Machine Learning in Amyotrophic Lateral Sclerosis: Achievements, Pitfalls, and Future Directions

Data-Driven Based Approach to Aid Parkinson’s Disease Diagnosis

(2019) Nicolas Khoury et al.   SENSORS

Progress and new frontiers in biomarkers for amyotrophic lateral sclerosis

(2018) Martin R Turner   Biomarkers in Medicine

TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis

(2018) Vivek Majumder et al.   BMC Neurology

Connectivity-based characterisation of subcortical grey matter pathology in frontotemporal dementia and ALS: a multimodal neuroimaging study

(2018) Peter Bede et al.   Brain Imaging and Behavior

P48. Progression of cerebellar involvement in amyotrophic lateral sclerosis as seen by SUIT/ CAT12 voxel-based morphometry and D50 disease modelling

(2018) M. Batyrbekova et al.   CLINICAL NEUROPHYSIOLOGY

8. Predicting motor disorders from nerve excitability studies

(2018) T. Li et al.   CLINICAL NEUROPHYSIOLOGY

10. Phenotypic variability in motor neuron disease: Site of onset and patterns of disease spread

(2018) Thanuja Dharmadasa et al.   CLINICAL NEUROPHYSIOLOGY

The changing landscape of motor neuron disease imaging

(2018) Peter Bede et al.   CURRENT OPINION IN NEUROLOGY

Neuroimaging in amyotrophic lateral sclerosis: current and emerging uses

(2018) Federica Agosta et al.   Expert Review of Neurotherapeutics

CSF neurofilament proteins as diagnostic and prognostic biomarkers for amyotrophic lateral sclerosis

(2018) Daniela Rossi et al.   JOURNAL OF NEUROLOGY

Multimodal spinal cord MRI offers accurate diagnostic classification in ALS

(2018) Giorgia Querin et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

(2018) Anne E Visser et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Stage at which riluzole treatment prolongs survival in patients with amyotrophic lateral sclerosis: a retrospective analysis of data from a dose-ranging study

(2018) Ton Fang et al.   LANCET NEUROLOGY

Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model

(2018) Henk-Jan Westeneng et al.   LANCET NEUROLOGY

Motor unit number index and neurophysiological index as candidate biomarkers of presymptomatic motor neuron loss in amyotrophic lateral sclerosis

(2018) Marcio Luiz Escorcio-Bezerra et al.   MUSCLE & NERVE

Motor neuron disease in 2017: Progress towards therapy in motor neuron disease

(2018) Matthew C. Kiernan   Nature Reviews Neurology

Unraveling ALS due toSOD1mutation through the combination of brain and cervical cord MRI

(2018) Federica Agosta et al.   NEUROLOGY

Kinematic Features of Jaw and Lips Distinguish Symptomatic From Presymptomatic Stages of Bulbar Decline in Amyotrophic Lateral Sclerosis

(2018) Andrea Bandini et al.   JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH

Data-driven identification of endophenotypes of Alzheimer’s disease progression: implications for clinical trials and therapeutic interventions

(2018) Nophar Geifman et al.   Alzheimers Research & Therapy

Multicenter validation of [18F]-FDG PET and support-vector machine discriminant analysis in automatically classifying patients with amyotrophic lateral sclerosis versus controls

(2018) Ludovic D’hulst et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Deconstructing progression of amyotrophic lateral sclerosis in stages: a Markov modeling approach

(2018) Nimish J. Thakore et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Neuroimaging in amyotrophic lateral sclerosis: current and emerging uses

(2018) Federica Agosta et al.   Expert Review of Neurotherapeutics

Unraveling the Complexity of Amyotrophic Lateral Sclerosis Survival Prediction

(2018) Stephen R. Pfohl et al.   Frontiers in Neuroinformatics

The two-year progression of structural and functional cerebral MRI in amyotrophic lateral sclerosis

(2018) R.A.L. Menke et al.   NeuroImage-Clinical

Altered white matter microarchitecture in amyotrophic lateral sclerosis: A voxel-based meta-analysis of diffusion tensor imaging

(2018) Feifei Zhang et al.   NeuroImage-Clinical

A dynamic gradient boosting machine using genetic optimizer for practical breast cancer prognosis

(2018) Hongya Lu et al.   EXPERT SYSTEMS WITH APPLICATIONS

Epidemiology of amyotrophic lateral sclerosis in Southern Germany

(2017) Angela Rosenbohm et al.   JOURNAL OF NEUROLOGY

Dermatologist-level classification of skin cancer with deep neural networks

(2017) Andre Esteva et al.   NATURE

Memory-related white matter tract integrity in amyotrophic lateral sclerosis: an advanced neuroimaging and neuropsychological study

(2017) Foteini Christidi et al.   NEUROBIOLOGY OF AGING

Multi-View Ensemble Classification of Brain Connectivity Images for Neurodegeneration Type Discrimination

(2017) Michele Fratello et al.   NEUROINFORMATICS

A case-control study of hormonal exposures as etiologic factors for ALS in women

(2017) James P.K. Rooney et al.   NEUROLOGY

Predicting functional decline and survival in amyotrophic lateral sclerosis

(2017) Mei-Lyn Ong et al.   PLoS One

Individual treatment effect prediction for amyotrophic lateral sclerosis patients

(2017) Heidi Seibold et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Complete hazard ranking to analyze right-censored data: An ALS survival study

(2017) Zhengnan Huang et al.   PLoS Computational Biology

Longitudinal modeling to predict vital capacity in amyotrophic lateral sclerosis

(2017) Samad Jahandideh et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Longitudinal structural changes in ALS: a three time-point imaging study of white and gray matter degeneration

(2017) Peter Bede et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Prognostic value of clinical and electrodiagnostic parameters at time of diagnosis in patients with amyotrophic lateral sclerosis

(2017) Wendeline Reniers et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria

(2017) Michael J. Strong et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Deep learning predictions of survival based on MRI in amyotrophic lateral sclerosis

(2017) Hannelore K. van der Burgh et al.   NeuroImage-Clinical

Multimodal structural MRI in the diagnosis of motor neuron diseases

(2017) Pilar M. Ferraro et al.   NeuroImage-Clinical

Virtual brain biopsies in amyotrophic lateral sclerosis: Diagnostic classification based on in vivo pathological patterns

(2017) Peter Bede et al.   NeuroImage-Clinical

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

A Cross-sectional population-based investigation into behavioral change in amyotrophic lateral sclerosis: subphenotypes, staging, cognitive predictors, and survival

(2017) Tom Burke et al.   Annals of Clinical and Translational Neurology

Lower motor neuron involvement in ALS assessed by motor unit number index (MUNIX): Long-term changes and reproducibility

(2016) Davood Fathi et al.   CLINICAL NEUROPHYSIOLOGY

Creatine kinase enzyme level correlates positively with serum creatinine and lean body mass, and is a prognostic factor for survival in amyotrophic lateral sclerosis

(2016) M. K. Rafiq et al.   EUROPEAN JOURNAL OF NEUROLOGY

The segmental diffusivity profile of amyotrophic lateral sclerosis associated white matter degeneration

(2016) C. Schuster et al.   EUROPEAN JOURNAL OF NEUROLOGY

Amyotrophic lateral sclerosis: a comparison of two staging systems in a population-based study

(2016) D. Ferraro et al.   EUROPEAN JOURNAL OF NEUROLOGY

The corticospinal tract profile in amyotrophic lateral sclerosis

(2016) Alessia Sarica et al.   HUMAN BRAIN MAPPING

Decision forest: Twenty years of research

(2016) Lior Rokach   Information Fusion

A Structural Parametrization of the Brain Using Hidden Markov Models-Based Paths in Alzheimer’s Disease

(2016) Francisco J. Martinez-Murcia et al.   International Journal of Neural Systems

Semi-supervised learning of the electronic health record for phenotype stratification

(2016) Brett K. Beaulieu-Jones et al.   JOURNAL OF BIOMEDICAL INFORMATICS

A clinical tool for predicting survival in ALS

(2016) Jonathan A Knibb et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis

(2016) Hans-Peter Müller et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyotrophic lateral sclerosis: moving towards a new classification system

(2016) Ammar Al-Chalabi et al.   LANCET NEUROLOGY

Decoding ALS: from genes to mechanism

(2016) J. Paul Taylor et al.   NATURE

Associations between education and brain structure at age 73 years, adjusted for age 11 IQ

(2016) Simon R. Cox et al.   NEUROLOGY

Projected increase in amyotrophic lateral sclerosis from 2015 to 2040

(2016) Karissa C. Arthur et al.   Nature Communications

Identification and outcomes of clinical phenotypes in amyotrophic lateral sclerosis/motor neuron disease: Australian National Motor Neuron Disease observational cohort

(2016) Paul Talman et al.   BMJ Open

Identifying behavioural changes in ALS: Validation of the Beaumont Behavioural Inventory (BBI)

(2016) Marwa Elamin et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

The selective anatomical vulnerability of ALS: ‘disease-defining’ and ‘disease-defying’ brain regions

(2016) Peter Bede et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Predicting disease progression in amyotrophic lateral sclerosis

(2016) Albert A. Taylor et al.   Annals of Clinical and Translational Neurology

Development of an Automated MRI-Based Diagnostic Protocol for Amyotrophic Lateral Sclerosis Using Disease-Specific Pathognomonic Features: A Quantitative Disease-State Classification Study

(2016) Christina Schuster et al.   PLoS One

Protein Secondary Structure Prediction Using Deep Convolutional Neural Fields

(2016) Sheng Wang et al.   Scientific Reports

Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis

(2016) Geert Litjens et al.   Scientific Reports

Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways

(2015) Jacob I. Ayers et al.   ACTA NEUROPATHOLOGICA

Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD): Explanation and Elaboration

(2015) Karel G.M. Moons et al.   ANNALS OF INTERNAL MEDICINE

Evidence of hydrogen sulfide involvement in amyotrophic lateral sclerosis

(2015) Alessandro Davoli et al.   ANNALS OF NEUROLOGY

Predicting Early Bulbar Decline in Amyotrophic Lateral Sclerosis: A Speech Subsystem Approach

(2015) Panying Rong et al.   BEHAVIOURAL NEUROLOGY

Stratification of ALS patients’ survival: a population-based study

(2015) Benoît Marin et al.   JOURNAL OF NEUROLOGY

Predicting prognosis in amyotrophic lateral sclerosis: a simple algorithm

(2015) Marwa Elamin et al.   JOURNAL OF NEUROLOGY

Caregiver burden in amyotrophic lateral sclerosis: a cross-sectional investigation of predictors

(2015) Tom Burke et al.   JOURNAL OF NEUROLOGY

Time to generalisation as a predictor of prognosis in amyotrophic lateral sclerosis: Table 1

(2015) Rosanna Tortelli et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neurofilaments in the diagnosis of motoneuron diseases: a prospective study on 455 patients

(2015) Petra Steinacker et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Presymptomatic and longitudinal neuroimaging in neurodegeneration—from snapshots to motion picture: a systematic review

(2015) Christina Schuster et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Machine learning applications in genetics and genomics

(2015) Maxwell W. Libbrecht et al.   NATURE REVIEWS GENETICS

Factors Predicting Survival in ALS Patients - Data from a Population-Based Registry in Rhineland-Palatinate, Germany

(2015) Joachim Wolf et al.   NEUROEPIDEMIOLOGY

Basal ganglia pathology in ALS is associated with neuropsychological deficits

(2015) Judith Machts et al.   NEUROLOGY

Erratum to: One-class kernel subspace ensemble for medical image classification

(2015) Yungang Zhang et al.   EURASIP Journal on Advances in Signal Processing

Machine learning applications in cancer prognosis and prediction

(2015) Konstantina Kourou et al.   Computational and Structural Biotechnology Journal

Cerebrospinal fluid neurofilament light chain levels: marker of progression to generalized amyotrophic lateral sclerosis

(2014) R. Tortelli et al.   EUROPEAN JOURNAL OF NEUROLOGY

Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis

(2014) John Ravits   EXPERIMENTAL NEUROLOGY

Prognostic factors for the course of functional status of patients with ALS: a systematic review

(2014) Huub Creemers et al.   JOURNAL OF NEUROLOGY

Serum phosphorylated neurofilament-heavy chain levels in multiple sclerosis patients

(2014) M. M. Gresle et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Patterns of cerebral and cerebellar white matter degeneration in ALS: Figure 1

(2014) P Bede et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Use of clinical staging in amyotrophic lateral sclerosis for phase 3 clinical trials

(2014) Rubika Balendra et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression

(2014) Robert Küffner et al.   NATURE BIOTECHNOLOGY

The PRO-ACT database: Design, initial analyses, and predictive features

(2014) N. Atassi et al.   NEUROLOGY

A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS

(2014) Michael E. Bozik et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

RandomForest4Life: A Random Forest for predicting ALS disease progression

(2014) Torsten Hothorn et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

The El Escorial criteria: Strengths and weaknesses

(2014) Federica Agosta et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Estimating clinical stage of amyotrophic lateral sclerosis from the ALS Functional Rating Scale

(2014) Rubika Balendra et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Assessing Bias in Studies of Prognostic Factors

(2013) Jill A. Hayden et al.   ANNALS OF INTERNAL MEDICINE

The Utility of Independent Component Analysis and Machine Learning in the Identification of the Amyotrophic Lateral Sclerosis Diseased Brain

(2013) Robert C. Welsh et al.   Frontiers in Human Neuroscience

Artificial neural networks in medical diagnosis

(2013) Filippo Amato et al.   Journal of Applied Biomedicine

Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis

(2013) Adriano Chiò et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Controversies and priorities in amyotrophic lateral sclerosis

(2013) Martin R Turner et al.   LANCET NEUROLOGY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Global Epidemiology of Amyotrophic Lateral Sclerosis: A Systematic Review of the Published Literature

(2013) A. Chiò et al.   NEUROEPIDEMIOLOGY

Multiparametric MRI study of ALS stratified for the C9orf72 genotype

(2013) P. Bede et al.   NEUROLOGY

Basal ganglia involvement in amyotrophic lateral sclerosis

(2013) P. Bede et al.   NEUROLOGY

Cognitive changes predict functional decline in ALS: A population-based longitudinal study

(2013) M. Elamin et al.   NEUROLOGY

Amyotrophic lateral sclerosis disease progression model

(2013) Roberto Gomeni et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Sexual dimorphism in ALS: Exploring gender-specific neuroimaging signatures

(2013) Peter Bede et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

The involvement of the cerebellum in amyotrophic lateral sclerosis

(2013) Tino Prell et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

A proposed staging system for amyotrophic lateral sclerosis

(2012) J. C. Roche et al.   BRAIN

An efficient diagnosis system for detection of Parkinson’s disease using fuzzy k-nearest neighbor approach

(2012) Hui-Ling Chen et al.   EXPERT SYSTEMS WITH APPLICATIONS

Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality

(2012) P. Bede et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study

(2012) Susan Byrne et al.   LANCET NEUROLOGY

Machine learning algorithms to classify spinal muscular atrophy subtypes

(2012) T. Srivastava et al.   NEUROLOGY

Factors affecting the diagnostic delay in amyotrophic lateral sclerosis

(2011) Eleonora Cellura et al.   CLINICAL NEUROLOGY AND NEUROSURGERY

Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients

(2011) Per Zetterström et al.   JOURNAL OF NEUROCHEMISTRY

The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study

(2011) Julie Phukan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Towards a neuroimaging biomarker for amyotrophic lateral sclerosis

(2011) Martin R Turner et al.   LANCET NEUROLOGY

Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data

(2011) Sarah J Tabrizi et al.   LANCET NEUROLOGY

ALS clinical trials: Do enrolled patients accurately represent the ALS population?

(2011) A. Chio et al.   NEUROLOGY

Executive dysfunction is a negative prognostic indicator in patients with ALS without dementia

(2011) M. Elamin et al.   NEUROLOGY

Predicting survival in frontotemporal dementia with motor neuron disease

(2011) E. A. Coon et al.   NEUROLOGY

The Parkinson Progression Marker Initiative (PPMI)

(2011) Kenneth Marek et al.   PROGRESS IN NEUROBIOLOGY

Assessment of White Matter Tract Damage in Patients with Amyotrophic Lateral Sclerosis: A Diffusion Tensor MR Imaging Tractography Study: Fig 1.

(2010) F. Agosta et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Gaussian mixtures on tensor fields for segmentation: Applications to medical imaging

(2010) Rodrigo de Luis-García et al.   COMPUTERIZED MEDICAL IMAGING AND GRAPHICS

Galectin-3 Is a Candidate Biomarker for Amyotrophic Lateral Sclerosis: Discovery by a Proteomics Approach

(2010) Jian-Ying Zhou et al.   JOURNAL OF PROTEOME RESEARCH

Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis

(2010) N. Filippini et al.   NEUROLOGY

Identifying and Avoiding Bias in Research

(2010) Christopher J. Pannucci et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis

(2009) Michael J. Strong et al.   Amyotrophic Lateral Sclerosis

Prognostic factors in ALS: A critical review

(2009) Adriano Chiò et al.   Amyotrophic Lateral Sclerosis

Survival Profiles of Patients With Frontotemporal Dementia and Motor Neuron Disease

(2009) William T. Hu et al.   ARCHIVES OF NEUROLOGY

Epidemiology of ALS in Italy: A 10-year prospective population-based study

(2009) A. Chio et al.   NEUROLOGY

Clinical features that distinguish PLS, upper motor neuron-dominant ALS, and typical ALS

(2009) P. H. Gordon et al.   NEUROLOGY

Electrodiagnostic criteria for diagnosis of ALS

(2008) Mamede de Carvalho et al.   CLINICAL NEUROPHYSIOLOGY

An all-Ireland epidemiological study of MND, 2004-2005

(2008) C. Donaghy et al.   EUROPEAN JOURNAL OF NEUROLOGY

Biomarkers in amyotrophic lateral sclerosis

(2008) Martin R Turner et al.   LANCET NEUROLOGY

AUC: a misleading measure of the performance of predictive distribution models

(2007) Jorge M. Lobo et al.   GLOBAL ECOLOGY AND BIOGEOGRAPHY

An axiomatic approach to intrinsic dimension of a dataset

(2007) Vladimir Pestov   NEURAL NETWORKS