar, Guillermo Quindos, Elena Eraso
Summary: The study evaluated the effects of three phytocompounds on Candida planktonic and sessile cells, with cinnamaldehyde being the most active in inhibiting biofilm adhesion, while carvacrol and thymol significantly reduced both mature biofilm biomass and metabolic activity. These results highlight the potential of cinnamaldehyde, carvacrol, and thymol as promising alternatives for candidiasis treatment and emphasize the need for further research on their safety, toxicity, pharmacodynamics, and pharmacokinetics.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Agricultural Engineering
Fernanda Tomiotto-Pellissier, Bruna Taciane da Silva Bortoleti, Virginia Marcia Concato, Ana Flavia Marques Ganaza, Ana Carolina Quasne, Beatriz Ricci, Pedro Vinicius Dolce E Carvalho, Gustavo Henrique Della Colleta, Danielle Lazarin-Bidoia, Taylon Felipe Silva, Manoela Daiele Goncalves, Renata Katsuko Takayama Kobayashi, Gerson Nakazato, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: This study investigated the leishmanicidal and immunomodulatory effects of oregano essential oil (OEO) on experimental Leishmania amazonensis-model through in silico, in vitro, and in vivo approaches. The results demonstrated that OEO containing carvacrol, thymol, gamma-terpinene, p-cymene, and beta-caryophyllene as the main components showed potential as an oral and topical drug development for the treatment of L. amazonensis. OEO exhibited leishmanicidal activity by inducing a combination of autophagic, apoptotic, and necrotic events, and had immunomodulatory effects without triggering a pro-inflammatory response.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Maciej Walczak, Marta Michalska-Sionkowska, Daria Olkiewicz, Patrycja Tarnawska, Oliwia Warzynska
Summary: The study showed that thymol and carvacrol can effectively inhibit biofilm formation and enzyme activity of Staphylococcus aureus and Pseudomonas aeruginosa, with high antimicrobial properties demonstrated in both 3-day and 10-day experiments.
Review
Veterinary Sciences
Majid Gholami-Ahangaran, Asiye Ahmadi-Dastgerdi, Shahrzad Azizi, Asal Basiratpour, Maryam Zokaei, Masoud Derakhshan
Summary: This study discusses the role of thymol and carvacrol in poultry production, showing that these natural compounds have a wide range of biological activities, including promoting growth, improving feed utilization, and protecting the liver in chickens. Additionally, they can impact egg composition, quality, and chicken behavior.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Plant Sciences
Valiollah Mohammadi, Samaneh Talebi, Masoumeh Ahmadnasab, Hossein Mollahassanzadeh
Summary: Inducing polyploidy in Thymus vulgaris leads to larger vegetative and reproductive plant organs. The application of colchicine at a concentration of 0.3% on 4-leaf seedlings for 6 hours resulted in the highest survival rate and the highest number of tetraploid plants. Tetraploid plants exhibited significant morphological and physiological differences compared to diploid plants.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Panagiota G. V. Liggri, Katerina E. Tsitsanou, Evgenia C. V. Stamati, Francesca Saitta, Christina E. Drakou, Demetres D. Leonidas, Dimitrios Fessas, Spyros E. Zographos
Summary: Among proteins involved in insect olfactory perception, Odorant Binding Proteins (OBPs) are potential targets for discovering compounds to disrupt host-detection behavior. The crystal structures of AgamOBP5 in complex with natural repellents Carvacrol and Thymol, and MPD molecule are presented. Structural analysis revealed that both repellents occupy a binding site with two alternative conformations, and Carvacrol was found bound to a secondary site as well. Fluorescence competition and Calorimetry experiments confirmed the presence of two binding sites and the stabilization effect on AgamOBP5.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Jakubczyk, Slawomir Michalkiewicz, Agata Skorupa, Daria Slefarska
Summary: A simple, rapid, and sensitive method using differential pulse voltammetry (DPV) has been developed to determine the total content of thymol and carvacrol in herbal spices. The method showed a wide linear response range and low detection limits, with results in good agreement with standard chromatographic methods. This electrochemical procedure is the first of its kind for these compounds in these environmental and electrode materials.
Article
Agriculture, Dairy & Animal Science
M. Rodehutscord, O. Adeola, R. Angel, P. Bikker, E. Delezie, W. A. Dozier, M. Umar Faruk, M. Francesch, C. Kwakernaak, A. Narcy, C. M. Nyachoti, O. A. Olukosi, A. Preynat, B. Renouf, A. Saiz del Barrio, K. Schedle, W. Siegert, S. Steenfeldt, M. M. van Krimpen, S. M. Waititu, M. Witzig
Article
Genetics & Heredity
Marcel Hulst, Alfons Jansman, Ilonka Wijers, Arjan Hoekman, Stephanie Vastenhouw, Marinus van Krimpen, Mari Smits, Dirkjan Schokker
GENES AND NUTRITION
(2017)
Article
Agriculture, Dairy & Animal Science
M. Torki, D. Schokker, M. Duijster-Lensing, M. M. Van Krimpen
BRITISH POULTRY SCIENCE
(2018)
Article
Agriculture, Dairy & Animal Science
Luis A. Rubio
Article
Genetics & Heredity
Marcel Hulst, Rommie van der Weide, Arjan Hoekman, Marinus van Krimpen
GENES AND NUTRITION
(2019)
Review
Food Science & Technology
Isabel Aranda-Olmedo, Luis A. Rubio
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Food Science & Technology
Luis A. Rubio, Isabel Aranda-Olmedo, Mercedes Martin-Pedrosa
Article
Agriculture, Multidisciplinary
Luis A. Rubio, Isabel Aranda-Olmedo, Soraya Contreras, Tania Gongora, Gema Dominguez, Juan M. Peralta-Sanchez, Mercedes Martin-Pedrosa
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2020)
Article
Food Science & Technology
Raquel Ruiz, Raquel Olias, Alfonso Clemente, Luis A. Rubio
Article
Microbiology
Shui Ping Wang, Luis A. Rubio, Sylvia H. Duncan, Gillian E. Donachie, Grietje Holtrop, Galiana Lo, Freda M. Farquharson, Josef Wagner, Julian Parkhill, Petra Louis, Alan W. Walker, Harry J. Flint
Proceedings Paper
Agriculture, Dairy & Animal Science
Rick A. van Emous, Marinus M. van Krimpen
POULTRY FEATHERS AND SKIN: THE POULTRY INTEGUMENT IN HEALTH AND WELFARE
(2019)
Article
Food Science & Technology
N. Moussou, M. Ouazib, J. Wanasundara, F. Zaidi, L. A. Rubio
INTERNATIONAL FOOD RESEARCH JOURNAL
(2019)
Article
Veterinary Sciences
Laura Bona, Nienke van Staaveren, Bishwo Bandhu Pokharel, Marinus van Krimpen, Alexandra Harlander-Matauschek
FRONTIERS IN VETERINARY SCIENCE
(2018)
Article
Evolutionary Biology
Manuel Soler, Luis A. Rubio, Tomas Perez-Contreras, Juan Ontanilla, Liesbeth De Neve
BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
(2017)
Review
Agriculture, Dairy & Animal Science
C. P. A. van Wagenberg, Y. de Haas, H. Hogeveen, M. M. van Krimpen, M. P. M. Meuwissen, C. E. van Middelaar, T. B. Rodenburg
Article
Agriculture, Dairy & Animal Science
Telisson Ribeiro Goncalves, Jose Renaldo Vilar da Silva Filho, Gilmar Amaro Pereira, Tarcisio Martins Meira, Moema Kelly Nogueira de Sa, Glayciane Costa Gois, Crislane de Souza Silva, Fleming Sena Campos, Sandra Mari Yamamoto, Gherman Garcia Leal de Araujo
Summary: This study evaluated the effects of diets containing vitiviniculture waste on intake, digestibility, water balance, nitrogen balance, ingestive behavior, performance, and carcass traits of lambs. The results showed that feeding lambs with diets containing 216 g/kg cactus pear and 144 g/kg vitiviniculture waste resulted in higher intake and digestibility.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Q. Zhang, C. L. Walk, A. J. Cowieson, K. Stamatopoulos, J. L. Wu, J. O. B. Sorbara
Summary: This study evaluated the efficacy of a novel phytase in terms of phytate hydrolysis and the digestibility of phosphorus and calcium in broiler chickens fed low and high phytate diets. The results showed that the phytase effectively hydrolyzed phytate and increased digestible phosphorus and calcium. The response to dietary phytate varied in terms of age and the specific nutrient being evaluated.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
J. Song, D. M. Holanda, C. H. Heuer, C. M. Nyachoti
Summary: This study determined the energy contents of hybrid rye fed to growing pigs, and investigated the effects of particle size on energy values. Results showed that finely ground hybrid rye had higher digestible energy and metabolizable energy compared to coarsely ground hybrid rye, while net energy only showed a slight improvement.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Mohamed Salah Ayyat, Ahmed Mohamed Nabil Ayyat, Mohamed S. Abdel-Rahman, Adham A. Al-Sagheer
Summary: This study evaluated the impact of replacing fish meal with sugar beet and carrot leaf protein concentrate in Nile tilapia. The results showed that replacing 75% of fish meal with leaf protein concentrate had no adverse effects on growth and health, and it was more efficient in terms of economic benefits.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2024)